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    Exoc1 exocyst complex component 1 [ Mus musculus (house mouse) ]

    Gene ID: 69940, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Exoc1provided by MGI
    Official Full Name
    exocyst complex component 1provided by MGI
    Primary source
    MGI:MGI:2445020
    See related
    Ensembl:ENSMUSG00000036435 AllianceGenome:MGI:2445020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SEC3; Sec3p; Sec3l1; 2810407P21Rik; A730011E05Rik
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Acts upstream of or within embryo implantation. Predicted to be located in cytoplasm. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Is expressed in fronto-nasal process mesenchyme; mandibular process mesenchyme; and maxillary process mesenchyme. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 16.5), CNS E14 (RPKM 14.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exoc1 in Genome Data Viewer
    Location:
    5 C3.3; 5 41.28 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (76677147..76718134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (76529307..76570298)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13446 Neighboring gene STARR-seq mESC enhancer starr_13447 Neighboring gene predicted gene, 34175 Neighboring gene neuromedin U Neighboring gene exocyst complex component 1 like Neighboring gene STARR-positive B cell enhancer ABC_E1053 Neighboring gene centrosomal protein 135 Neighboring gene capping protein inhibiting regulator of actin Neighboring gene predicted gene, 57768 Neighboring gene ribosomal protein L23a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes. Ogonuki N, et al. EMBO Rep, 2022 Jul 5. PMID 35587095, Free PMC Article
    2. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. Osawa Y, et al. Elife, 2021 May 11. PMID 33973520, Free PMC Article
    3. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation. Mizuno S, et al. Sci Rep, 2015 Sep 8. PMID 26346620, Free PMC Article
    4. Fibroproliferative response to urothelial failure obliterates the ureter lumen in a mouse model of prenatal congenital obstructive nephropathy. Lee AJ, et al. Sci Rep, 2016 Aug 11. PMID 27511831, Free PMC Article
    5. An Alternative Splicing Program for Mouse Craniofacial Development. Hooper JE, et al. Front Physiol, 2020. PMID 33013468, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.
      Title: EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice.
    2. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation
      Title: Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within embryo implantation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 1
    Names
    SEC3-like 1
    exocyst complex component Sec3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289770.2 → NP_001276699.1  exocyst complex component 1 isoform 2

      See identical proteins and their annotated locations for NP_001276699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons and contains another alternate in-frame exon compared to variant 4. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Consensus CDS
      CCDS71607.1
      UniProtKB/Swiss-Prot
      E9QQ24, Q8R3S6
      Related
      ENSMUSP00000084373.5, ENSMUST00000087133.11
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184 → 871
      Sec3_C; Exocyst complex component Sec3

    2. NM_001289771.2 → NP_001276700.1  exocyst complex component 1 isoform 3

      See identical proteins and their annotated locations for NP_001276700.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Consensus CDS
      CCDS71608.1
      UniProtKB/TrEMBL
      Q5PPR2
      Related
      ENSMUSP00000046719.7, ENSMUST00000049469.13
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184 → 856
      Sec3_C; Exocyst complex component Sec3

    3. NM_001359370.2 → NP_001346299.1  exocyst complex component 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (4).
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 881
      Sec3_C; Exocyst complex component Sec3

    4. NM_001359372.2 → NP_001346301.1  exocyst complex component 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 863
      Sec3_C; Exocyst complex component Sec3

    5. NM_001359373.1 → NP_001346302.1  exocyst complex component 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and coding sequence compared to variant 4. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 4.
      Source sequence(s)
      AC127332, AK042620
      Related
      ENSMUST00000137018.8
      Conserved Domains (1) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1

    6. NM_001401325.1 → NP_001388254.1  exocyst complex component 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC127332

    7. NM_001401326.1 → NP_001388255.1  exocyst complex component 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC127332

    8. NM_027270.3 → NP_081546.1  exocyst complex component 1 isoform 1

      See identical proteins and their annotated locations for NP_081546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and contains another alternate in-frame exon compared to variant 4. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 4.
      Source sequence(s)
      AC127332
      Consensus CDS
      CCDS39117.1
      UniProtKB/TrEMBL
      Q6P1Y9
      Related
      ENSMUSP00000109121.2, ENSMUST00000113493.8
      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 878
      Sec3_C; Exocyst complex component Sec3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      76677147..76718134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165480.1 → XP_036021373.1  exocyst complex component 1 isoform X3

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:184 → 889
      Sec3_C; Exocyst complex component Sec3

    2. XM_036165478.1 → XP_036021371.1  exocyst complex component 1 isoform X1

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195 → 900
      Sec3_C; Exocyst complex component Sec3

    3. XM_036165481.1 → XP_036021374.1  exocyst complex component 1 isoform X4

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195 → 885
      Sec3_C; Exocyst complex component Sec3

    4. XM_036165479.1 → XP_036021372.1  exocyst complex component 1 isoform X2

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:191 → 896
      Sec3_C; Exocyst complex component Sec3

    5. XM_036165484.1 → XP_036021377.1  exocyst complex component 1 isoform X7

      Conserved Domains (1) summary
      cl19950
      Location:25 → 512
      Sec3_C; Exocyst complex component Sec3

    6. XM_036165485.1 → XP_036021378.1  exocyst complex component 1 isoform X7

      Conserved Domains (1) summary
      cl19950
      Location:25 → 512
      Sec3_C; Exocyst complex component Sec3

    7. XM_036165482.1 → XP_036021375.1  exocyst complex component 1 isoform X5

      Conserved Domains (2) summary
      cd14683
      Location:3 → 120
      PH-EXOC1; PH-like domain of Exocyst complex component 1
      pfam09763
      Location:195 → 882
      Sec3_C; Exocyst complex component Sec3

    8. XM_036165486.1 → XP_036021379.1  exocyst complex component 1 isoform X8

      Conserved Domains (1) summary
      cl19950
      Location:6 → 494
      Sec3_C; Exocyst complex component Sec3

    9. XM_036165487.1 → XP_036021380.1  exocyst complex component 1 isoform X9

      Conserved Domains (1) summary
      cl19950
      Location:6 → 479
      Sec3_C; Exocyst complex component Sec3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3S6.4 GenPept UniProtKB/Swiss-Prot:Q8R3S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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