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    Myl6 myosin, light polypeptide 6, alkali, smooth muscle and non-muscle [ Mus musculus (house mouse) ]

    Gene ID: 17904, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Myl6provided by MGI
    Official Full Name
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscleprovided by MGI
    Primary source
    MGI:MGI:109318
    See related
    Ensembl:ENSMUSG00000090841 AllianceGenome:MGI:109318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LC17; Myln; ESMLC; MLC-3; MLC1SM; LC17-GI
    Summary
    Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Part of unconventional myosin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 2188.3), placenta adult (RPKM 580.4) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myl6 in Genome Data Viewer
    Location:
    10 D3; 10 76.75 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128326728..128329755, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128490859..128493886, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene microRNA 8105 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1816 Neighboring gene myosin, light polypeptide 6B Neighboring gene STARR-positive B cell enhancer ABC_E8378 Neighboring gene Riken cDNA A430046D13 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of nonmuscle myosin light chain 3 gene expression in response to exogenous MLC3nm mRNA. Hailstones D, et al. Cell Mol Biol Res, 1994. PMID 7804326
    2. Changing patterns of gene expression in developing mouse kidney, as probed by differential mRNA display combined with cDNA library screening. Rosenblum ND, et al. Kidney Int, 1997 Mar. PMID 9067931
    3. Spata6 is required for normal assembly of the sperm connecting piece and tight head-tail conjunction. Yuan S, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605924, Free PMC Article
    4. Expression of the dystrophin-related protein 2 (Drp2) transcript in the mouse. Dixon AK, et al. J Mol Biol, 1997 Jul 25. PMID 9245586
    5. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis. Kubalak SW, et al. J Biol Chem, 1994 Jun 17. PMID 8207020

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106465, MGC107135

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle filament sliding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of unconventional myosin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin light polypeptide 6
    Names
    17 kDa myosin light chain
    myosin light chain A3
    myosin light chain alkali 3
    myosin light chain, alkali, nonmuscle
    smooth muscle and nonmuscle myosin light chain alkali 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317217.2 → NP_001304146.1  myosin light polypeptide 6 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 6 both encode the same isoform (a).
      Source sequence(s)
      AC170752
      Consensus CDS
      CCDS88111.1
      UniProtKB/TrEMBL
      A0A1W2P6F6, A0A1W2P7Q9
      Related
      ENSMUSP00000151915.2, ENSMUST00000219236.2
      Conserved Domains (3) summary
      smart00054
      Location:11 → 39
      EFh; EF-hand, calcium binding motif
      cd00051
      Location:94 → 144
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:11 → 75
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001317218.2 → NP_001304147.1  myosin light polypeptide 6 isoform MLC3nm

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 3' coding region, resulting in a framehsift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3nm, also known as LC17A and LC17-nm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3nm and MLC3sm are the same length but differ in their C-termini.
      Source sequence(s)
      AC170752
      Consensus CDS
      CCDS88112.1
      UniProtKB/Swiss-Prot
      Q60605
      UniProtKB/TrEMBL
      A0A1W2P6F6
      Related
      ENSMUSP00000151693.2, ENSMUST00000218127.2
      Conserved Domains (1) summary
      PTZ00184
      Location:5 → 150
      PTZ00184; calmodulin; Provisional

    3. NM_001317219.2 → NP_001304148.1  myosin light polypeptide 6 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (b) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 4 and 11 both encode the same isoform (b).
      Source sequence(s)
      AC170752
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 115
      PTZ00184; calmodulin; Provisional

    4. NM_001317220.2 → NP_001304149.1  myosin light polypeptide 6 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs, translation initiation at a downstream start codon, and a frameshift, compared to variant 1. The encoded isoform (c) has a shorter N-terminus and a distinct C-terminus, compared to isoform a. Isoforms b and c are the same length but differ in their C-termini. Variants 5, 9, and 10 all encode the same isoform (c).
      Source sequence(s)
      AC170752
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 114
      PTZ00184; calmodulin; Provisional

    5. NM_001428663.1 → NP_001415592.1  myosin light polypeptide 6 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC170752
      UniProtKB/TrEMBL
      A0A1W2P7Q9

    6. NM_001428664.1 → NP_001415593.1  myosin light polypeptide 6 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC170752

    7. NM_001428665.1 → NP_001415594.1  myosin light polypeptide 6 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC170752
      UniProtKB/TrEMBL
      A0A1W2P6G5

    8. NM_001428667.1 → NP_001415596.1  myosin light polypeptide 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC170752

    9. NM_001428668.1 → NP_001415597.1  myosin light polypeptide 6 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC170752

    10. NM_001428672.1 → NP_001415601.1  myosin light polypeptide 6 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC170752

    11. NM_001428673.1 → NP_001415602.1  myosin light polypeptide 6 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC170752

    12. NM_001428675.1 → NP_001415604.1  myosin light polypeptide 6 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC170752

    13. NM_001428677.1 → NP_001415606.1  myosin light polypeptide 6 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 15, encodes isoform h.
      Source sequence(s)
      AC170752

    14. NM_001428678.1 → NP_001415607.1  myosin light polypeptide 6 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC170752

    15. NM_001428679.1 → NP_001415608.1  myosin light polypeptide 6 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC170752

    16. NM_001428680.1 → NP_001415609.1  myosin light polypeptide 6 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC170752

    17. NM_001428681.1 → NP_001415610.1  myosin light polypeptide 6 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC170752

    18. NM_010860.5 → NP_034990.1  myosin light polypeptide 6 isoform MLC3sm

      See identical proteins and their annotated locations for NP_034990.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, resulting in a frameshift and a novel 3' UTR, compared to variant 1. The encoded isoform (MLC3sm, also known as LC17B and LC17-sm) has a distinct C-terminus and is shorter than isoform a. Isoforms MLC3sm and MLC3nm are the same length but differ in their C-termini. Isoforms b and c are the same length but differ in their C-termini.
      Source sequence(s)
      AC170752
      Consensus CDS
      CCDS48728.1
      UniProtKB/TrEMBL
      A0A1W2P6F6, Q642K0
      Related
      ENSMUSP00000128803.2, ENSMUST00000164181.2
      Conserved Domains (1) summary
      PTZ00184
      Location:5 → 149
      PTZ00184; calmodulin; Provisional

    RNA

    1. NR_190456.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC170752

    2. NR_190457.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC170752

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128326728..128329755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155669.1 → XP_036011562.1  myosin light polypeptide 6 isoform X1

      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 114
      PTZ00184; calmodulin; Provisional

    2. XM_036155670.1 → XP_036011563.1  myosin light polypeptide 6 isoform X2

      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 115
      PTZ00184; calmodulin; Provisional

    3. XM_030244939.2 → XP_030100799.1  myosin light polypeptide 6 isoform X2

      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 115
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60605.3 GenPept UniProtKB/Swiss-Prot:Q60605

    Gene LinkOut

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