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    STYK1 serine/threonine/tyrosine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 55359, updated on 2-Nov-2024

    Summary

    Official Symbol
    STYK1provided by HGNC
    Official Full Name
    serine/threonine/tyrosine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:18889
    See related
    Ensembl:ENSG00000060140 MIM:611433; AllianceGenome:HGNC:18889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOK; SuRTK106
    Summary
    Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in colon (RPKM 5.3), stomach (RPKM 4.5) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STYK1 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10618923..10674052, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10492227..10547157, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10771522..10826651, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2446 Neighboring gene uncharacterized LOC105376675 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:10724334-10724939 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:10733376-10734575 Neighboring gene killer cell lectin like receptor A1, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:10765265-10766144 and GRCh37_chr12:10766145-10767022 Neighboring gene mago homolog B, exon junction complex subunit Neighboring gene Y-box binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4238 Neighboring gene uncharacterized LOC124902876 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4240 Neighboring gene uncharacterized LOC112268104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5963

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp761P1010

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase STYK1
    Names
    novel oncogene with kinase domain
    protein PK-unique
    NP_060893.2
    XP_005253474.1
    XP_011519038.1
    XP_011519039.1
    XP_011519040.1
    XP_047285055.1
    XP_054228427.1
    XP_054228428.1
    XP_054228429.1
    XP_054228430.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018423.3NP_060893.2  tyrosine-protein kinase STYK1

      See identical proteins and their annotated locations for NP_060893.2

      Status: VALIDATED

      Source sequence(s)
      AC021049, AF251059, AL353940
      Consensus CDS
      CCDS8629.1
      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Related
      ENSP00000075503.3, ENST00000075503.8
      Conserved Domains (2) summary
      pfam07714
      Location:117380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118381
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10618923..10674052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005253417.3XP_005253474.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_005253474.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118381
      PKc_like; Protein Kinases, catalytic domain
    2. XM_047429099.1XP_047285055.1  tyrosine-protein kinase STYK1 isoform X2

    3. XM_011520736.2XP_011519038.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519038.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118381
      PKc_like; Protein Kinases, catalytic domain
    4. XM_011520738.3XP_011519040.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519040.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118381
      PKc_like; Protein Kinases, catalytic domain
    5. XM_011520737.2XP_011519039.1  tyrosine-protein kinase STYK1 isoform X1

      See identical proteins and their annotated locations for XP_011519039.1

      UniProtKB/Swiss-Prot
      B2R9T2, Q52LR3, Q6J9G0, Q9BXY2, Q9NSH1
      UniProtKB/TrEMBL
      A0A0C5BIK5
      Conserved Domains (2) summary
      pfam07714
      Location:117380
      Pkinase_Tyr; Protein tyrosine kinase
      cl21453
      Location:118381
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10492227..10547157 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372452.1XP_054228427.1  tyrosine-protein kinase STYK1 isoform X1

    2. XM_054372455.1XP_054228430.1  tyrosine-protein kinase STYK1 isoform X2

    3. XM_054372453.1XP_054228428.1  tyrosine-protein kinase STYK1 isoform X1

    4. XM_054372454.1XP_054228429.1  tyrosine-protein kinase STYK1 isoform X1