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    Camk2d calcium/calmodulin-dependent protein kinase II, delta [ Mus musculus (house mouse) ]

    Gene ID: 108058, updated on 5-Nov-2024

    Summary

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    Official Symbol
    Camk2dprovided by MGI
    Official Full Name
    calcium/calmodulin-dependent protein kinase II, deltaprovided by MGI
    Primary source
    MGI:MGI:1341265
    See related
    Ensembl:ENSMUSG00000053819 AllianceGenome:MGI:1341265
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CaMK II; [d]-CaMKII; 2810011D23Rik; 8030469K03Rik
    Summary
    Enables calcium/calmodulin-dependent protein kinase activity and transmembrane transporter binding activity. Involved in regulation of relaxation of cardiac muscle. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; cardiac muscle contraction; and protein phosphorylation. Located in several cellular components, including T-tubule; axon initial segment; and intercalated disc. Is active in cochlear hair cell ribbon synapse and postsynaptic cytosol. Is expressed in several structures, including central nervous system; heart ventricle; olfactory epithelium; renal vasculature; and retina. Orthologous to human CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 17.7), adrenal adult (RPKM 15.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Camk2d in Genome Data Viewer
    Location:
    3 G1- G2; 3 55.97 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (126389136..126639975)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (126595487..126846326)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08932 Neighboring gene STARR-seq mESC enhancer starr_08933 Neighboring gene STARR-seq mESC enhancer starr_08934 Neighboring gene STARR-seq mESC enhancer starr_08935 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene predicted gene, 46823 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126278818-126279119 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:126299066-126299249 Neighboring gene STARR-positive B cell enhancer ABC_E7941 Neighboring gene STARR-positive B cell enhancer ABC_E9570 Neighboring gene STARR-positive B cell enhancer ABC_E8805 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126393622-126393923 Neighboring gene STARR-positive B cell enhancer ABC_E9571 Neighboring gene VISTA enhancer mm1653 Neighboring gene predicted gene 15551 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126454256-126454557 Neighboring gene STARR-positive B cell enhancer ABC_E11215 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126474504-126474805 Neighboring gene STARR-positive B cell enhancer ABC_E11216 Neighboring gene STARR-seq mESC enhancer starr_08938 Neighboring gene STARR-seq mESC enhancer starr_08939 Neighboring gene STARR-positive B cell enhancer mm9_chr3:126606343-126606644 Neighboring gene STARR-seq mESC enhancer starr_08940 Neighboring gene STARR-seq mESC enhancer starr_08941 Neighboring gene ankyrin 2, brain Neighboring gene predicted gene, 25501 Neighboring gene STARR-seq mESC enhancer starr_08943 Neighboring gene predicted gene, 16958

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII. Morotti S, et al. J Physiol, 2014 Mar 15. PMID 24421356, Free PMC Article
    2. The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. Zhang T, et al. J Biol Chem, 2002 Jan 11. PMID 11694533
    3. CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway. Lu DZ, et al. Mol Cell Endocrinol, 2020 May 15. PMID 32173349
    4. Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts. Mohamed BA, et al. Sci Rep, 2019 Jul 8. PMID 31285482, Free PMC Article
    5. Axonal localization of delta Ca2+/calmodulin-dependent protein kinase II in developing P19 neurons. Faison MO, et al. Int J Dev Neurosci, 2002 Dec. PMID 12526889

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CaMKIIdelta, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP.
      Title: CaMKIIδ, Stabilized by RNA N6-Methyladenosine Reader IGF2BP2, Boosts Coxsackievirus B3-Induced Myocardial Inflammation via Interacting with TIRAP.
    2. [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKgamma and CaMKdelta against ischemic reperfusion injury in mice].
      Title: [PI3K/Akt/Erk signaling pathway mediates neuroprotection of CaMKⅡγ and CaMKⅡδ against ischemic reperfusion injury in mice].
    3. Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2delta.
      Title: Using CRISPR-Cas9/phosphoproteomics to identify substrates of calcium/calmodulin-dependent kinase 2δ.
    4. Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling.
      Title: Researches of calcium-activated chloride channel ANO1 intervening amyotrophic lateral sclerosis progression by activating EGFR and CaMKII signaling.
    5. Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain.
      Title: Oxidative stress-induced autonomous activation of the calcium/calmodulin-dependent kinase II involves disulfide formation in the regulatory domain.
    6. Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
      Title: Adipocyte CAMK2 deficiency improves obesity-associated glucose intolerance.
    7. Hyperglycemia regulates cardiac K(+) channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
      Title: Hyperglycemia regulates cardiac K(+) channels via O-GlcNAc-CaMKII and NOX2-ROS-PKC pathways.
    8. CaMKII exacerbates heart failure progression by activating class I HDACs.
      Title: CaMKII exacerbates heart failure progression by activating class I HDACs.
    9. CaMKII(delta) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
      Title: CaMKII(δ) regulates osteoclastogenesis through ERK, JNK, and p38 MAPKs and CREB signalling pathway.
    10. CaM Kinase II-delta Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
      Title: CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
    Submit: New GeneRIF Correction See all GeneRIFs (62)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4163, MGC60852, mKIAA4163

