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    ITGA11 integrin subunit alpha 11 [ Homo sapiens (human) ]

    Gene ID: 22801, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ITGA11provided by HGNC
    Official Full Name
    integrin subunit alpha 11provided by HGNC
    Primary source
    HGNC:HGNC:6136
    See related
    Ensembl:ENSG00000137809 MIM:604789; AllianceGenome:HGNC:6136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT18964
    Summary
    This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in endometrium (RPKM 12.1), urinary bladder (RPKM 2.7) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ITGA11 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (68296532..68432163, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66115251..66255043, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (68588870..68724502, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903593 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:68564472-68565671 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:68570079-68570980 Neighboring gene NANOG hESC enhancer GRCh37_chr15:68577826-68578327 Neighboring gene fem-1 homolog B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68607402-68608268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68609715-68610215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68634197-68634792 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:68657127-68658326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68662273-68662774 Neighboring gene Sharpr-MPRA regulatory region 14581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:68722903-68723662 Neighboring gene Sharpr-MPRA regulatory region 1870 Neighboring gene uncharacterized LOC124903513 Neighboring gene uncharacterized LOC105370873

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation. Erusappan P, et al. Sci Rep, 2019 Oct 25. PMID 31653900, Free PMC Article
    2. Collagen-binding α11 integrin expression in human myometrium and fibroids utilizing a novel RNA in situ probe. Peavey M, et al. Reprod Sci, 2014 Sep. PMID 24520080, Free PMC Article
    3. Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases. Bansal R, et al. Exp Mol Med, 2017 Nov 17. PMID 29147013, Free PMC Article
    4. The role of Protein Disulfide Isomerase and thiol bonds modifications in activation of integrin subunit alpha11. Popielarski M, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29203246
    5. Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer. Schnittert J, et al. FASEB J, 2019 May. PMID 30808244

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
      Title: PDGFRα(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay.
    2. Osteosarcoma Cells Secrete CXCL14 That Activates Integrin alpha11beta1 on Fibroblasts to Form a Lung Metastatic Niche.
      Title: Osteosarcoma Cells Secrete CXCL14 That Activates Integrin α11β1 on Fibroblasts to Form a Lung Metastatic Niche.
    3. Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin alpha11 expression.
      Title: Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression.
    4. Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
      Title: Inhibition of integrin subunit alpha 11 restrains gastric cancer progression through phosphatidylinositol 3-kinase/Akt pathway.
    5. Long noncoding RNA FEZF1AS1 facilitates nonsmall cell lung cancer progression via the ITGA11/miR516b5p axis.
      Title: Long non‑coding RNA FEZF1‑AS1 facilitates non‑small cell lung cancer progression via the ITGA11/miR‑516b‑5p axis.
    6. p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating alpha1 integrin expression.
      Title: p75NTR optimizes the osteogenic potential of human periodontal ligament stem cells by up-regulating α1 integrin expression.
    7. Integrin alpha11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
      Title: Integrin α11 cytoplasmic tail is required for FAK activation to initiate 3D cell invasion and ERK-mediated cell proliferation.
    8. integrin alpha11 pro-invasive activity relies on its ability to interact with PDGFRbeta in a ligand-dependent manner and to promote its downstream JNK activation, leading to the production of tenascin C, a pro-invasive matricellular protein.
      Title: Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression.
    9. this study presents ITGA11 as an interesting stromal therapeutic target that plays a crucial role in the regulation of the differentiation of Pancreatic stellate cells into cancer-associated fibroblasts and paracrine effects.
      Title: Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.
    10. Data show that integrin alpha-11 (integrin alpha11) is a physiologically important receptor for Osteolectin, mediating its effect on osteogenesis.
      Title: Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass.
    Submit: New GeneRIF Correction See all GeneRIFs (30)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables collagen binding involved in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables collagen receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables integrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in osteoblast differentiation HDA PubMed 
    involved_in substrate-dependent cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin alpha11-beta1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of integrin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane HDA PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    integrin alpha-11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046911.1 RefSeqGene

      Range
      4998..140629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004439.2 → NP_001004439.1  integrin alpha-11 precursor

      See identical proteins and their annotated locations for NP_001004439.1

      Status: REVIEWED

      Source sequence(s)
      AC021553, AC100825, AF109681, AF137378, AK095863, AL359064, BX496541, CN358985
      Consensus CDS
      CCDS45291.1
      UniProtKB/Swiss-Prot
      J3KQM2, Q8WYI8, Q9UKQ1, Q9UKX5
      UniProtKB/TrEMBL
      A8K8T0
      Related
      ENSP00000327290.7, ENST00000315757.9
      Conserved Domains (3) summary
      smart00191
      Location:538 → 592
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:163 → 341
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:635 → 1034
      Integrin_alpha2; Integrin alpha

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      68296532..68432163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521363.3 → XP_011519665.1  integrin alpha-11 isoform X1

      UniProtKB/TrEMBL
      A8K8T0
      Conserved Domains (3) summary
      smart00191
      Location:469 → 523
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:94 → 272
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:566 → 965
      Integrin_alpha2; Integrin alpha

    2. XM_005254228.4 → XP_005254285.1  integrin alpha-11 isoform X2

      UniProtKB/TrEMBL
      A8K8T0
      Conserved Domains (3) summary
      smart00191
      Location:436 → 490
      Int_alpha; Integrin alpha (beta-propellor repeats)
      cd01469
      Location:61 → 239
      vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
      pfam08441
      Location:533 → 932
      Integrin_alpha2; Integrin alpha

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      66115251..66255043 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_012211.3: Suppressed sequence

      Description
      NM_012211.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UKX5.2 GenPept UniProtKB/Swiss-Prot:Q9UKX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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