Gzmn granzyme N [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gzmnprovided by MGI
Official Full Name: granzyme Nprovided by MGI
Primary source: MGI:MGI:2675494
See related: Ensembl:ENSMUSG00000015443 AllianceGenome:MGI:2675494
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GrN
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including granzyme-mediated programmed cell death signaling pathway; natural killer cell mediated cytotoxicity; and pyroptotic inflammatory response. Predicted to be located in cytolytic granule. Predicted to be active in cytoplasm and extracellular space. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human GZMB (granzyme B). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Restricted expression toward testis adult (RPKM 22.5) See more
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56403243..56412069, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56165786..56174612, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gzmn is not involved in the process of germ cell apoptosis induced by heat shock, but it may be involved in spermatogenesis in the mouse testes.
Title: Granzyme N, a novel granzyme, is expressed in spermatocytes and spermatids of the mouse testis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in granzyme-mediated programmed cell death signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyroptotic inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytolytic granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: granzyme N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305808.2 → NP_001292737.1 granzyme N isoform 1 precursor

See identical proteins and their annotated locations for NP_001292737.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).

Source sequence(s)

AC091783

Consensus CDS

CCDS88673.1

UniProtKB/TrEMBL

Q76HN3

Related

ENSMUSP00000153137.2, ENSMUST00000225535.2

Conserved Domains (2) summary

smart00020
Location:20 → 195

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 194

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_153052.3 → NP_694692.1 granzyme N isoform 2 precursor

See identical proteins and their annotated locations for NP_694692.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC091783

Consensus CDS

CCDS27145.1

UniProtKB/TrEMBL

Q920S1

Related

ENSMUSP00000015587.8, ENSMUST00000015587.9

Conserved Domains (2) summary

smart00020
Location:20 → 241

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 244

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

56403243..56412069 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519020.2 → XP_006519083.1 granzyme N isoform X1

Conserved Domains (1) summary

cd00190
Location:5 → 228

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_017316021.2 → XP_017171510.1 granzyme N isoform X3

Conserved Domains (1) summary

cd00190
Location:21 → 114

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_017316020.1 → XP_017171509.1 granzyme N isoform X2

Conserved Domains (1) summary

cd00190
Location:21 → 114

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...