U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZDHHC24 zinc finger DHHC-type containing 24 [ Homo sapiens (human) ]

    Gene ID: 254359, updated on 14-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZDHHC24provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 24provided by HGNC
    Primary source
    HGNC:HGNC:27387
    See related
    Ensembl:ENSG00000174165 AllianceGenome:HGNC:27387
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in spleen (RPKM 1.8), kidney (RPKM 1.8) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ZDHHC24 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66520625..66546048, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66516865..66542290, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66288096..66313519, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66243741-66244561 Neighboring gene pellino E3 ubiquitin protein ligase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66245199-66245792 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66246731-66247298 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5045 Neighboring gene DPP3 divergent transcript Neighboring gene skeletal muscle cis-regulatory module in DPP3 intron Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66258390-66259340 Neighboring gene dipeptidyl peptidase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5046 Neighboring gene Bardet-Biedl syndrome 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298267-66298846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66298847-66299424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66307071-66307841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5047 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5049 Neighboring gene Sharpr-MPRA regulatory region 1034 Neighboring gene actinin alpha 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66332233-66332732 Neighboring gene cathepsin F

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    probable palmitoyltransferase ZDHHC24
    Names
    DHHC-24
    zinc finger DHHC domain-containing protein 24
    zinc finger, DHHC domain containing 24
    NP_001335500.1
    NP_997223.1
    XP_005273931.1
    XP_011543195.1
    XP_011543196.1
    XP_047282665.1
    XP_047282666.1
    XP_054224277.1
    XP_054224278.1
    XP_054224279.1
    XP_054224280.1
    XP_054224281.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348571.2 → NP_001335500.1  probable palmitoyltransferase ZDHHC24 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK310561, AP002748
      Consensus CDS
      CCDS86218.1
      UniProtKB/TrEMBL
      E9PLR9
      Related
      ENSP00000431321.1, ENST00000526986.5
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_207340.3 → NP_997223.1  probable palmitoyltransferase ZDHHC24 isoform 1

      See identical proteins and their annotated locations for NP_997223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AP002748, AY358448
      Consensus CDS
      CCDS8143.1
      UniProtKB/Swiss-Prot
      Q6PEW7, Q6UX98, Q9BSJ0
      UniProtKB/TrEMBL
      B4DX31
      Related
      ENSP00000309429.3, ENST00000310442.5
      Conserved Domains (1) summary
      pfam01529
      Location:95 → 234
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66520625..66546048 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273874.5 → XP_005273931.1  probable palmitoyltransferase ZDHHC24 isoform X3

      See identical proteins and their annotated locations for XP_005273931.1

      UniProtKB/TrEMBL
      E9PI61
      Related
      ENSP00000436503.1, ENST00000534073.5
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    2. XM_047426710.1 → XP_047282666.1  probable palmitoyltransferase ZDHHC24 isoform X4

    3. XM_011544894.3 → XP_011543196.1  probable palmitoyltransferase ZDHHC24 isoform X3

      See identical proteins and their annotated locations for XP_011543196.1

      UniProtKB/TrEMBL
      E9PI61
      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_047426709.1 → XP_047282665.1  probable palmitoyltransferase ZDHHC24 isoform X1

    5. XM_011544893.4 → XP_011543195.1  probable palmitoyltransferase ZDHHC24 isoform X2

      Conserved Domains (1) summary
      cl19890
      Location:95 → 169
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_007062470.1 RNA Sequence

    2. XR_949860.4 RNA Sequence

    3. XR_007062471.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66516865..66542290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368304.1 → XP_054224279.1  probable palmitoyltransferase ZDHHC24 isoform X3

      UniProtKB/TrEMBL
      E9PI61

    2. XM_054368306.1 → XP_054224281.1  probable palmitoyltransferase ZDHHC24 isoform X4

    3. XM_054368305.1 → XP_054224280.1  probable palmitoyltransferase ZDHHC24 isoform X3

      UniProtKB/TrEMBL
      E9PI61

    4. XM_054368302.1 → XP_054224277.1  probable palmitoyltransferase ZDHHC24 isoform X1

    5. XM_054368303.1 → XP_054224278.1  probable palmitoyltransferase ZDHHC24 isoform X2

    RNA

    1. XR_008488376.1 RNA Sequence

    2. XR_008488378.1 RNA Sequence

    3. XR_008488377.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UX98.1 GenPept UniProtKB/Swiss-Prot:Q6UX98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools