Fst follistatin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fstprovided by MGI
Official Full Name: follistatinprovided by MGI
Primary source: MGI:MGI:95586
See related: Ensembl:ENSMUSG00000021765 AllianceGenome:MGI:95586
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FS
Summary: The protein encoded by this gene binds to and negatively regulates activin, as well as other members of the transforming growth factor beta family, and acts to prevent uncontrolled cellular proliferation. This protein also contains a heparin-binding sequence. It is expressed in many of the tissues in which activin is synthesized and is thought to clear activin from the circulation by attachment to the cell surface. Alternative splicing results in multiple transcript variants that encode multiple protein isoforms, including FST315 and FST288, that differ at their C-terminus. Another isoform, FST303 is thought to be produced by proteolytic cleavage of FST315. These isoforms differ in their localization and in their ability to bind heparin. While FST315 is a circulating protein, FST288 is tissue-bound, and FST303 is gonad-specific. While deletion of all isoforms results in embryonic lethality, expression of just FST288 is sufficient for embryonic development, but the resultant mice have fertility defects. [provided by RefSeq, Aug 2014]
Expression: Biased expression in ovary adult (RPKM 18.5), limb E14.5 (RPKM 6.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 64.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (114588798..114595522, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (114452262..114458989, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance.
Title: Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance.
Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals.
Title: Follistatin regulates the specification of the apical cochlea responsible for low-frequency hearing in mammals.
Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice.
Title: Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice.
Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice.
Title: Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice.
miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin.
Title: miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin.
The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
Title: The caveolin-1 regulated protein follistatin protects against diabetic kidney disease.
These results support a model in which an imbalance of activin A and BMP4 signaling underpins the degeneration of postnatal thymic epithelial cell (TEC) maintenance during aging, and its reversal enables the transient replenishment of mature TECs.
Title: Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging.
our data support a novel role for the antifibrotic protein FST as an ROS scavenger with protective effects both in vitro and in vivo in CKD
Title: Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease.
Activin A and its antagonist follistatin as key regulators of hair cell differentiation.
Title: A counter gradient of Activin A and follistatin instructs the timing of hair cell differentiation in the murine cochlea.
this study identified Sp1 as the critical transcription factor regulating activation of the FST promoter in cav-1 KO MC through binding to a region within 123 bp of the transcription start site.
Title: Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Fst (e-PCR), detects polymorphism
- UniSTS:464673

Fst (e-PCR), detects polymorphism
- UniSTS:143144

Fst (e-PCR), detects polymorphism
- UniSTS:480345

NoName (e-PCR)
- UniSTS:491233

Fst (e-PCR), detects polymorphism
- UniSTS:257003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info
enables activin binding	IEA Inferred from Electronic Annotation more info
enables activin binding	ISO Inferred from Sequence Orthology more info
enables activin receptor antagonist activity	IEA Inferred from Electronic Annotation more info
enables activin receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IEA Inferred from Electronic Annotation more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of ameloblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of ameloblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamete generation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of hair follicle development	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: follistatin

Names: activin-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301373.1 → NP_001288302.1 follistatin isoform FST315 precursor

See identical proteins and their annotated locations for NP_001288302.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform, FST315 (PMID:17932109).

Source sequence(s)

AC110817, AK079916, AW987053, BC144926, BX514305, Z29532

Consensus CDS

CCDS88534.1

UniProtKB/Swiss-Prot

A6H6P0, P47931

Related

ENSMUSP00000022287.7, ENSMUST00000022287.8

Conserved Domains (3) summary

smart00274
Location:167 → 190

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors

pfam09289
Location:95 → 116

FOLN; Follistatin/Osteonectin-like EGF domain
NM_001301375.1 → NP_001288304.1 follistatin isoform FST288 precursor

See identical proteins and their annotated locations for NP_001288304.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes FST288 (PMID:20032047), which has a shorter C-terminus, compared to FST315.

Source sequence(s)

AC110817, AK079916, AK083556, AW987053, BC144926, BX514305, Z29532

Consensus CDS

CCDS88535.1

UniProtKB/TrEMBL

Q8BNY0

Related

ENSMUSP00000153365.2, ENSMUST00000223640.3

Conserved Domains (3) summary

smart00274
Location:167 → 190

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors

pfam09289
Location:95 → 116

FOLN; Follistatin/Osteonectin-like EGF domain
NM_008046.3 → NP_032072.1 follistatin isoform 2 precursor

See identical proteins and their annotated locations for NP_032072.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC110817, AK079916, AW987053, BC144926, BX514305, Z29532

Consensus CDS

CCDS36787.1

UniProtKB/Swiss-Prot

P47931

UniProtKB/TrEMBL

A0A0R4J026, Q8BNY0

Related

ENSMUSP00000156375.2, ENSMUST00000231252.2

Conserved Domains (3) summary

smart00274
Location:167 → 190

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors

pfam09289
Location:95 → 116

FOLN; Follistatin/Osteonectin-like EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

114588798..114595522 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247150.2 → XP_030103010.1 follistatin isoform X1

Conserved Domains (3) summary

smart00274
Location:167 → 190

FOLN; Follistatin-N-terminal domain-like

smart00280
Location:117 → 164

KAZAL; Kazal type serine protease inhibitors

pfam09289
Location:95 → 116

FOLN; Follistatin/Osteonectin-like EGF domain