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    ZMIZ2 zinc finger MIZ-type containing 2 [ Homo sapiens (human) ]

    Gene ID: 83637, updated on 28-Oct-2024

    Summary

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    Official Symbol
    ZMIZ2provided by HGNC
    Official Full Name
    zinc finger MIZ-type containing 2provided by HGNC
    Primary source
    HGNC:HGNC:22229
    See related
    Ensembl:ENSG00000122515 MIM:611196; AllianceGenome:HGNC:22229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET27; ZIMP7; hZIMP7; TRAFIP20
    Summary
    ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 17.3), skin (RPKM 13.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZMIZ2 in Genome Data Viewer
    Location:
    7p13
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44748571..44769881)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44909114..44930427)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44788170..44809480)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18147 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44646637-44647200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18148 Neighboring gene oxoglutarate dehydrogenase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25949 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44674956-44675111 Neighboring gene OGDH intron CAGE-defined high expression enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25951 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:44679045-44679572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44685039-44685539 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44717745-44717958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44740093-44740593 Neighboring gene uncharacterized LOC124901622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44794273-44794954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44807583-44808109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44826409-44826913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44826914-44827417 Neighboring gene uncharacterized LOC105375259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18154 Neighboring gene peptidylprolyl isomerase A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer. Gan X, et al. Cell Mol Biol Lett, 2024 Sep 12. PMID 39266996, Free PMC Article
    2. The novel PIAS-like protein hZimp10 is a transcriptional co-activator of the p53 tumor suppressor. Lee J, et al. Nucleic Acids Res, 2007. PMID 17584785, Free PMC Article
    3. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Huang CY, et al. Mol Endocrinol, 2005 Dec. PMID 16051670
    4. A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription. Peng Y, et al. J Biol Chem, 2010 Apr 9. PMID 20159969, Free PMC Article
    5. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin. Zhu Y, et al. Cell Death Differ, 2020 Apr. PMID 31527801, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer.
      Title: Identification of zinc finger MIZ-type containing 2 as an oncoprotein enhancing NAD-dependent protein deacetylase sirtuin-1 deacetylase activity to regulate Wnt and Hippo pathways in non-small-cell lung cancer.
    2. LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of beta-catenin.
      Title: LINC00265 promotes colorectal tumorigenesis via ZMIZ2 and USP7-mediated stabilization of β-catenin.
    3. there is an interaction between Zimp7 and PIAS proteins with higher preference for PIAS3, in androgen receptor-mediated transcription
      Title: A novel role for protein inhibitor of activated STAT (PIAS) proteins in modulating the activity of Zimp7, a novel PIAS-like protein, in androgen receptor-mediated transcription.
    4. hZimp7 modulates androgen receptor and/or other nuclear receptor-mediated transcription, possibly through alteration of chromatin structure by SWI/SNF-like BAF complexes.
      Title: hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1886, DKFZp761I2123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger MIZ domain-containing protein 2
    Names
    PIAS-like protein Zimp7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300959.2 → NP_001287888.1  zinc finger MIZ domain-containing protein 2 isoform 3

      See identical proteins and their annotated locations for NP_001287888.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AI494261, AK057378, AL831933, BC110435, HY060154
      Consensus CDS
      CCDS75591.1
      UniProtKB/TrEMBL
      D4YW75
      Related
      ENSP00000409648.1, ENST00000413916.5
      Conserved Domains (2) summary
      PHA03247
      Location:169 → 330
      PHA03247; large tegument protein UL36; Provisional
      cd16791
      Location:539 → 586
      SP-RING_ZMIZ; SP-RING finger found in zinc finger MIZ domain-containing protein Zmiz1, Zmiz2, and similar proteins

