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    RGS7 regulator of G protein signaling 7 [ Homo sapiens (human) ]

    Gene ID: 6000, updated on 28-Oct-2024

    Summary

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    Official Symbol
    RGS7provided by HGNC
    Official Full Name
    regulator of G protein signaling 7provided by HGNC
    Primary source
    HGNC:HGNC:10003
    See related
    Ensembl:ENSG00000182901 MIM:602517; AllianceGenome:HGNC:10003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in G protein-coupled receptor signaling pathway; negative regulation of G protein-coupled receptor signaling pathway; and positive regulation of GTPase activity. Located in cytosol. Is active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in brain (RPKM 5.9), adrenal (RPKM 1.5) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS7 in Genome Data Viewer
    Location:
    1q43; 1q23.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (240774742..241357230, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (240186136..240768709, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (240938042..241520530, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506929 Neighboring gene THAP domain containing 12 pseudogene 8 Neighboring gene uncharacterized LOC124904602 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241051410-241051937 Neighboring gene riboflavin kinase pseudogene 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6389 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:241099640-241100839 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 42 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241133415-241133985 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_6394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241175575-241176086 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241208875-241209433 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:241208316-241208874 Neighboring gene ribosomal protein lateral stalk subunit P1 pseudogene 2 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241229736-241230326 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:241252482-241252653 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:241305709-241306361 Neighboring gene microRNA 3123 Neighboring gene Sharpr-MPRA regulatory region 3307 Neighboring gene MPRA-validated peak795 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2006 Neighboring gene uncharacterized LOC124904601 Neighboring gene ribosomal protein L36 pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr1:241581573-241582074 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:241602586-241603173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2007 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:241682833-241683429 Neighboring gene fumarate hydratase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway. Zhu Y, et al. Autoimmunity, 2023 Dec. PMID 36999276
    2. Association analysis of Rgs7 variants with panic disorder. Hohoff C, et al. J Neural Transm (Vienna), 2009 Nov. PMID 18762858
    3. Palmitoylation and plasma membrane targeting of RGS7 are promoted by alpha o. Takida S, et al. Mol Pharmacol, 2005 Jan. PMID 15496508
    4. Nuclear localization of G protein beta 5 and regulator of G protein signaling 7 in neurons and brain. Zhang JH, et al. J Biol Chem, 2001 Mar 30. PMID 11152459
    5. New single nucleotide polymorphisms associated with differences in platelets reactivity in patients with type 2 diabetes treated with acetylsalicylic acid: genome-wide association approach and pooled DNA strategy. Postula M, et al. J Thromb Thrombolysis, 2013 Jul. PMID 23054467

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.
      Title: RGS7 balances acetylation/de-acetylation of p65 to control chemotherapy-dependent cardiac inflammation.
    2. RGS7 silence protects palmitic acid-induced pancreatic beta-cell injury by inactivating the chemokine signaling pathway.
      Title: RGS7 silence protects palmitic acid-induced pancreatic β-cell injury by inactivating the chemokine signaling pathway.
    3. A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.
      Title: A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.
    4. Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gbeta5 signaling complex.
      Title: Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex.
    5. Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gbeta5.
      Title: Structure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
    6. Data mapped differences in deuterium exchange between the regulator of G protein signaling 7 (RGS7)-Gbeta5 protein(Gbeta5)-RGS7 family binding protein (R7BP) trimer and the RGS7-Gbeta5 dimer.
      Title: Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.
    7. Results found that RGS7 was mutated in 11% of melanomas with three recurrent mutations (p.R44C, p.E383K and p.R416Q). p.R44C was shown to destabilize the protein due to the loss of an H-bond and salt bridge. RGS7 p.R44C has weaker catalytic activity for its substrate Galphao, thus providing a dual mechanism for its loss of function resulting in increase anchorage-independent growth, migration and invasion of melanoma c...
      Title: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.
    8. Data (including data from studies using transgenic mice) suggest that R7BP-RGS7 heterotrimers interact with Galpha13 to augment signaling pathways in neurons that regulate neurite morphogenesis. (R7BP = RGS7 family binding protein; RGS7 = regulator of G-protein signaling 7 protein; Galpha13 = GTP-binding protein alpha subunit 13)
      Title: Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα(13).
    9. R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.
      Title: Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.
    10. Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval
      Title: Fine mapping of the uterine leiomyoma locus on 1q43 close to a lncRNA in the RGS7-FH interval.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein beta-subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 7
    Names
    regulator of G-protein signaling RGS7
    regulator of G-protein signalling 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282773.2 → NP_001269702.1  regulator of G-protein signaling 7 isoform 2

