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    NOP14 NOP14 nucleolar protein [ Homo sapiens (human) ]

    Gene ID: 8602, updated on 3-Nov-2024

    Summary

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    Official Symbol
    NOP14provided by HGNC
    Official Full Name
    NOP14 nucleolar proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16821
    See related
    Ensembl:ENSG00000087269 MIM:611526; AllianceGenome:HGNC:16821
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UTP2; NOL14; C4orf9; RES425; RES4-25
    Summary
    This gene encodes a protein that plays a role in pre-18s rRNA processing and small ribosomal subunit assembly. The encoded protein may be involved in the regulation of pancreatic cancer cell proliferation and migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in lymph node (RPKM 10.9), appendix (RPKM 9.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NOP14 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (2937936..2963406, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (2936399..2962082, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (2939663..2965133, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15189 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15191 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21197 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2863877-2864589 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:2864590-2865301 Neighboring gene adducin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876343-2876870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2876871-2877396 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21198 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2923771-2924668 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2924669-2925564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2925565-2926460 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:2927877-2928392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2935265-2936132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15194 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:2937390-2938589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21204 Neighboring gene NOP14 antisense RNA 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:2948362-2949561 Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21205 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:2964791-2965324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:2965325-2965858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15196 Neighboring gene G protein-coupled receptor kinase 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3011160-3012359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21206 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3022951-3023451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21212 Neighboring gene RNA, U6 small nuclear 204, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exon trapping and sequence-based methods of gene finding in transcript mapping of human 4p16.3. Pribill I, et al. Somat Cell Mol Genet, 1997 Nov. PMID 9661704
    2. NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity. Yan X, et al. J Biol Chem, 2024 Mar. PMID 38272224, Free PMC Article
    3. NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway. Zhu X, et al. Eur J Histochem, 2021 Jul 2. PMID 34218653, Free PMC Article
    4. Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer. Lu C, et al. BMC Gastroenterol, 2022 Apr 26. PMID 35473611, Free PMC Article
    5. NOP14 promotes proliferation and metastasis of pancreatic cancer cells. Zhou B, et al. Cancer Lett, 2012 Sep 28. PMID 22425761

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
      Title: NOP14-mediated ribosome biogenesis is required for mTORC2 activation and predicts rapamycin sensitivity.
    2. Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
      Title: Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.
    3. NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3beta/beta-catenin signaling pathway.
      Title: NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway.
    4. CCND1, DNMT3B and NOP14 were identified as direct targets of miR-502-5p.
      Title: CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
    5. we identified an identical homozygous NOP14 variant as a possible contributing factor for RPL in two Iranian families.
      Title: A homozygous NOP14 variant is likely to cause recurrent pregnancy loss.
    6. Targeting NOP14 allows for effective suppression of tumor invasion in a mutp53-dependent manner, implicating NOP14 inhibition as a potential approach for attenuating metastasis in p53-mutant tumors
      Title: Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14.
    7. NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/beta-catenin pathway.
      Title: NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway.
    8. our study provides new evidence for NOP14 in regulating PC cell proliferation and migration, and may provide new insights for clinical diagnosis and therapy.
      Title: NOP14 promotes proliferation and metastasis of pancreatic cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snoRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Noc4p-Nop14p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc4p-Nop14p complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar protein 14
    Names
    NOP14 nucleolar protein homolog
    probable nucleolar complex protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291978.2 → NP_001278907.1  nucleolar protein 14 isoform 1

      See identical proteins and their annotated locations for NP_001278907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK025692, AK292939
      Consensus CDS
      CCDS33945.1
      UniProtKB/Swiss-Prot
      D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6
      UniProtKB/TrEMBL
      A8KA74
      Related
      ENSP00000405068.2, ENST00000416614.7
      Conserved Domains (2) summary
      pfam04147
      Location:20 → 846
      Nop14; Nop14-like family
      cl03951
      Location:202 → 321
      CDC37_N; Cdc37 N terminal kinase binding

    2. NM_001291979.2 → NP_001278908.1  nucleolar protein 14 isoform 2

      See identical proteins and their annotated locations for NP_001278908.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 3' coding region and differs in the 3' UTR, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK025692, AK292939, BC026035
      Consensus CDS
      CCDS77893.1
      UniProtKB/TrEMBL
      E9PFK5
      Related
      ENSP00000381146.4, ENST00000398071.4
      Conserved Domains (2) summary
      pfam04147
      Location:20 → 776
      Nop14; Nop14-like family
      cl03951
      Location:202 → 321
      CDC37_N; Cdc37 N terminal kinase binding

    3. NM_003703.3 → NP_003694.1  nucleolar protein 14 isoform 1

      See identical proteins and their annotated locations for NP_003694.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AF040965, AK025692, AK292939
      Consensus CDS
      CCDS33945.1
      UniProtKB/Swiss-Prot
      D3DVR6, P78316, Q7LGI5, Q7Z6K0, Q8TBR6
      UniProtKB/TrEMBL
      A8KA74
      Related
      ENSP00000315674.6, ENST00000314262.10
      Conserved Domains (2) summary
      pfam04147
      Location:20 → 846
      Nop14; Nop14-like family
      cl03951
      Location:202 → 321
      CDC37_N; Cdc37 N terminal kinase binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      2937936..2963406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416338.1 → XP_047272294.1  nucleolar protein 14 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      2936399..2962082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351138.1 → XP_054207113.1  nucleolar protein 14 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78316.3 GenPept UniProtKB/Swiss-Prot:P78316

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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