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    FAM163B family with sequence similarity 163 member B [ Homo sapiens (human) ]

    Gene ID: 642968, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FAM163Bprovided by HGNC
    Official Full Name
    family with sequence similarity 163 member Bprovided by HGNC
    Primary source
    HGNC:HGNC:33277
    See related
    Ensembl:ENSG00000196990 AllianceGenome:HGNC:33277
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf166
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in brain (RPKM 9.7) and adrenal (RPKM 1.9) See more
    Orthologs
    mouse all
    NEW
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    Genomic context

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    See FAM163B in Genome Data Viewer
    Location:
    9q34.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (133577081..133609389, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (145791075..145825393, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136442203..136474511, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136385034-136385534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136395091-136395596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136398691-136399232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136399233-136399772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136399773-136400314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136400855-136401396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136401937-136402476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136404277-136405008 Neighboring gene myomaker, myoblast fusion factor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136405742-136406473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136407445-136407945 Neighboring gene ADAMTS like 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136410411-136411066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136420460-136420962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136420963-136421464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136421967-136422468 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136436438-136437078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136442732-136443347 Neighboring gene uncharacterized LOC124902296 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:136457531-136458030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136480627-136481226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136502750-136503485 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:136519605-136520404 Neighboring gene dopamine beta-hydroxylase Neighboring gene DBH antisense RNA 1 Neighboring gene SARDH intron CAGE-defined T cell enhancer Neighboring gene sarcosine dehydrogenase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136550530-136551030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136576505-136577208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136580725-136581428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136581429-136582130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:136592563-136593073

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Unknown genes, Cebelin and Cebelin-like, predominantly expressed in mouse brain. Miwa H, et al. Heliyon, 2018 Sep. PMID 30294689, Free PMC Article
    2. Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes. Ivarsson Y, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550280, Free PMC Article
    3. Proteome-wide analysis of phospho-regulated PDZ domain interactions. Sundell GN, et al. Mol Syst Biol, 2018 Aug 20. PMID 30126976, Free PMC Article
    4. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
    5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM163B
    Names
    cebelin-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080515.3 → NP_001073984.1  protein FAM163B

      See identical proteins and their annotated locations for NP_001073984.1

      Status: VALIDATED

      Source sequence(s)
      AC002101, BX629352
      Consensus CDS
      CCDS35171.1
      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Related
      ENSP00000501259.1, ENST00000673969.1
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    2. NM_001371529.1 → NP_001358458.1  protein FAM163B

      Status: VALIDATED

      Source sequence(s)
      BX629352
      Consensus CDS
      CCDS35171.1
      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Related
      ENSP00000419867.1, ENST00000496132.2
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      133577081..133609389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423715.1 → XP_047279671.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    2. XM_047423714.1 → XP_047279670.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    3. XM_047423716.1 → XP_047279672.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    4. XM_047423718.1 → XP_047279674.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    5. XM_005272204.5 → XP_005272261.1  protein FAM163B isoform X1

      See identical proteins and their annotated locations for XP_005272261.1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    6. XM_047423717.1 → XP_047279673.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    7. XM_017015017.2 → XP_016870506.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    8. XM_011518912.3 → XP_011517214.1  protein FAM163B isoform X1

      See identical proteins and their annotated locations for XP_011517214.1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    9. XM_006717233.4 → XP_006717296.1  protein FAM163B isoform X1

      See identical proteins and their annotated locations for XP_006717296.1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
      Conserved Domains (1) summary
      pfam15069
      Location:1 → 165
      FAM163; FAM163 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      145791075..145825393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363518.1 → XP_054219493.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    2. XM_054363517.1 → XP_054219492.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    3. XM_054363520.1 → XP_054219495.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    4. XM_054363521.1 → XP_054219496.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3

    5. XM_054363519.1 → XP_054219494.1  protein FAM163B isoform X1

      UniProtKB/Swiss-Prot
      B2RUZ5, P0C2L3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C2L3.1 GenPept UniProtKB/Swiss-Prot:P0C2L3

    Gene LinkOut

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