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    Zfp369 zinc finger protein 369 [ Mus musculus (house mouse) ]

    Gene ID: 170936, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp369provided by MGI
    Official Full Name
    zinc finger protein 369provided by MGI
    Primary source
    MGI:MGI:2176229
    See related
    Ensembl:ENSMUSG00000021514 AllianceGenome:MGI:2176229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NRIF2; B930030B22Rik; D230020H11Rik
    Summary
    Enables neurotrophin p75 receptor binding activity. Acts upstream of or within regulation of cell cycle. Located in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.4), thymus adult (RPKM 3.2) and 28 other tissues See more
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    Genomic context

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    See Zfp369 in Genome Data Viewer
    Location:
    13 B3; 13 34.47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (65411975..65452038)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (65277228..65304222)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36445 Neighboring gene STARR-seq mESC enhancer starr_34838 Neighboring gene STARR-seq mESC enhancer starr_34839 Neighboring gene predicted gene 10775 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 53789 Neighboring gene predicted gene 7762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Strain-specific complementation between NRIF1 and NRIF2, two zinc finger proteins sharing structural and biochemical properties. Benzel I, et al. Gene, 2001 Dec 27. PMID 11750124
    2. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Marshall KE, et al. Genome Biol, 2002. PMID 12537567, Free PMC Article
    3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotrophin p75 receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurotrophin receptor-interacting factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178364.5 → NP_848141.3  neurotrophin receptor-interacting factor 2

      See identical proteins and their annotated locations for NP_848141.3

      Status: VALIDATED

      Source sequence(s)
      AC154552
      Consensus CDS
      CCDS26605.2
      UniProtKB/Swiss-Prot
      Q8BJF0, Q8K1Y8, Q921B4
      UniProtKB/TrEMBL
      F8VQL6
      Related
      ENSMUSP00000119114.2, ENSMUST00000126879.8
      Conserved Domains (8) summary
      smart00349
      Location:35 → 94
      KRAB; krueppel associated box
      COG5048
      Location:727 → 792
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:759 → 779
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:676 → 695
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:785 → 807
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:300 → 339
      KRAB; KRAB box
      pfam02023
      Location:179 → 266
      SCAN; SCAN domain
      pfam13465
      Location:799 → 824
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      65411975..65452038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157881.1 → XP_036013774.1  neurotrophin receptor-interacting factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8BJF0, Q8K1Y8, Q921B4
      Conserved Domains (6) summary
      sd00017
      Location:706 → 726
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:623 → 642
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:732 → 754
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:246 → 287
      KRAB; KRAB box
      pfam02023
      Location:126 → 208
      SCAN; SCAN domain
      pfam13465
      Location:746 → 771
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011244491.3 → XP_011242793.1  neurotrophin receptor-interacting factor 2 isoform X2

      Conserved Domains (7) summary
      sd00017
      Location:696 → 716
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:613 → 632
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:722 → 744
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:236 → 277
      KRAB; KRAB box
      pfam02023
      Location:116 → 203
      SCAN; SCAN domain
      pfam13465
      Location:736 → 761
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_030247169.2 → XP_030103029.1  neurotrophin receptor-interacting factor 2 isoform X3

      Conserved Domains (6) summary
      sd00017
      Location:664 → 684
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:581 → 600
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:690 → 712
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:204 → 245
      KRAB; KRAB box
      pfam02023
      Location:84 → 171
      SCAN; SCAN domain
      pfam13465
      Location:704 → 729
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006517116.5 → XP_006517179.1  neurotrophin receptor-interacting factor 2 isoform X4

      Conserved Domains (2) summary
      smart00349
      Location:35 → 94
      KRAB; krueppel associated box
      pfam02023
      Location:179 → 266
      SCAN; SCAN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921B4.1 GenPept UniProtKB/Swiss-Prot:Q921B4

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