ADRA1A adrenoceptor alpha 1A [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADRA1Aprovided by HGNC
Official Full Name: adrenoceptor alpha 1Aprovided by HGNC
Primary source: HGNC:HGNC:277
See related: Ensembl:ENSG00000120907 MIM:104221; AllianceGenome:HGNC:277
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADRA1C; ADRA1L1; ALPHA1AAR
Summary: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Expression: Biased expression in fat (RPKM 3.7), liver (RPKM 3.6) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p21.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (26748150..26867379, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (27024936..27144213, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (26605667..26724795, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway.
Title: Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway.
Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
Title: Alpha1A- and Beta3-Adrenoceptors Interplay in Adipose Multipotent Mesenchymal Stromal Cells: A Novel Mechanism of Obesity-Driven Hypertension.
Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese.
Title: Hypermethylation in the promoter region of the ADRA1A gene is associated with opioid use disorder in Han Chinese.
Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes.
Title: Vascular Reactions of the Diving Reflex in Men and Women Carrying Different ADRA1A Genotypes.
MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A.
Title: MiR-3682 promotes the progression of hepatocellular carcinoma (HCC) via inactivating AMPK signaling by targeting ADRA1A.
Role of alpha- and beta-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Title: Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder.
Title: Association study of Catechol-o-methyltransferase and Alpha-1-adrenergic receptor gene polymorphisms with multiple phenotypes of heroin use disorder.
Deacetylation as a receptor-regulated direct activation switch for pannexin channels.
Title: Deacetylation as a receptor-regulated direct activation switch for pannexin channels.
Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers.
Title: Class A G protein-coupled receptors assemble into functional higher-order hetero-oligomers.
Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma.
Title: Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (84)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC35558 (e-PCR)
- UniSTS:34325

D10S275 (e-PCR)
- UniSTS:147992

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

D8S2033 (e-PCR)
- UniSTS:81797

RH45859 (e-PCR)
- UniSTS:77192

D11S3114 (e-PCR)
- UniSTS:152207

WI-17142 (e-PCR)
- UniSTS:76956

SGC35557 (e-PCR)
- UniSTS:8124

NoName (e-PCR)
- UniSTS:485346

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha1-adrenergic receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables alpha1-adrenergic receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adult heart development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in neuron-glial cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in pilomotor reflex	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle hypertrophy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart rate by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, GABAergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of the force of heart contraction by epinephrine-norepinephrine	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in smooth muscle contraction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: alpha-1A adrenergic receptor

Names: G protein coupled receptor; alpha-1A adrenoceptor; alpha-1A adrenoreceptor; alpha-1C adrenergic receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029395.1 RefSeqGene

Range

3128..101597

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000680.4 → NP_000671.2 alpha-1A adrenergic receptor isoform 1

See identical proteins and their annotated locations for NP_000671.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) is alternatively spliced in the 3' end, compared to variant 3. It encodes isoform 1, which has a longer and distinct C-terminus compared to isoform 3.

Source sequence(s)

AA383170, AC022839, AC091675, AK289548, AK311558, BF475837, D25235, HY277084

Consensus CDS

CCDS6054.1

UniProtKB/Swiss-Prot

A8K0I3, B0ZBD1, B0ZBD2, B0ZBD4, B0ZBD5, B0ZBD6, B0ZBD8, B0ZBD9, O60451, P35348, Q13675, Q13729, Q4VBM7, Q6RUJ4, Q6RUJ5, Q6RUJ7, Q6RUJ8, Q6RUJ9, Q96RE8, Q9UD63, Q9UD67

UniProtKB/TrEMBL

E7EW16

Related

ENSP00000369947.3, ENST00000380573.4

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
NM_001322502.1 → NP_001309431.1 alpha-1A adrenergic receptor isoform 5

Status: REVIEWED

Source sequence(s)

AA568306, AC015564, AC022839, AK289548, AK311558, AY491778, BX101935

UniProtKB/Swiss-Prot

P35348

Conserved Domains (2) summary

pfam00001
Location:43 → 300

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 224

7tm_4; Olfactory receptor
NM_001322503.1 → NP_001309432.1 alpha-1A adrenergic receptor isoform 6

Status: REVIEWED

Source sequence(s)

AC015564, AC022839, AK289548, AK311558, D32202

UniProtKB/Swiss-Prot

P35348

Conserved Domains (3) summary

pfam00001
Location:43 → 303

7tm_1; 7 transmembrane receptor (rhodopsin family)

pfam13900
Location:300 → 339

GVQW; Putative domain of unknown function

cl21561
Location:37 → 224

7tm_4; Olfactory receptor
NM_001322504.1 → NP_001309433.1 alpha-1A adrenergic receptor isoform 7

Status: REVIEWED

Source sequence(s)

AC022839, AC091675, AK289548, AK311558, AY491781

Consensus CDS

CCDS83269.1

UniProtKB/Swiss-Prot

P35348

Related

ENSP00000369946.3, ENST00000380572.3

Conserved Domains (2) summary

cd14964
Location:29 → 53

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 294

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_033302.3 → NP_150645.2 alpha-1A adrenergic receptor isoform 3

See identical proteins and their annotated locations for NP_150645.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) encodes isoform 3.

Source sequence(s)

AA568306, AC015564, AC022839, AC091675, AK289548, AK311558, BX101935, D32201

Consensus CDS

CCDS6052.1

UniProtKB/TrEMBL

E7EW16

Related

ENSP00000369956.3, ENST00000380582.7

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
NM_033303.4 → NP_150646.3 alpha-1A adrenergic receptor isoform 2

See identical proteins and their annotated locations for NP_150646.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 3.

Source sequence(s)

AC015564, AC022839, AC091675, AK289548, AK311558, D32202

Consensus CDS

CCDS34869.1

UniProtKB/TrEMBL

B0ZBD3, E7EW16

Related

ENSP00000369960.1, ENST00000380586.5

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
NM_033304.3 → NP_150647.2 alpha-1A adrenergic receptor isoform 4

See identical proteins and their annotated locations for NP_150647.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes an alternate 3' terminal exon, compared to variant 3. It encodes isoform 4, which has a longer and distinct C-terminus, compared to isoform 3.

Source sequence(s)

AC022839, AC091675, AF013261, AK289548, AK311558, D32201

Consensus CDS

CCDS6053.1

UniProtKB/TrEMBL

E7EW16

Related

ENSP00000346557.4, ENST00000354550.4

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor

RNA

NR_136343.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC015564, AC022839, AK289548, AK311558, AY491775, D32202

Related

ENST00000519096.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

26748150..26867379 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017013094.2 → XP_016868583.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/TrEMBL

B0ZBD3, E7EW16

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
XM_017013095.2 → XP_016868584.1 alpha-1A adrenergic receptor isoform X1

UniProtKB/TrEMBL

B0ZBD3, E7EW16

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
XM_006716293.5 → XP_006716356.1 alpha-1A adrenergic receptor isoform X2

See identical proteins and their annotated locations for XP_006716356.1

UniProtKB/TrEMBL

E7EW16

Conserved Domains (2) summary

pfam00001
Location:43 → 326

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 341

7tm_4; Olfactory receptor
XM_017013096.2 → XP_016868585.1 alpha-1A adrenergic receptor isoform X3
XM_011544412.4 → XP_011542714.1 alpha-1A adrenergic receptor isoform X4

Conserved Domains (2) summary

pfam00001
Location:43 → 295

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 224

7tm_4; Olfactory receptor