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium/calmodulin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nitric-oxide synthase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables titin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cardiac muscle cell contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular potassium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Rac protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cardiac muscle hypertrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein autophosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of relaxation of cardiac muscle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in relaxation of cardiac muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in T-tubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of calcium- and calmodulin-dependent protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cochlear hair cell ribbon synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sarcoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    calcium/calmodulin-dependent protein kinase type II subunit delta
    Names
    caM kinase II subunit delta
    caMK-II subunit delta
    NP_001020609.1
    NP_001020610.1
    NP_001280592.1
    NP_001280593.1
    NP_001280594.1
    NP_001280595.1
    NP_001333564.1
    NP_001333565.1
    NP_076302.1
    XP_006500881.1
    XP_006500882.1
    XP_006500883.1
    XP_006500885.1
    XP_006500886.1
    XP_006500887.1
    XP_006500888.1
    XP_006500889.1
    XP_006500892.1
    XP_006500896.1
    XP_006500897.1
    XP_006500898.1
    XP_006500899.1
    XP_006500902.1
    XP_017174904.1
    XP_017174905.1
    XP_017174906.1
    XP_017174907.1
    XP_017174908.1
    XP_017174909.1
    XP_017174911.1
    XP_030108200.1
    XP_030108201.1
    XP_030108202.1
    XP_030108203.1
    XP_030108204.1
    XP_030108205.1
    XP_030108206.1
    XP_036018696.1
    XP_036018697.1
    XP_036018698.1
    XP_036018699.1
    XP_036018700.1
    XP_036018701.1
    XP_036018702.1
    XP_036018703.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025438.2 → NP_001020609.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2

      See identical proteins and their annotated locations for NP_001020609.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, and has multiple differences in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter compared to isoform 1.
      Source sequence(s)
      AC102591, AC110174, BP761508
      Consensus CDS
      CCDS17823.1
      UniProtKB/Swiss-Prot
      Q3UF87, Q3UQH9, Q5DTK4, Q6PHZ2, Q8CAC5, Q9CZE2
      Related
      ENSMUSP00000143504.2, ENSMUST00000199300.5
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346 → 473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    2. NM_001025439.2 → NP_001020610.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 1

      See identical proteins and their annotated locations for NP_001020610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      AC102591, AC110174, AK039076, BP761508
      Consensus CDS
      CCDS38624.1
      UniProtKB/TrEMBL
      E9Q1W0
      Related
      ENSMUSP00000102007.3, ENSMUST00000106399.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:380 → 507
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    3. NM_001293663.1 → NP_001280592.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 4

      See identical proteins and their annotated locations for NP_001280592.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon and contains an alternate exon but maintains the reading frame compared to variant 1. The encoded isoform (4) is the same length as isoform 1, but contains a distinct internal segment.
      Source sequence(s)
      AC102591, AC110174, BP761508
      Consensus CDS
      CCDS80015.1
      UniProtKB/Swiss-Prot
      Q6PHZ2
      Related
      ENSMUSP00000102010.2, ENSMUST00000106402.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:380 → 507
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    4. NM_001293664.1 → NP_001280593.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 5

      See identical proteins and their annotated locations for NP_001280593.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate exons and contains one alternate exon, but maintains the reading frame compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AC102591, AC110174, AK148840, BP761508
      Consensus CDS
      CCDS80016.1
      UniProtKB/Swiss-Prot
      Q6PHZ2
      Related
      ENSMUSP00000063359.8, ENSMUST00000066466.13
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:360 → 487
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    5. NM_001293665.1 → NP_001280594.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. These differences result in a different 5' UTR, cause translation initiation at an alternate start codon and result in a frameshift compared to variant 1. The encoded isoform (6) has distinct N- and C- termini, and is shorter compared to isoform 1.
      Source sequence(s)
      AC102591, AC110174, BC057103, BP761508
      Conserved Domains (2) summary
      pfam08332
      Location:214 → 341
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:6 → 171
      PKc_like; Protein Kinases, catalytic domain

    6. NM_001293666.1 → NP_001280595.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 7

      See identical proteins and their annotated locations for NP_001280595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks several alternate exons, and contains two alternate exons, resulting in a novel 3' coding region compared to variant 1. The encoded isoform (7) is shorter, and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC102591, AC110174, AK032524, BM899824
      Consensus CDS
      CCDS80017.1
      UniProtKB/TrEMBL
      Q8CCM0
      Related
      ENSMUSP00000133019.2, ENSMUST00000163226.8
      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    7. NM_001346635.1 → NP_001333564.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC102591, AC110174
      Consensus CDS
      CCDS84670.1
      UniProtKB/TrEMBL
      A0A0G2JGS4
      Related
      ENSMUSP00000143677.2, ENSMUST00000200171.5
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:380 → 507
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    8. NM_001346636.1 → NP_001333565.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC102591, AC110174
      Consensus CDS
      CCDS84671.1
      UniProtKB/TrEMBL
      E9Q1T1
      Related
      ENSMUSP00000129999.2, ENSMUST00000171289.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:380 → 507
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    9. NM_023813.4 → NP_076302.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform 3