      See identical proteins and their annotated locations for NP_001269702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three alternate exons and contains another alternate exon compared to variant 1. The resulting isoform (2) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF493930, AL365184, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
      Consensus CDS
      CCDS60457.1
      UniProtKB/TrEMBL
      A0A8I5KR27
      Related
      ENSP00000341242.2, ENST00000348120.6
      Conserved Domains (4) summary
      smart00224
      Location:203 → 263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273 → 393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 76
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74 → 161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    2. NM_001282775.2 → NP_001269704.1  regulator of G-protein signaling 7 isoform 3

      See identical proteins and their annotated locations for NP_001269704.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon and contains another alternate exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF493931, AW872845, BC022009, BI547250, DA085997, DA605226, R43370
      Consensus CDS
      CCDS60459.1
      UniProtKB/TrEMBL
      A0A8I5KRS1
      Related
      ENSP00000355521.1, ENST00000366563.5
      Conserved Domains (4) summary
      smart00224
      Location:256 → 316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326 → 446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    3. NM_001282778.2 → NP_001269707.1  regulator of G-protein signaling 7 isoform 4

      See identical proteins and their annotated locations for NP_001269707.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AW872845, AY587875, BC022009, BI547250, DA085997, DA605226, R43370
      Consensus CDS
      CCDS60458.1
      UniProtKB/TrEMBL
      A0A8I5KY39
      Related
      ENSP00000355522.1, ENST00000366564.5
      Conserved Domains (4) summary
      smart00224
      Location:256 → 316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326 → 446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    4. NM_001350113.2 → NP_001337042.1  regulator of G-protein signaling 7 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
      Source sequence(s)
      AF493931, AL359764, AW872845, BC022009, DA085997, DA605226, R43370
      Consensus CDS
      CCDS91177.1
      UniProtKB/TrEMBL
      A0A8I5KRS1, B7Z257
      Conserved Domains (4) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:87 → 188
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    5. NM_001350114.2 → NP_001337043.1  regulator of G-protein signaling 7 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and longer 3' UTR. The resulting isoform (5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1. Variants 5 and 6 encode the same protein (isoform 5).
      Source sequence(s)
      AF493931, AL592076, AW872845, BC022009, DA085997, DA605226, R43370
      Consensus CDS
      CCDS91177.1
      UniProtKB/TrEMBL
      A0A8I5KRS1, B7Z257
      Related
      ENSP00000510372.1, ENST00000685936.1
      Conserved Domains (4) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:87 → 188
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    6. NM_001350115.2 → NP_001337044.1  regulator of G-protein signaling 7 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate exon in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
      Source sequence(s)
      AF493931, AL359764, AW872845, BC022009, DA085997, DA605226, R43370
      Consensus CDS
      CCDS91176.1
      UniProtKB/TrEMBL
      A0A8I5KXW5, A0A8I5KY39
      Related
      ENSP00000509046.1, ENST00000692410.1
      Conserved Domains (3) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    7. NM_001350116.1 → NP_001337045.1  regulator of G-protein signaling 7 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in its 5' UTR, resulting in use of a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (6) has a shorter N-terminus and lacks an internal segment compared to isoform 1. Variants 7 and 8 encode the same protein (isoform 6).
      Source sequence(s)
      AF493931, AL592076, AW872845, BC022009, DA085997, DA605226, R43370
      Consensus CDS
      CCDS91176.1
      UniProtKB/TrEMBL
      A0A8I5KXW5, A0A8I5KY39
      Related
      ENST00000690236.1
      Conserved Domains (3) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    8. NM_001364886.1 → NP_001351815.1  regulator of G-protein signaling 7 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) encodes the longest isoform (7).
      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Consensus CDS
      CCDS91181.1
      UniProtKB/Swiss-Prot
      P49802, Q5T3H4, Q8TD66, Q8TD67, Q8WW09, Q9UNU7, Q9Y6B9
      UniProtKB/TrEMBL
      A0A8I5KRS1
      Related
      ENSP00000404399.2, ENST00000440928.6
      Conserved Domains (4) summary
      smart00224
      Location:256 → 316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326 → 446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    9. NM_001374806.1 → NP_001361735.1  regulator of G-protein signaling 7 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      UniProtKB/TrEMBL
      A0A8I5KRS1
      Conserved Domains (4) summary
      smart00224
      Location:239 → 299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309 → 429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 99
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96 → 197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    10. NM_001374807.1 → NP_001361736.1  regulator of G-protein signaling 7 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Consensus CDS
      CCDS91178.1
      UniProtKB/TrEMBL
      A0A8I5KY39, A0A8I5KZ50
      Related
      ENSP00000510735.1, ENST00000690019.1
      Conserved Domains (4) summary
      smart00224
      Location:239 → 299
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:309 → 429
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 99
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:96 → 197
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    11. NM_001374808.1 → NP_001361737.1  regulator of G-protein signaling 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Consensus CDS
      CCDS91177.1
      UniProtKB/TrEMBL
      A0A8I5KRS1, B7Z257
      Conserved Domains (4) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:87 → 188
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    12. NM_001374809.1 → NP_001361738.1  regulator of G-protein signaling 7 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Conserved Domains (3) summary
      smart00224
      Location:163 → 223
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:233 → 353
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      pfam18148
      Location:71 → 121
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    13. NM_001374810.1 → NP_001361739.1  regulator of G-protein signaling 7 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      UniProtKB/TrEMBL
      Q5T3H5
      Conserved Domains (3) summary
      smart00224
      Location:163 → 223
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:233 → 353
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      pfam18148
      Location:71 → 121
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    14. NM_001374811.1 → NP_001361740.1  regulator of G-protein signaling 7 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      UniProtKB/TrEMBL
      A0A8I5KY39
      Conserved Domains (4) summary
      smart00224
      Location:203 → 263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273 → 393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 76
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74 → 161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    15. NM_001374812.1 → NP_001361741.1  regulator of G-protein signaling 7 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      UniProtKB/TrEMBL
      A0A8I5KZ23
      Conserved Domains (4) summary
      smart00224
      Location:231 → 291
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:301 → 421
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 203
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    16. NM_001374813.1 → NP_001361742.1  regulator of G-protein signaling 7 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Conserved Domains (2) summary
      smart00224
      Location:85 → 145
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:155 → 275
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

