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    ZNF70 zinc finger protein 70 [ Homo sapiens (human) ]

    Gene ID: 7621, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF70provided by HGNC
    Official Full Name
    zinc finger protein 70provided by HGNC
    Primary source
    HGNC:HGNC:13140
    See related
    Ensembl:ENSG00000187792 MIM:194544; AllianceGenome:HGNC:13140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cos17
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytoplasm and megasporocyte nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 2.8), thyroid (RPKM 1.7) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF70 in Genome Data Viewer
    Location:
    22q11.23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23738682..23751112, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24185879..24199262, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24080869..24093299, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene GUSB pseudogene 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24037607-24038107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18756 Neighboring gene ral guanine nucleotide dissociation stimulator like 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24059101-24059740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24059741-24060380 Neighboring gene uncharacterized LOC124905088 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene V-set pre-B cell surrogate light chain 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene chromosome 22 open reading frame 15 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation. Han GL, et al. Anticancer Drugs, 2020 Mar. PMID 32053575
    2. ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer. Zhang Z, et al. Cell Signal, 2024 Feb. PMID 38000525
    3. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Aubry M, et al. Genomics, 1992 Jul. PMID 1639391
    4. ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression. Watanabe K, et al. Biochem Biophys Res Commun, 2016 Sep 2. PMID 27353377
    5. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF70 regulates IL-1beta secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer.
      Title: ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer.
    2. miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation.
      Title: miRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation.
    3. We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee
      Title: ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ44547, MGC48959

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in megasporocyte nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 70
    Names
    zinc finger protein N27C7-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021916.4 → NP_068735.1  zinc finger protein 70

      See identical proteins and their annotated locations for NP_068735.1

      Status: VALIDATED

      Source sequence(s)
      AK122721, AP000348, BC040161
      Consensus CDS
      CCDS13812.1
      UniProtKB/Swiss-Prot
      Q9UC06
      Related
      ENSP00000339314.3, ENST00000341976.5
      Conserved Domains (2) summary
      COG5048
      Location:138 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23738682..23751112 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441490.1 → XP_047297446.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06

    2. XM_024452271.2 → XP_024308039.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06
      Conserved Domains (2) summary
      COG5048
      Location:138 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_024452270.2 → XP_024308038.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06
      Conserved Domains (2) summary
      COG5048
      Location:138 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_024452269.2 → XP_024308037.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06
      Conserved Domains (2) summary
      COG5048
      Location:138 → 442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24185879..24199262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325902.1 → XP_054181877.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06

    2. XM_054325904.1 → XP_054181879.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06

    3. XM_054325903.1 → XP_054181878.1  zinc finger protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q9UC06
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UC06.2 GenPept UniProtKB/Swiss-Prot:Q9UC06

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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