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    Rfc2 replication factor C (activator 1) 2 [ Mus musculus (house mouse) ]

    Gene ID: 19718, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rfc2provided by MGI
    Official Full Name
    replication factor C (activator 1) 2provided by MGI
    Primary source
    MGI:MGI:1341868
    See related
    Ensembl:ENSMUSG00000023104 AllianceGenome:MGI:1341868
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    40kDa; Recc2; 2610008M13Rik
    Summary
    Enables enzyme binding activity. Predicted to be involved in DNA repair; DNA-templated DNA replication; and positive regulation of DNA-directed DNA polymerase activity. Predicted to be part of Ctf18 RFC-like complex and DNA replication factor C complex. Predicted to be active in nucleus. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 104.6), liver E14 (RPKM 51.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rfc2 in Genome Data Viewer
    Location:
    5 G2; 5 74.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134611544..134627182)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134582690..134598328)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11305 Neighboring gene STARR-positive B cell enhancer ABC_E9653 Neighboring gene syncytin a Neighboring gene microRNA 7228 Neighboring gene STARR-positive B cell enhancer ABC_E3628 Neighboring gene STARR-positive B cell enhancer ABC_E8085 Neighboring gene linker for activation of T cells family, member 2 Neighboring gene eukaryotic translation initiation factor 4H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. cDNAs encoding the large subunit of human replication factor C. Bunz F, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248204, Free PMC Article
    2. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Doyle JL, et al. Cytogenet Cell Genet, 2000. PMID 11124535
    3. Integration of a c-myc transgene results in disruption of the mouse Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene hemizygously deleted in Williams-Beuren syndrome. Durkin ME, et al. Genomics, 2001 Apr 1. PMID 11352562
    4. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, et al. Mamm Genome, 2000 Oct. PMID 11003705
    5. RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Vannier JB, et al. Science, 2013 Oct 11. PMID 24115439

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117486

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to DNA clamp loader activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to single-stranded DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-directed DNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ctf18 RFC-like complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 2
    Names
    A1 40 kDa subunit
    RF-C 40 kDa subunit
    RFC40
    activator 1 40 kDa subunit
    activator 1 subunit 2
    replication factor C 40 kDa subunit
    replication factor C, 40 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020022.2 → NP_064406.1  replication factor C subunit 2

      See identical proteins and their annotated locations for NP_064406.1

      Status: VALIDATED

      Source sequence(s)
      AK075997, BY338186
      Consensus CDS
      CCDS19722.1
      UniProtKB/Swiss-Prot
      Q9WUK4
      UniProtKB/TrEMBL
      Q4KL82, Q9D0K3
      Related
      ENSMUSP00000023867.7, ENSMUST00000023867.8
      Conserved Domains (4) summary
      cd00009
      Location:46 → 180
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      PLN03025
      Location:31 → 343
      PLN03025; replication factor C subunit; Provisional
      pfam08542
      Location:269 → 337
      Rep_fac_C; Replication factor C C-terminal domain
      pfam16193
      Location:203 → 231
      AAA_assoc_2; AAA C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134611544..134627182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUK4.1 GenPept UniProtKB/Swiss-Prot:Q9WUK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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