      See identical proteins and their annotated locations for NP_076302.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC102591, AC110174, AK012702, BP761508
      Consensus CDS
      CCDS51065.1
      UniProtKB/Swiss-Prot
      Q6PHZ2
      Related
      ENSMUSP00000102008.3, ENSMUST00000106400.9
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346 → 473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      126389136..126639975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252342.1 → XP_030108202.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X20

      Conserved Domains (2) summary
      pfam08332
      Location:251 → 378
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain

    2. XM_030252344.1 → XP_030108204.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X25

      Conserved Domains (2) summary
      pfam08332
      Location:251 → 378
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain

    3. XM_030252343.1 → XP_030108203.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X24

      Conserved Domains (2) summary
      pfam08332
      Location:231 → 358
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain

    4. XM_030252346.1 → XP_030108206.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X30

      Conserved Domains (2) summary
      pfam08332
      Location:231 → 358
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain

    5. XM_006500823.4 → XP_006500886.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X10

      See identical proteins and their annotated locations for XP_006500886.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357 → 484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    6. XM_006500829.4 → XP_006500892.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X17

      Related
      ENSMUSP00000102009.3, ENSMUST00000106401.8
      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357 → 484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    7. XM_006500819.4 → XP_006500882.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3

      See identical proteins and their annotated locations for XP_006500882.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:366 → 493
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    8. XM_006500825.4 → XP_006500888.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X14

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:366 → 493
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    9. XM_006500820.4 → XP_006500883.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X5

      See identical proteins and their annotated locations for XP_006500883.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:360 → 487
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    10. XM_006500824.4 → XP_006500887.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X12

      See identical proteins and their annotated locations for XP_006500887.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:356 → 483
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    11. XM_006500818.4 → XP_006500881.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1

      See identical proteins and their annotated locations for XP_006500881.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:379 → 506
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    12. XM_017319419.2 → XP_017174908.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:379 → 506
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    13. XM_017319416.2 → XP_017174905.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:365 → 492
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    14. XM_006500822.4 → XP_006500885.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X7

      See identical proteins and their annotated locations for XP_006500885.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:359 → 486
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    15. XM_030252340.1 → XP_030108200.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X16

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:359 → 486
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    16. XM_006500826.4 → XP_006500889.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X15

      See identical proteins and their annotated locations for XP_006500889.1

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:345 → 472
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    17. XM_017319420.2 → XP_017174909.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X11

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:357 → 484
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    18. XM_017319417.2 → XP_017174906.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X6

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:360 → 487
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    19. XM_036162803.1 → XP_036018696.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X13

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346 → 473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    20. XM_036162804.1 → XP_036018697.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X18

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:346 → 473
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    21. XM_017319415.2 → XP_017174904.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:379 → 506
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    22. XM_017319418.2 → XP_017174907.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:359 → 486
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    23. XM_017319422.2 → XP_017174911.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X36

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:366 → 493
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    24. XM_030252341.1 → XP_030108201.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X19

      Conserved Domains (2) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
      pfam08332
      Location:345 → 472
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

    25. XM_006500834.5 → XP_006500897.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X23

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    26. XM_006500833.4 → XP_006500896.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X22

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    27. XM_006500835.4 → XP_006500898.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X26

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    28. XM_030252345.1 → XP_030108205.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X28

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    29. XM_006500839.5 → XP_006500902.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X32

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    30. XM_036162809.1 → XP_036018702.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X34

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    31. XM_036162808.1 → XP_036018701.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X33

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    32. XM_036162807.1 → XP_036018700.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X31

      Conserved Domains (1) summary
      cd14086
      Location:12 → 303
      STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

    33. XM_036162805.1 → XP_036018698.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X21

      Conserved Domains (2) summary
      pfam08332
      Location:248 → 375
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:6 → 171
      PKc_like; Protein Kinases, catalytic domain

    34. XM_036162806.1 → XP_036018699.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X29

      Conserved Domains (2) summary
      pfam08332
      Location:214 → 341
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:6 → 171
      PKc_like; Protein Kinases, catalytic domain

    35. XM_036162810.1 → XP_036018703.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X35

      Conserved Domains (2) summary
      pfam08332
      Location:214 → 341
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:6 → 171
      PKc_like; Protein Kinases, catalytic domain

    36. XM_006500836.4 → XP_006500899.1  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X27

      Conserved Domains (2) summary
      pfam08332
      Location:217 → 344
      CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
      cl21453
      Location:1 → 174
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHZ2.1 GenPept UniProtKB/Swiss-Prot:Q6PHZ2

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