U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HTR5A 5-hydroxytryptamine receptor 5A [ Homo sapiens (human) ]

    Gene ID: 3361, updated on 28-Oct-2024

    Summary

    Official Symbol
    HTR5Aprovided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 5Aprovided by HGNC
    Primary source
    HGNC:HGNC:5300
    See related
    Ensembl:ENSG00000157219 MIM:601305; AllianceGenome:HGNC:5300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT5A
    Summary
    The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 2.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HTR5A in Genome Data Viewer
    Location:
    7q36.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (155070324..155087392)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (156245922..156265002)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (154862034..154879102)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene PAX interacting protein 1 Neighboring gene uncharacterized LOC124901781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18839 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18841 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154795729-154796230 Neighboring gene PAXIP1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:154862583-154863409 Neighboring gene HTR5A antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:154914484-154915093 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959387-154959888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:154959889-154960388 Neighboring gene uncharacterized LOC105375584 Neighboring gene RN7SK pseudogene 280

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of the five-factor model of personality in young Korean women.
    EBI GWAS Catalog
    Genome-wide interaction study of smoking and bladder cancer risk.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138226

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Gi/o-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic specialization membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    5-hydroxytryptamine receptor 5A
    Names
    5-HT-5
    5-HT-5A
    5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_044997.1 RefSeqGene

      Range
      5001..22069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1057

    mRNA and Protein(s)

    1. NM_024012.4NP_076917.1  5-hydroxytryptamine receptor 5A

      See identical proteins and their annotated locations for NP_076917.1

      Status: REVIEWED

      Source sequence(s)
      AC092628, AC093726, BC112021, BX538209
      Consensus CDS
      CCDS5936.1
      UniProtKB/Swiss-Prot
      P47898, Q2M2D2
      UniProtKB/TrEMBL
      A4D2N2, Q14D80
      Related
      ENSP00000287907.2, ENST00000287907.3
      Conserved Domains (1) summary
      cd15328
      Location:41349
      7tmA_5-HT5; serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      155070324..155087392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      156245922..156265002
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008487586.1 RNA Sequence