Klk6 kallikrein related-peptidase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk6provided by MGI
Official Full Name: kallikrein related-peptidase 6provided by MGI
Primary source: MGI:MGI:1343166
See related: Ensembl:ENSMUSG00000050063 AllianceGenome:MGI:1343166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BSP; MSP; Bssp; Klk29; Prss9; Prss18; neurosin
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in positive regulation of G protein-coupled receptor signaling pathway; protein maturation; and regulation of neuron projection development. Is active in cornified envelope. Is expressed in several structures, including brain. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; demyelinating disease; and multiple system atrophy. Orthologous to human KLK6 (kallikrein related peptidase 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 16.1), stomach adult (RPKM 3.3) and 2 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43473967..43481219)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43824438..43832027)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter.
Title: Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter.
KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
Title: KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating Cross-Talk between Tumor Cells and Macrophages.
Blocking Kallikrein 6 promotes developmental myelination.
Title: Blocking Kallikrein 6 promotes developmental myelination.
Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
Title: Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a-synuclein in mouse brain.
KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Title: KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Elimination of Klk6 in Spink5 KO mice (model for Netherton syndrome (NS) remarkably suppresses the expression of Tslp, a major itching-inducing factor and driver of allergic reactions during differentiation of epidermal keratinocytes. Study demonstrated for the first time that KLK6 is implicated in skin inflammation and may represent a novel druggable target for NS and other inflammatory conditions e.g. atopic dermatitis.
Title: A proinflammatory role of KLK6 protease in Netherton syndrome.
The data are exciting because they demonstrate that Klk6 can influence astrocyte plasticity through receptor-dependent mechanisms.
Title: Kallikrein-related peptidase 6 orchestrates astrocyte form and function through proteinase activated receptor-dependent mechanisms.
expression strongly induced in psoriasiform epidermis; crucial for development of imiquimod-induced psoriasiform dermatitis
Title: Kallikrein-related peptidase 6 promotes psoriasiform skin inflammation through a protease-activated receptor 2-independent mechanism.
Kallikrein 6 secreted by oligodendrocytes plays a critical role in the pathogenesis of experimental autoimmune encephalomyelitis.
Title: Kallikrein 6 secreted by oligodendrocytes regulates the progression of experimental autoimmune encephalomyelitis.
Data show that kallikrein 6 (KLK6) expression is induced in mouse and human skin during chronic glucocorticoid treatment.
Title: Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prss19 (e-PCR), detects polymorphism
- UniSTS:255290

AI849898 (e-PCR)
- UniSTS:179561

Klk6 (e-PCR), detects polymorphism
- UniSTS:547448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein-6

Names: brain serine protease; kallikrein 29; kallikrein 6; myelencephalon-specific protease; myofibril-bound protease; protease M; protease, serine, 18; protease, serine, 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164696.2 → NP_001158168.1 kallikrein-6 precursor

See identical proteins and their annotated locations for NP_001158168.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AC134858

Consensus CDS

CCDS21184.2

UniProtKB/TrEMBL

O88301, Q91Y82

Related

ENSMUSP00000103600.4, ENSMUST00000107966.10

Conserved Domains (1) summary

smart00020
Location:28 → 244

Tryp_SPc; Trypsin-like serine protease
NM_001164697.2 → NP_001158169.1 kallikrein-6 precursor

See identical proteins and their annotated locations for NP_001158169.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AC134858

Consensus CDS

CCDS21184.2

UniProtKB/TrEMBL

O88301, Q91Y82

Related

ENSMUSP00000103602.4, ENSMUST00000107968.10

Conserved Domains (1) summary

smart00020
Location:28 → 244

Tryp_SPc; Trypsin-like serine protease
NM_001164698.2 → NP_001158170.1 kallikrein-6 precursor

See identical proteins and their annotated locations for NP_001158170.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.

Source sequence(s)

AC134858

Consensus CDS

CCDS21184.2

UniProtKB/TrEMBL

O88301, Q91Y82

Conserved Domains (1) summary

smart00020
Location:28 → 244

Tryp_SPc; Trypsin-like serine protease
NM_001417156.1 → NP_001404085.1 kallikrein-6 precursor

Status: VALIDATED

Source sequence(s)

AC134858

UniProtKB/TrEMBL

Q91Y82
NM_011177.3 → NP_035307.2 kallikrein-6 precursor

See identical proteins and their annotated locations for NP_035307.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.

Source sequence(s)

AC134858

Consensus CDS

CCDS21184.2

UniProtKB/TrEMBL

O88301, Q91Y82

Related

ENSMUSP00000103601.2, ENSMUST00000107967.3

Conserved Domains (1) summary

smart00020
Location:28 → 244

Tryp_SPc; Trypsin-like serine protease