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    CEND1 cell cycle exit and neuronal differentiation 1 [ Homo sapiens (human) ]

    Gene ID: 51286, updated on 28-Oct-2024

    Summary

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    Official Symbol
    CEND1provided by HGNC
    Official Full Name
    cell cycle exit and neuronal differentiation 1provided by HGNC
    Primary source
    HGNC:HGNC:24153
    See related
    Ensembl:ENSG00000184524 MIM:608213; AllianceGenome:HGNC:24153
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BM88
    Summary
    The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 37.5) and adrenal (RPKM 2.6) See more
    Orthologs
    mouse all
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    Genomic context

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    See CEND1 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (787115..790090, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (838549..841523, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (787115..790090, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3026 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3027 Neighboring gene uncharacterized LOC124900301 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3028 Neighboring gene GATD1 divergent transcript Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:783107-783794 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:783795-784482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3029 Neighboring gene solute carrier family 25 member 22 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:794229-794747 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:795266-795784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:796302-796820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4279 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4281 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:797857-798373 Neighboring gene proapoptotic nucleolar protein 1 Neighboring gene p53-induced death domain protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:804161-804858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4284 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students. Hou B, et al. J Affect Disord, 2021 Jan 1. PMID 33027701
    2. CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults. Park J, et al. Exp Gerontol, 2022 Apr. PMID 35045349
    3. Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons. Aravantinou-Fatorou K, et al. Int J Dev Biol, 2022. PMID 34549796
    4. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. Katsimpardi L, et al. Stem Cells, 2008 Jul. PMID 18499894
    5. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. Gaitanou M, et al. Biochem J, 2001 May 1. PMID 11311134, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
      Title: Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons.
    2. CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
      Title: CEND1 and miR885 methylation changes associated with successful cognitive aging in community-dwelling older adults.
    3. Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
      Title: Interaction of CEND1 gene and life events in susceptibility to depressive symptoms in Chinese Han college students.
    4. BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels
      Title: BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ90066, MGC34326

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cerebellar Purkinje cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cerebellar granular layer maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cerebellar granule cell precursor proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in radial glia guided migration of cerebellar granule cell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell cycle exit and neuronal differentiation protein 1
    Names
    BM88 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016564.4 → NP_057648.2  cell cycle exit and neuronal differentiation protein 1

      See identical proteins and their annotated locations for NP_057648.2

      Status: REVIEWED

      Source sequence(s)
      AP006621, DA066200
      Consensus CDS
      CCDS7714.1
      UniProtKB/Swiss-Prot
      Q8N111, Q9NYM6
      UniProtKB/TrEMBL
      B2R7I3
      Related
      ENSP00000328336.4, ENST00000330106.5
      Conserved Domains (1) summary
      pfam15677
      Location:1 → 149
      CEND1; Cell cycle exit and neuronal differentiation protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      787115..790090 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      838549..841523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N111.1 GenPept UniProtKB/Swiss-Prot:Q8N111

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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