    2. NM_031449.4 → NP_113637.3  zinc finger MIZ domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_113637.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest isoform (1).
      Source sequence(s)
      AC004859, AK090415, AK128359, AY426594, BI115680, CD367243
      Consensus CDS
      CCDS43576.1
      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7
      UniProtKB/TrEMBL
      D4YW75
      Related
      ENSP00000311778.4, ENST00000309315.9
      Conserved Domains (1) summary
      pfam02891
      Location:596 → 644
      zf-MIZ; MIZ/SP-RING zinc finger

    3. NM_174929.2 → NP_777589.2  zinc finger MIZ domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_777589.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK057378, AK090415, AL831933, AY426594, BC016968, BC021924, CD367243
      Consensus CDS
      CCDS43577.1
      UniProtKB/TrEMBL
      D4YW75
      Related
      ENSP00000265346.7, ENST00000265346.11
      Conserved Domains (1) summary
      pfam02891
      Location:570 → 618
      zf-MIZ; MIZ/SP-RING zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      44748571..44769881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420896.1 → XP_047276852.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

    2. XM_047420891.1 → XP_047276847.1  zinc finger MIZ domain-containing protein 2 isoform X1

    3. XM_047420898.1 → XP_047276854.1  zinc finger MIZ domain-containing protein 2 isoform X3

    4. XM_047420902.1 → XP_047276858.1  zinc finger MIZ domain-containing protein 2 isoform X5

    5. XM_047420907.1 → XP_047276863.1  zinc finger MIZ domain-containing protein 2 isoform X8

    6. XM_005249866.3 → XP_005249923.1  zinc finger MIZ domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249923.1

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:605 → 653
      zf-MIZ; MIZ/SP-RING zinc finger

    7. XM_005249869.3 → XP_005249926.1  zinc finger MIZ domain-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_005249926.1

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7
      UniProtKB/TrEMBL
      D4YW75
      Related
      ENSP00000414723.1, ENST00000441627.5
      Conserved Domains (1) summary
      pfam02891
      Location:596 → 644
      zf-MIZ; MIZ/SP-RING zinc finger

    8. XM_005249870.3 → XP_005249927.1  zinc finger MIZ domain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:579 → 627
      zf-MIZ; MIZ/SP-RING zinc finger

    9. XM_005249872.3 → XP_005249929.1  zinc finger MIZ domain-containing protein 2 isoform X5

      See identical proteins and their annotated locations for XP_005249929.1

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:570 → 618
      zf-MIZ; MIZ/SP-RING zinc finger

    10. XM_005249871.3 → XP_005249928.1  zinc finger MIZ domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:573 → 621
      zf-MIZ; MIZ/SP-RING zinc finger

    11. XM_005249873.3 → XP_005249930.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      D4YW75, E7EWM3
      Conserved Domains (1) summary
      pfam02891
      Location:564 → 612
      zf-MIZ; MIZ/SP-RING zinc finger

    12. XM_047420895.1 → XP_047276851.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

    13. XM_047420903.1 → XP_047276859.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      E7EWM3
      Related
      ENSP00000396601.1, ENST00000433667.5

    14. XM_047420892.1 → XP_047276848.1  zinc finger MIZ domain-containing protein 2 isoform X1

    15. XM_047420893.1 → XP_047276849.1  zinc finger MIZ domain-containing protein 2 isoform X1

    16. XM_017012674.2 → XP_016868163.1  zinc finger MIZ domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:605 → 653
      zf-MIZ; MIZ/SP-RING zinc finger

    17. XM_047420897.1 → XP_047276853.1  zinc finger MIZ domain-containing protein 2 isoform X3

    18. XM_047420899.1 → XP_047276855.1  zinc finger MIZ domain-containing protein 2 isoform X5

    19. XM_047420904.1 → XP_047276860.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      E7EWM3

    20. XM_047420905.1 → XP_047276861.1  zinc finger MIZ domain-containing protein 2 isoform X7

    21. XM_047420906.1 → XP_047276862.1  zinc finger MIZ domain-containing protein 2 isoform X8

    22. XM_047420900.1 → XP_047276856.1  zinc finger MIZ domain-containing protein 2 isoform X5

    23. XM_005249867.6 → XP_005249924.1  zinc finger MIZ domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005249924.1

      UniProtKB/TrEMBL
      D4YW75
      Conserved Domains (1) summary
      pfam02891
      Location:605 → 653
      zf-MIZ; MIZ/SP-RING zinc finger

