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    Adgrf1 adhesion G protein-coupled receptor F1 [ Mus musculus (house mouse) ]

    Gene ID: 77596, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Adgrf1provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor F1provided by MGI
    Primary source
    MGI:MGI:1924846
    See related
    Ensembl:ENSMUSG00000041293 AllianceGenome:MGI:1924846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpr110; KPG_009; 5031409J19Rik
    Summary
    Enables G protein-coupled receptor activity. Acts upstream of or within several processes, including memory; nervous system development; and positive regulation of CREB transcription factor activity. Located in plasma membrane. Is expressed in adrenal gland; liver; and metanephros. Orthologous to human ADGRF1 (adhesion G protein-coupled receptor F1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 3.1), liver adult (RPKM 1.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrf1 in Genome Data Viewer
    Location:
    17 B3; 17 19.71 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (43581174..43636767)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (43270283..43325876)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130008D07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:43369751-43370032 Neighboring gene predicted gene, 54007 Neighboring gene STARR-positive B cell enhancer mm9_chr17:43402088-43402388 Neighboring gene STARR-seq mESC enhancer starr_42590 Neighboring gene adhesion G protein-coupled receptor F5 Neighboring gene predicted gene, 25135 Neighboring gene STARR-seq mESC enhancer starr_42593 Neighboring gene STARR-seq mESC enhancer starr_42594 Neighboring gene meprin 1 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation. Banerjee S, et al. J Neuroinflammation, 2023 Aug 14. PMID 37580715, Free PMC Article
    2. Interaction between GPR110 (ADGRF1) and tight junction protein occludin implicated in blood-brain barrier permeability. Huang BX, et al. iScience, 2023 Apr 21. PMID 37123219, Free PMC Article
    3. Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury. Kwon HS, et al. Int J Mol Sci, 2023 Mar 10. PMID 36982411, Free PMC Article
    4. Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis. Zhang M, et al. Br J Nutr, 2023 Nov 28. PMID 36946032
    5. GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice. Chen H, et al. J Neuroinflammation, 2021 Jul 17. PMID 34273979, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
      Title: Comparative transcriptomic analysis of mammary gland tissues reveals the critical role of GPR110 in palmitic acid-stimulated milk protein and fat synthesis.
    2. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
      Title: Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1).
    3. Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
      Title: Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation.
    4. Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
      Title: Ligand-Induced Activation of GPR110 (ADGRF1) to Improve Visual Function Impaired by Optic Nerve Injury.
    5. GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
      Title: GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in mice.
    6. Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
      Title: Ligand-Induced GPR110 Activation Facilitates Axon Growth after Injury.
    7. Study demonstrated orphan G-protein coupled receptor 110 (GPR110, ADGRF1) as the synaptamide receptor, mediating synaptamide-induced bioactivity in a cAMP-dependent manner.
      Title: Orphan GPR110 (ADGRF1) targeted by N-docosahexaenoylethanolamine in development of neurons and cognitive function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in energy reserve metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fat cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron projection development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor F1
    Names
    G protein coupled receptor Gpr110
    G-protein coupled receptor 110
    internal gene name of KIRIN laboratory:M5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133776.3 → NP_598537.2  adhesion G-protein coupled receptor F1 precursor

      See identical proteins and their annotated locations for NP_598537.2

      Status: VALIDATED

      Source sequence(s)
      CT025700
      Consensus CDS
      CCDS28795.1
      UniProtKB/Swiss-Prot
      B0V2Q5, Q8BMV8, Q8VEC3
      Related
      ENSMUSP00000049380.6, ENSMUST00000047399.6
      Conserved Domains (4) summary
      smart00303
      Location:530 → 571
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:584 → 607
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01390
      Location:153 → 240
      SEA; SEA domain
      cl28897
      Location:584 → 847
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      43581174..43636767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525120.4 → XP_006525183.1  adhesion G-protein coupled receptor F1 isoform X1

      Conserved Domains (4) summary
      smart00303
      Location:549 → 590
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:603 → 626
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01390
      Location:172 → 258
      SEA; SEA domain
      cl28897
      Location:603 → 866
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_006525121.4 → XP_006525184.1  adhesion G-protein coupled receptor F1 isoform X2

      Conserved Domains (4) summary
      smart00303
      Location:548 → 589
      GPS; G-protein-coupled receptor proteolytic site domain
      cd14964
      Location:602 → 625
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01390
      Location:171 → 257
      SEA; SEA domain
      cl28897
      Location:602 → 865
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_876591.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEC3.2 GenPept UniProtKB/Swiss-Prot:Q8VEC3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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