    17. NM_001374814.1 → NP_001361743.1  regulator of G-protein signaling 7 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Consensus CDS
      CCDS91179.1
      UniProtKB/TrEMBL
      A0A8I5KR27, A0A8I5QJU0
      Related
      ENSP00000510458.1, ENST00000689115.1
      Conserved Domains (4) summary
      smart00224
      Location:203 → 263
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:273 → 393
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 76
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:74 → 161
      RGS_DHEX; Regulator of G-protein signalling DHEX domain

    18. NM_001374815.1 → NP_001361744.1  regulator of G-protein signaling 7 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      Consensus CDS
      CCDS91180.1
      UniProtKB/TrEMBL
      A0A8I5KRS1, A0A8I5KUA7
      Related
      ENSP00000508919.1, ENST00000691989.1
      Conserved Domains (4) summary
      cd08738
      Location:289 → 409
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      pfam00631
      Location:256 → 282
      G-gamma; GGL domain

    19. NM_001374816.1 → NP_001361745.1  regulator of G-protein signaling 7 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL359764, AL365184, AL512307, AL590682
      UniProtKB/TrEMBL
      A0A8I5KY39
      Conserved Domains (4) summary
      cd08738
      Location:289 → 409
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam18148
      Location:113 → 214
      RGS_DHEX; Regulator of G-protein signalling DHEX domain
      cl00069
      Location:256 → 282
      GGL; G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors

    20. NM_002924.6 → NP_002915.3  regulator of G-protein signaling 7 isoform 1

      See identical proteins and their annotated locations for NP_002915.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL365184, AW872845, BC022009, BI547250, DA605226, R43370
      Consensus CDS
      CCDS31071.1
      UniProtKB/TrEMBL
      A0A8I5KY39
      Related
      ENSP00000355523.1, ENST00000366565.5
      Conserved Domains (3) summary
      smart00224
      Location:256 → 316
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:326 → 446
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:29 → 116
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      240774742..241357230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426980.1 → XP_047282936.1  regulator of G-protein signaling 7 isoform X1

    2. XM_017002009.2 → XP_016857498.1  regulator of G-protein signaling 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KXW5, A0A8I5KY39
      Conserved Domains (3) summary
      smart00224
      Location:230 → 290
      GGL; G protein gamma subunit-like motifs
      cd08738
      Location:300 → 420
      RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein
      cd04450
      Location:3 → 90
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      240186136..240768709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338041.1 → XP_054194016.1  regulator of G-protein signaling 7 isoform X3

    2. XM_054338043.1 → XP_054194018.1  regulator of G-protein signaling 7 isoform X3

    3. XM_054338044.1 → XP_054194019.1  regulator of G-protein signaling 7 isoform X1

    4. XM_054338042.1 → XP_054194017.1  regulator of G-protein signaling 7 isoform X3

    5. XM_054338045.1 → XP_054194020.1  regulator of G-protein signaling 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KXW5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49802.3 GenPept UniProtKB/Swiss-Prot:P49802

    Gene LinkOut

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