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    Icos inducible T cell co-stimulator [ Mus musculus (house mouse) ]

    Gene ID: 54167, updated on 28-Oct-2024

    Summary

    Official Symbol
    Icosprovided by MGI
    Official Full Name
    inducible T cell co-stimulatorprovided by MGI
    Primary source
    MGI:MGI:1858745
    See related
    Ensembl:ENSMUSG00000026009 AllianceGenome:MGI:1858745
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H4; CCLP; AILIM; CRP-1; Ly115
    Summary
    Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Icos in Genome Data Viewer
    Location:
    1 C2; 1 30.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60999909..61039481)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60960773..61000322)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34649 Neighboring gene dynein light chain LC8-type 1 pseudogene Neighboring gene ribosomal protein L17, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_01081 Neighboring gene STARR-seq mESC enhancer starr_01082 Neighboring gene VISTA enhancer mm1601 Neighboring gene STARR-seq mESC enhancer starr_01083 Neighboring gene STARR-seq mESC enhancer starr_01084 Neighboring gene STARR-seq mESC enhancer starr_01085 Neighboring gene predicted gene 11587

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (10) 
    • Targeted (13)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell tolerance induction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell tolerance induction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    inducible T-cell costimulator
    Names
    CD28 and CTLA-4-like protein
    CD28-related protein 1
    activation-inducible lymphocyte immunomediatory molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017480.3NP_059508.2  inducible T-cell costimulator precursor

      See identical proteins and their annotated locations for NP_059508.2

      Status: VALIDATED

      Source sequence(s)
      AL645744
      Consensus CDS
      CCDS14994.1
      UniProtKB/Swiss-Prot
      Q9JL17, Q9WVS0
      UniProtKB/TrEMBL
      A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7
      Related
      ENSMUSP00000099891.4, ENSMUST00000102827.4
      Conserved Domains (1) summary
      pfam15910
      Location:23135
      V-set_2; ICOS V-set domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60999909..61039481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496138.3XP_006496201.1  inducible T-cell costimulator isoform X1

      See identical proteins and their annotated locations for XP_006496201.1

      UniProtKB/Swiss-Prot
      Q9JL17, Q9WVS0
      UniProtKB/TrEMBL
      A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7
      Conserved Domains (1) summary
      pfam15910
      Location:23135
      V-set_2; ICOS V-set domain
    2. XM_006496139.3XP_006496202.1  inducible T-cell costimulator isoform X1

      See identical proteins and their annotated locations for XP_006496202.1

      UniProtKB/Swiss-Prot
      Q9JL17, Q9WVS0
      UniProtKB/TrEMBL
      A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7
      Conserved Domains (1) summary
      pfam15910
      Location:23135
      V-set_2; ICOS V-set domain
    3. XM_006496140.1XP_006496203.1  inducible T-cell costimulator isoform X2

      UniProtKB/TrEMBL
      A2A6A7
      Conserved Domains (1) summary
      pfam15910
      Location:1106
      V-set_2; ICOS V-set domain