    24. XM_047420908.1 → XP_047276864.1  zinc finger MIZ domain-containing protein 2 isoform X9

    25. XM_011515566.2 → XP_011513868.1  zinc finger MIZ domain-containing protein 2 isoform X10

      UniProtKB/TrEMBL
      B3KR25
      Conserved Domains (1) summary
      pfam02891
      Location:331 → 379
      zf-MIZ; MIZ/SP-RING zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      44909114..44930427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359128.1 → XP_054215103.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

    2. XM_054359123.1 → XP_054215098.1  zinc finger MIZ domain-containing protein 2 isoform X1

    3. XM_054359127.1 → XP_054215102.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

    4. XM_054359131.1 → XP_054215106.1  zinc finger MIZ domain-containing protein 2 isoform X3

    5. XM_054359136.1 → XP_054215111.1  zinc finger MIZ domain-containing protein 2 isoform X5

    6. XM_054359137.1 → XP_054215112.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      E7EWM3

    7. XM_054359142.1 → XP_054215117.1  zinc finger MIZ domain-containing protein 2 isoform X8

    8. XM_054359120.1 → XP_054215095.1  zinc finger MIZ domain-containing protein 2 isoform X1

    9. XM_054359126.1 → XP_054215101.1  zinc finger MIZ domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      A4D2K7, D3DVL1, O94790, Q0VGB4, Q659A8, Q6JKL5, Q8NF64, Q8WTX8, Q96Q01, Q9BQH7

    10. XM_054359130.1 → XP_054215105.1  zinc finger MIZ domain-containing protein 2 isoform X3

    11. XM_054359134.1 → XP_054215109.1  zinc finger MIZ domain-containing protein 2 isoform X5

    12. XM_054359132.1 → XP_054215107.1  zinc finger MIZ domain-containing protein 2 isoform X4

    13. XM_054359138.1 → XP_054215113.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      E7EWM3

    14. XM_054359124.1 → XP_054215099.1  zinc finger MIZ domain-containing protein 2 isoform X1

    15. XM_054359125.1 → XP_054215100.1  zinc finger MIZ domain-containing protein 2 isoform X1

    16. XM_054359121.1 → XP_054215096.1  zinc finger MIZ domain-containing protein 2 isoform X1

    17. XM_054359135.1 → XP_054215110.1  zinc finger MIZ domain-containing protein 2 isoform X5

    18. XM_054359122.1 → XP_054215097.1  zinc finger MIZ domain-containing protein 2 isoform X1

    19. XM_054359129.1 → XP_054215104.1  zinc finger MIZ domain-containing protein 2 isoform X3

    20. XM_054359133.1 → XP_054215108.1  zinc finger MIZ domain-containing protein 2 isoform X5

    21. XM_054359139.1 → XP_054215114.1  zinc finger MIZ domain-containing protein 2 isoform X6

      UniProtKB/TrEMBL
      E7EWM3

    22. XM_054359140.1 → XP_054215115.1  zinc finger MIZ domain-containing protein 2 isoform X7

    23. XM_054359141.1 → XP_054215116.1  zinc finger MIZ domain-containing protein 2 isoform X8

    24. XM_054359143.1 → XP_054215118.1  zinc finger MIZ domain-containing protein 2 isoform X9

    25. XM_054359144.1 → XP_054215119.1  zinc finger MIZ domain-containing protein 2 isoform X10

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NF64.2 GenPept UniProtKB/Swiss-Prot:Q8NF64

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