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    Cspp1 centrosome and spindle pole associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 211660, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cspp1provided by MGI
    Official Full Name
    centrosome and spindle pole associated protein 1provided by MGI
    Primary source
    MGI:MGI:2681832
    See related
    Ensembl:ENSMUSG00000056763 AllianceGenome:MGI:2681832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cspp2; Cspp3; 2310020J12Rik; 4930413O22Rik
    Summary
    Predicted to be involved in positive regulation of cytokinesis. Located in spindle pole. Is expressed in several structures, including adrenal gland; central nervous system; gonad; lung; and olfactory epithelium. Human ortholog(s) of this gene implicated in Joubert syndrome 21. Orthologous to human CSPP1 (centrosome and spindle pole associated protein 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 8.3), CNS E14 (RPKM 7.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cspp1 in Genome Data Viewer
    Location:
    1 A2; 1 2.3 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (10108194..10206996)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (10038116..10136771)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00178 Neighboring gene STARR-seq mESC enhancer starr_00179 Neighboring gene protein phosphatase 1, regulatory subunit 42 Neighboring gene transcription factor 24 Neighboring gene STARR-positive B cell enhancer ABC_E270 Neighboring gene predicted gene, 24674 Neighboring gene STARR-seq mESC enhancer starr_00181 Neighboring gene COP9 signalosome subunit 5 Neighboring gene STARR-seq mESC enhancer starr_00182 Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene carboxypeptidase A6 Neighboring gene STARR-seq mESC enhancer starr_00185 Neighboring gene heat shock protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel centrosome/microtubule-associated coiled-coil protein involved in cell-cycle progression and spindle organization. Patzke S, et al. Oncogene, 2005 Feb 10. PMID 15580290
    2. Centrosome/spindle pole-associated protein regulates cytokinesis via promoting the recruitment of MyoGEF to the central spindle. Asiedu M, et al. Mol Biol Cell, 2009 Mar. PMID 19129481, Free PMC Article
    3. Global gene expression analysis in fetal mouse ovaries with and without meiosis and comparison of selected genes with meiosis in the testis. Olesen C, et al. Cell Tissue Res, 2007 Apr. PMID 17431699
    4. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
    5. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosome and spindle pole associated protein 1
    Names
    centrosome/spindle pole-associated protein 2
    centrosome/spindle pole-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368816.1 → NP_001355745.1  centrosome and spindle pole associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC102570, AC159972
      Consensus CDS
      CCDS87812.1
      Related
      ENSMUSP00000139775.2, ENSMUST00000186294.7
      Conserved Domains (1) summary
      pfam13904
      Location:569 → 693
      DUF4207; Domain of unknown function (DUF4207)

    2. NM_026493.3 → NP_080769.3  centrosome and spindle pole associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080769.3

      Status: VALIDATED

      Source sequence(s)
      AC102570, AC159972, BB042416, BE943955, BM949181, BP768397, CN457021, CN459376, CO426461
      Consensus CDS
      CCDS35511.1
      UniProtKB/Swiss-Prot
      B2RX88
      Related
      ENSMUSP00000068804.6, ENSMUST00000071087.12

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      10108194..10206996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163249.1 → XP_036019142.1  centrosome and spindle pole associated protein 1 isoform X1

    2. XM_036163256.1 → XP_036019149.1  centrosome and spindle pole associated protein 1 isoform X4

    3. XM_006495479.5 → XP_006495542.3  centrosome and spindle pole associated protein 1 isoform X3

    4. XM_006495481.5 → XP_006495544.3  centrosome and spindle pole associated protein 1 isoform X5

      Conserved Domains (1) summary
      pfam13904
      Location:653 → 776
      DUF4207; Domain of unknown function (DUF4207)

    5. XM_036163286.1 → XP_036019179.1  centrosome and spindle pole associated protein 1 isoform X18

    6. XM_006495485.4 → XP_006495548.3  centrosome and spindle pole associated protein 1 isoform X13

    7. XM_030252691.1 → XP_030108551.1  centrosome and spindle pole associated protein 1 isoform X15

      Conserved Domains (1) summary
      pfam13904
      Location:481 → 604
      DUF4207; Domain of unknown function (DUF4207)

    8. XM_036163251.1 → XP_036019144.1  centrosome and spindle pole associated protein 1 isoform X2

    9. XM_030252675.1 → XP_030108535.1  centrosome and spindle pole associated protein 1 isoform X7

      Conserved Domains (1) summary
      pfam13904
      Location:645 → 768
      DUF4207; Domain of unknown function (DUF4207)

    10. XM_030252689.1 → XP_030108549.1  centrosome and spindle pole associated protein 1 isoform X14

    11. XM_036163261.1 → XP_036019154.1  centrosome and spindle pole associated protein 1 isoform X6

    12. XM_006495482.5 → XP_006495545.1  centrosome and spindle pole associated protein 1 isoform X9

      See identical proteins and their annotated locations for XP_006495545.1

      UniProtKB/Swiss-Prot
      B2RX88, C7SBE3, C7SBE4, Q8CCQ4, Q8VE83, Q9CQD5

    13. XM_036163267.1 → XP_036019160.1  centrosome and spindle pole associated protein 1 isoform X11

    14. XM_036163260.1 → XP_036019153.1  centrosome and spindle pole associated protein 1 isoform X6

    15. XM_017319604.2 → XP_017175093.1  centrosome and spindle pole associated protein 1 isoform X16

    16. XM_036163262.1 → XP_036019155.1  centrosome and spindle pole associated protein 1 isoform X8

    17. XM_006495483.4 → XP_006495546.1  centrosome and spindle pole associated protein 1 isoform X10

      See identical proteins and their annotated locations for XP_006495546.1

      UniProtKB/Swiss-Prot
      B2RX88

    18. XM_030252688.2 → XP_030108548.1  centrosome and spindle pole associated protein 1 isoform X12

      Conserved Domains (1) summary
      pfam13904
      Location:573 → 696
      DUF4207; Domain of unknown function (DUF4207)

    19. XM_017319609.2 → XP_017175098.1  centrosome and spindle pole associated protein 1 isoform X20

      Conserved Domains (1) summary
      pfam13904
      Location:59 → 182
      DUF4207; Domain of unknown function (DUF4207)

    20. XM_036163264.1 → XP_036019157.1  centrosome and spindle pole associated protein 1 isoform X8

    21. XM_030252692.2 → XP_030108552.1  centrosome and spindle pole associated protein 1 isoform X17

    22. XM_036163294.1 → XP_036019187.1  centrosome and spindle pole associated protein 1 isoform X19

    RNA

    1. XR_004941385.1 RNA Sequence

    2. XR_004941384.1 RNA Sequence

    3. XR_004941386.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RX88.2 GenPept UniProtKB/Swiss-Prot:B2RX88

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