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    GNA13 G protein subunit alpha 13 [ Homo sapiens (human) ]

    Gene ID: 10672, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GNA13provided by HGNC
    Official Full Name
    G protein subunit alpha 13provided by HGNC
    Primary source
    HGNC:HGNC:4381
    See related
    Ensembl:ENSG00000120063 MIM:604406; AllianceGenome:HGNC:4381
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G13; HG1N
    Summary
    Enables G protein activity. Involved in G protein-coupled receptor signaling pathway. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 46.2), lymph node (RPKM 22.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GNA13 in Genome Data Viewer
    Location:
    17q24.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (65009289..65056740, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (65879260..65926708, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (63005407..63052858, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:62971753-62972623 Neighboring gene AMZ2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12605 Neighboring gene uncharacterized LOC124904044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:63023805-63024744 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:63024745-63025684 Neighboring gene NANOG hESC enhancer GRCh37_chr17:63043783-63044416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8859 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:63059883-63060849 Neighboring gene uncharacterized LOC105371864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8860 Neighboring gene uncharacterized LOC100507002

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Endothelin-B receptors activate Galpha13. Kitamura K, et al. Am J Physiol, 1999 Apr. PMID 10199825
    2. The role of genes affected by human evolution marker GNA13 in schizophrenia. Xiang B, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2020 Mar 2. PMID 31676466
    3. Signaling mechanisms and physiological functions of G-protein Gα(13) in blood vessel formation, bone homeostasis, and cancer. Syrovatkina V, et al. Protein Sci, 2019 Feb. PMID 30345641, Free PMC Article
    4. Analysis of GNA13 Protein in Follicular Lymphoma and its Association With Poor Prognosis. Shimono J, et al. Am J Surg Pathol, 2018 Nov. PMID 30307409, Free PMC Article
    5. Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling. Maziarz M, et al. J Biol Chem, 2020 Dec 4. PMID 33109615, Free PMC Article

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
      Title: The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells through the regulation of P2RY10/GNA13.
    2. Overexpressed Galpha13 activates serum response factor through stoichiometric imbalance with Gbetagamma and mislocalization to the cytoplasm.
      Title: Overexpressed Gα13 activates serum response factor through stoichiometric imbalance with Gβγ and mislocalization to the cytoplasm.
    3. The role of genes affected by human evolution marker GNA13 in schizophrenia.
      Title: The role of genes affected by human evolution marker GNA13 in schizophrenia.
    4. GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
      Title: GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
    5. Divergent C-terminal motifs in Galpha12 and Galpha13 provide distinct mechanisms of effector binding and SRF activation.
      Title: Divergent C-terminal motifs in Gα12 and Gα13 provide distinct mechanisms of effector binding and SRF activation.
    6. Naturally occurring hotspot cancer mutations in Galpha13 promote oncogenic signaling.
      Title: Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling.
    7. Galphas directly drives PDZ-RhoGEF signaling to Cdc42.
      Title: Gα(s) directly drives PDZ-RhoGEF signaling to Cdc42.
    8. G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
      Title: G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3.
    9. these findings suggest that GNA13 drives CXCL5 expression by transactivating NF-kappaB in a Rho-dependent manner in prostate cancer cells.
      Title: Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB.
    10. Signaling mechanisms and physiological functions of G-protein Galpha13 in blood vessel formation, bone homeostasis, and cancer.
      Title: Signaling mechanisms and physiological functions of G-protein Gα(13) in blood vessel formation, bone homeostasis, and cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (71)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants and gene expression associated with white matter microstructure in the human brain.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC46138

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables D5 dopamine receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G-protein beta/gamma-subunit complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in branching involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fibroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynapse assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in brush border membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein subunit alpha-13
    Names
    g alpha-13
    guanine nucleotide binding protein (G protein), alpha 13
    heterotrimeric guanine nucleotide-binding protein 1N

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282425.2 → NP_001269354.1  guanine nucleotide-binding protein subunit alpha-13 isoform 2

      See identical proteins and their annotated locations for NP_001269354.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in the use of a downstream AUG compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC037487, AK302400, AW298099
      Consensus CDS
      CCDS62302.1
      UniProtKB/TrEMBL
      B4DWV9
      Related
      ENSP00000439647.1, ENST00000541118.1
      Conserved Domains (1) summary
      cd00066
      Location:1 → 276
      G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

    2. NM_006572.6 → NP_006563.2  guanine nucleotide-binding protein subunit alpha-13 isoform 1

      See identical proteins and their annotated locations for NP_006563.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC037487, AF493902, AW298099, DC335364
      Consensus CDS
      CCDS11661.1
      UniProtKB/Swiss-Prot
      B2R977, B7Z7R0, F5H1G8, Q14344, Q8TD70
      UniProtKB/TrEMBL
      B4DWV9
      Related
      ENSP00000400717.2, ENST00000439174.7
      Conserved Domains (1) summary
      smart00275
      Location:29 → 375
      G_alpha; G protein alpha subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      65009289..65056740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      65879260..65926708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14344.2 GenPept UniProtKB/Swiss-Prot:Q14344

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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