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    Fastkd2 FAST kinase domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 75619, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Fastkd2provided by MGI
    Official Full Name
    FAST kinase domains 2provided by MGI
    Primary source
    MGI:MGI:1922869
    See related
    Ensembl:ENSMUSG00000025962 AllianceGenome:MGI:1922869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810421I24Rik
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in several processes, including mitochondrial gene expression; mitochondrial large ribosomal subunit assembly; and post-transcriptional regulation of gene expression. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut; heart; and respiratory system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 44. Orthologous to human FASTKD2 (FAST kinase domains 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.3), CNS E11.5 (RPKM 5.2) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fastkd2 in Genome Data Viewer
    Location:
    1 C2; 1 32.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63769758..63792544)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63730599..63753385)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dystrotelin Neighboring gene STARR-seq mESC enhancer starr_01143 Neighboring gene malate dehydrogenase 1B, NAD (soluble) Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63777041-63777224 Neighboring gene RIKEN cDNA 4933402D24 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:63810015-63810202 Neighboring gene STARR-seq mESC enhancer starr_01145 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    2. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article
    3. The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes. Liu F, et al. Mol Cell Proteomics, 2018 Feb. PMID 29222160, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial large ribosomal subunit assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 2, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172422.3 → NP_766010.1  FAST kinase domain-containing protein 2, mitochondrial

      See identical proteins and their annotated locations for NP_766010.1

      Status: VALIDATED

      Source sequence(s)
      AK035322, AK084971, AK148224
      Consensus CDS
      CCDS15001.1
      UniProtKB/Swiss-Prot
      Q3TLQ2, Q3U526, Q3UFY6, Q8BT79, Q8C3T6, Q922E6
      UniProtKB/TrEMBL
      Q6ZQ14
      Related
      ENSMUSP00000027103.7, ENSMUST00000027103.7
      Conserved Domains (3) summary
      smart00952
      Location:619 → 675
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:443 → 512
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:561 → 596
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63769758..63792544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496313.2 → XP_006496376.2  FAST kinase domain-containing protein 2, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q6ZQ14
      Related
      ENSMUST00000128621.8
      Conserved Domains (3) summary
      smart00952
      Location:584 → 640
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:408 → 477
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:494 → 561
      FAST_2; FAST kinase-like protein, subdomain 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922E6.2 GenPept UniProtKB/Swiss-Prot:Q922E6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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