U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Akna AT-hook transcription factor [ Mus musculus (house mouse) ]

    Gene ID: 100182, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Aknaprovided by MGI
    Official Full Name
    AT-hook transcription factorprovided by MGI
    Primary source
    MGI:MGI:2140340
    See related
    Ensembl:ENSMUSG00000039158 AllianceGenome:MGI:2140340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA binding activity. Involved in several processes, including epithelial to mesenchymal transition; neuroblast delamination; and neuroblast division in subventricular zone. Located in centriole; centrosome; and microtubule. Is expressed in genitourinary system; hemolymphoid system; nervous system; respiratory system; and sensory organ. Orthologous to human AKNA (AT-hook transcription factor). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in spleen adult (RPKM 37.5), thymus adult (RPKM 21.8) and 13 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Akna in Genome Data Viewer
    Location:
    4 B3; 4 33.96 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63285364..63328988, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63367123..63411094, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene orosomucoid 3 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor, opposite strand Neighboring gene predicted gene, 52742 Neighboring gene STARR-positive B cell enhancer ABC_E6185 Neighboring gene STARR-positive B cell enhancer ABC_E2692 Neighboring gene STARR-seq mESC enhancer starr_10437 Neighboring gene whirlin Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63141720-63141921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:63150850-63151053 Neighboring gene STARR-positive B cell enhancer mm9_chr4:63205604-63205905 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G1 Neighboring gene predicted gene, 38592

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Ma W, et al. Cell Res, 2011 Nov. PMID 21606955, Free PMC Article
    2. The centrosome protein AKNA regulates neurogenesis via microtubule organization. Camargo Ortega G, et al. Nature, 2019 Mar. PMID 30787442
    3. Genes expressed in Atoh1 neuronal lineages arising from the r1/isthmus rhombic lip. Machold R, et al. Gene Expr Patterns, 2011 Jun-Jul. PMID 21440680, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. targeted deletions of mouse AKNA, a hypothetical AT-hook-like transcription factor, sensitize mice to pathogen-induced inflammation and cause sudden neonatal death
      Title: Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC116630, mKIAA1968

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in delamination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial to mesenchymal transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial to mesenchymal transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuroblast delamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast delamination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuroblast division in subventricular zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast division in subventricular zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    microtubule organization protein AKNA
    Names
    AT-hook-containing transcription factor

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045514.4 → NP_001038979.1  microtubule organization protein AKNA isoform 1

      See identical proteins and their annotated locations for NP_001038979.1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      Consensus CDS
      CCDS38777.1
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
      Related
      ENSMUSP00000041614.5, ENSMUST00000035724.5
      Conserved Domains (1) summary
      pfam12443
      Location:584 → 681
      AKNA; AT-hook-containing transcription factor

    2. NM_001305432.2 → NP_001292361.1  microtubule organization protein AKNA isoform 1

      See identical proteins and their annotated locations for NP_001292361.1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      Consensus CDS
      CCDS38777.1
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114
      Conserved Domains (1) summary
      pfam12443
      Location:584 → 681
      AKNA; AT-hook-containing transcription factor

    3. NM_001426143.1 → NP_001413072.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    4. NM_001426144.1 → NP_001413073.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    5. NM_001426145.1 → NP_001413074.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    6. NM_001426146.1 → NP_001413075.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    7. NM_001426147.1 → NP_001413076.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    8. NM_001426148.1 → NP_001413077.1  microtubule organization protein AKNA isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL683828
      UniProtKB/Swiss-Prot
      Q3TC64, Q3TDM3, Q3U3N4, Q6ZPF9, Q80VW7, Q8CFV0, Q8R114

    9. NM_001426149.1 → NP_001413078.1  microtubule organization protein AKNA isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL683828

    10. NM_001426150.1 → NP_001413079.1  microtubule organization protein AKNA isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL683828

    11. NM_001426151.1 → NP_001413080.1  microtubule organization protein AKNA isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL683828

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63285364..63328988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163542.1 → XP_036019435.1  microtubule organization protein AKNA isoform X2

      Conserved Domains (1) summary
      pfam12443
      Location:584 → 681
      AKNA; AT-hook-containing transcription factor

    2. XM_036163544.1 → XP_036019437.1  microtubule organization protein AKNA isoform X3

      Conserved Domains (1) summary
      pfam12443
      Location:584 → 681
      AKNA; AT-hook-containing transcription factor

    3. XM_036163543.1 → XP_036019436.1  microtubule organization protein AKNA isoform X3

      Conserved Domains (1) summary
      pfam12443
      Location:584 → 681
      AKNA; AT-hook-containing transcription factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VW7.1 GenPept UniProtKB/Swiss-Prot:Q80VW7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools