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    ACTR10 actin related protein 10 [ Homo sapiens (human) ]

    Gene ID: 55860, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ACTR10provided by HGNC
    Official Full Name
    actin related protein 10provided by HGNC
    Primary source
    HGNC:HGNC:17372
    See related
    Ensembl:ENSG00000131966 MIM:619731; AllianceGenome:HGNC:17372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Arp10; Arp11; ACTR11; HARP11
    Summary
    Predicted to be involved in retrograde axonal transport of mitochondrion. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cytosol; extracellular region; and secretory granule. Predicted to be part of dynactin complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 22.5), adrenal (RPKM 21.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ACTR10 in Genome Data Viewer
    Location:
    14q23.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (58200149..58235636)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (52407087..52442570)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (58666867..58702354)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5794 Neighboring gene Sharpr-MPRA regulatory region 2203 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8440 Neighboring gene RNA, 7SL, cytoplasmic 598, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5797 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8445 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:58711573-58712470 Neighboring gene tRNA-Lys (anticodon CTT) 1-1 Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene PSMA3 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interactions between the evolutionarily conserved, actin-related protein, Arp11, actin, and Arp1. Eckley DM, et al. Mol Biol Cell, 2003 Jul. PMID 12857853, Free PMC Article
    2. Monitoring protein-protein interactions between the mammalian integral membrane transporters and PDZ-interacting partners using a modified split-ubiquitin membrane yeast two-hybrid system. Gisler SM, et al. Mol Cell Proteomics, 2008 Jul. PMID 18407958, Free PMC Article
    3. The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. Bachmann-Gagescu R, et al. PLoS Genet, 2015 Oct. PMID 26485645, Free PMC Article
    4. Insights into the ubiquitin-proteasome system of human embryonic stem cells. Saez I, et al. Sci Rep, 2018 Mar 6. PMID 29511261, Free PMC Article
    5. Mapping the Genetic Landscape of Human Cells. Horlbeck MA, et al. Cell, 2018 Aug 9. PMID 30033366, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retrograde axonal transport of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    actin-related protein 10
    Names
    actin related protein 10 homolog
    actin-related protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018477.3 → NP_060947.1  actin-related protein 10

      See identical proteins and their annotated locations for NP_060947.1

      Status: VALIDATED

      Source sequence(s)
      AF220190, AL132989, CB135721
      Consensus CDS
      CCDS32090.1
      UniProtKB/Swiss-Prot
      Q9H9Y5, Q9NWY2, Q9NZ32
      UniProtKB/TrEMBL
      B2RDG9, Q53H79
      Related
      ENSP00000254286.4, ENST00000254286.9
      Conserved Domains (1) summary
      cl17037
      Location:14 → 388
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      58200149..58235636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536960.2 → XP_011535262.1  actin-related protein 10 isoform X1

      UniProtKB/TrEMBL
      B2RDG9, Q53H79
      Conserved Domains (2) summary
      pfam00022
      Location:14 → 395
      Actin; Actin
      cl17037
      Location:12 → 389
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    2. XM_011536961.2 → XP_011535263.1  actin-related protein 10 isoform X2

      UniProtKB/TrEMBL
      Q53H79
      Conserved Domains (2) summary
      pfam00022
      Location:14 → 376
      Actin; Actin
      cl17037
      Location:12 → 370
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. XM_047431587.1 → XP_047287543.1  actin-related protein 10 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      52407087..52442570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376393.1 → XP_054232368.1  actin-related protein 10 isoform X1

    2. XM_054376394.1 → XP_054232369.1  actin-related protein 10 isoform X2

    3. XM_054376395.1 → XP_054232370.1  actin-related protein 10 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZ32.1 GenPept UniProtKB/Swiss-Prot:Q9NZ32

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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