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    ANGPTL2 angiopoietin like 2 [ Homo sapiens (human) ]

    Gene ID: 23452, updated on 28-Oct-2024

    Summary

    Official Symbol
    ANGPTL2provided by HGNC
    Official Full Name
    angiopoietin like 2provided by HGNC
    Primary source
    HGNC:HGNC:490
    See related
    Ensembl:ENSG00000136859 MIM:605001; AllianceGenome:HGNC:490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARP2; HARP
    Summary
    Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ANGPTL2 in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (127087348..127122635, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (139293792..139329078, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (129849627..129884914, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20294 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129623061-129623858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129630751-129631332 Neighboring gene NANOG hESC enhancer GRCh37_chr9:129645854-129646429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129648667-129649167 Neighboring gene zinc finger and BTB domain containing 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29025 Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29031 Neighboring gene uncharacterized LOC105376279 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129792702-129793202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:129829482-129829982 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129874135-129874746 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129884227-129884860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129884861-129885494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129885495-129886128 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29032 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:129920824-129922023 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:129928436-129929635 Neighboring gene uncharacterized LOC105376278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129943177-129943676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129946409-129946979 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129948384-129948884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29034 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129957118-129957618 Neighboring gene Sharpr-MPRA regulatory region 1494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129961533-129962521 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129969788-129970288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129970289-129970789 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129972323-129972840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129974395-129974912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129978722-129979222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129979223-129979723 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:129981929-129982488 Neighboring gene uncharacterized LOC124902273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129985710-129986210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:129986211-129986711

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with ANGPTL2; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC8889

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    angiopoietin-related protein 2
    Names
    angiopoietin-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012098.3NP_036230.1  angiopoietin-related protein 2 precursor

      See identical proteins and their annotated locations for NP_036230.1

      Status: REVIEWED

      Source sequence(s)
      AK074726, AL356862, AL598400, BC012368
      Consensus CDS
      CCDS6868.1
      UniProtKB/Swiss-Prot
      Q5JT58, Q8NCH7, Q9UKU9
      UniProtKB/TrEMBL
      B2R780
      Related
      ENSP00000362524.3, ENST00000373425.8
      Conserved Domains (1) summary
      cd00087
      Location:273487
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      127087348..127122635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717030.5XP_006717093.1  angiopoietin-related protein 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      139293792..139329078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362559.1XP_054218534.1  angiopoietin-related protein 2 isoform X1