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    PBY1 putative tubulin tyrosine ligase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852391, updated on 18-Sep-2024

    Summary

    Official Symbol
    PBY1
    Official Full Name
    putative tubulin tyrosine ligase
    Primary source
    SGD:S000000298
    Locus tag
    YBR094W
    See related
    AllianceGenome:SGD:S000000298; FungiDB:YBR094W; VEuPathDB:YBR094W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP binding activity; hydrolase activity; and tubulin-tyrosine ligase activity. Predicted to be involved in cellular protein modification process. Located in P-body. Orthologous to human TTL (tubulin tyrosine ligase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See PBY1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (432036..434297)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene acid phosphatase PHO3 Neighboring gene acid phosphatase PHO5 Neighboring gene Rxt2p Neighboring gene uncharacterized protein

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    enables tubulin-tyrosine ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    putative tubulin tyrosine ligase
    NP_009652.2
    • Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      432036..434297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178442.2NP_009652.2  TPA: putative tubulin tyrosine ligase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009652.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ95, P38254
      UniProtKB/TrEMBL
      B3LN57, C7GUJ4, D3UEI9, G2W9A1, N1P9F7
      Conserved Domains (2) summary
      TIGR00087
      Location:1311
      surE; 5'/3'-nucleotidase SurE
      pfam03133
      Location:389732
      TTL; Tubulin-tyrosine ligase family