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    Cysltr1 cysteinyl leukotriene receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 58861, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cysltr1provided by MGI
    Official Full Name
    cysteinyl leukotriene receptor 1provided by MGI
    Primary source
    MGI:MGI:1926218
    See related
    Ensembl:ENSMUSG00000052821 AllianceGenome:MGI:1926218
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cyslt1; CysLT1R
    Summary
    Enables leukotriene receptor activity. Acts upstream of or within several processes, including calcium ion transport; chemotaxis; and inflammatory response to antigenic stimulus. Located in plasma membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in allergic disease; asthma; and rhinitis. Orthologous to human CYSLTR1 (cysteinyl leukotriene receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 1.9), bladder adult (RPKM 1.0) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cysltr1 in Genome Data Viewer
    Location:
    X 47.36 cM; X D
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105617952..105647329, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106576509..106603679, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene fibronectin type III domain containing 3C1 pseudogene Neighboring gene fibronectin type III domain containing 3C1 Neighboring gene STARR-seq mESC enhancer starr_47737 Neighboring gene predicted gene, 24622 Neighboring gene predicted gene 5127 Neighboring gene predicted gene 14877 Neighboring gene STARR-seq mESC enhancer starr_47738 Neighboring gene zinc finger protein 277 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model. Mosala P, et al. Front Immunol, 2024. PMID 38840916, Free PMC Article
    2. Leukotriene D4 induces cognitive impairment through enhancement of CysLT₁ R-mediated amyloid-β generation in mice. Tang SS, et al. Neuropharmacology, 2013 Feb. PMID 22982445
    3. Identification of a murine cysteinyl leukotriene receptor by expression in Xenopus laevis oocytes. Mollerup J, et al. Biochim Biophys Acta, 2001 Feb 16. PMID 11342226
    4. Modulation of leukotriene D4 attenuates the development of seizures in mice. Rehni AK, et al. Prostaglandins Leukot Essent Fatty Acids, 2011 Aug. PMID 21641195
    5. Double mutation at the putative protein kinase C phosphorylation sites Thr151 plus Thr323 in the mouse leukotrieneD4 receptor eliminates homologous desensitization. Jørgensen ST, et al. Cell Physiol Biochem, 2013. PMID 23485744

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model.
      Title: Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model.
    2. Deficiency of astrocyte CysLT1R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission.
      Title: Deficiency of astrocyte CysLT(1)R ameliorates depression-like behaviors in mice by modulating glutamate synaptic transmission.
    3. Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
      Title: Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption.
    4. RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
      Title: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
    5. Montelukast attenuates interleukin IL-1beta-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2).
      Title: Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2).
    6. Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma.
      Title: Cysteinyl leukotriene induces eosinophil extracellular trap formation via cysteinyl leukotriene 1 receptor in a murine model of asthma.
    7. these findings highlight the essential role of cysLT1R in suppressing pancreatic insulin secretion, and potentially provided a new insight into understanding the mechanical regulation of glucose homeostasis.
      Title: Cysteinyl leukotriene receptor 1 regulates glucose-stimulated insulin secretion (GSIS).
    8. Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption.
      Title: Cysteinyl leukotriene receptor 1 (cysLT1R) regulates osteoclast differentiation and bone resorption.
    9. Montelukast also served a protective role in a murine ovariectomy (OVX) and unloadinginduced bone loss model. Altogether, these results confirmed that the CysLTR1 antagonist exerted an inhibitory effect on OC formation in vitro and in vivo. It may be useful for the treatment of bone diseases associated with excessive bone resorption.
      Title: Montelukast inhibits RANKL‑induced osteoclast formation and bone loss via CysLTR1 and P2Y12.
    10. The study presents a genetic approach in a colitis-associated colon cancer model further supporting an important role for CysLT1R signaling in colon tumorigenesis, driving immune mediators to promote immune cell infiltration in tumors.
      Title: Cysteinyl leukotriene receptor 1 facilitates tumorigenesis in a mouse model of colitis-associated colon cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteinyl leukotriene receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables leukotriene receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables leukotriene receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell surface receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in leukotriene signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of glial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteinyl leukotriene receptor 1
    Names
    LTD4 receptor
    cysteinyl leukotriene D4 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281859.1 → NP_001268788.1  cysteinyl leukotriene receptor 1 isoform a

      See identical proteins and their annotated locations for NP_001268788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK033476, AL732460
      Consensus CDS
      CCDS41098.1
      UniProtKB/Swiss-Prot
      Q544P1, Q99JA4, Q9JJ71, Q9JK47
      Related
      ENSMUSP00000063520.4, ENSMUST00000064892.4
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 310
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:47 → 264
      7tm_4; Olfactory receptor

    2. NM_001281862.1 → NP_001268791.1  cysteinyl leukotriene receptor 1 isoform b

      See identical proteins and their annotated locations for NP_001268791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AL732460
      UniProtKB/Swiss-Prot
      Q99JA4
      Conserved Domains (1) summary
      cd15158
      Location:26 → 308
      7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_021476.5 → NP_067451.2  cysteinyl leukotriene receptor 1 isoform a

      See identical proteins and their annotated locations for NP_067451.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK033476, AL732460
      Consensus CDS
      CCDS41098.1
      UniProtKB/Swiss-Prot
      Q544P1, Q99JA4, Q9JJ71, Q9JK47
      Related
      ENSMUSP00000109108.2, ENSMUST00000113480.2
      Conserved Domains (2) summary
      pfam00001
      Location:55 → 310
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:47 → 264
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      105617952..105647329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162055.1 → XP_036017948.1  cysteinyl leukotriene receptor 1 isoform X1

      Conserved Domains (1) summary
      cd15158
      Location:26 → 308
      7tmA_CysLTR1; cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99JA4.1 GenPept UniProtKB/Swiss-Prot:Q99JA4

    Gene LinkOut

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