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    Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit [ Mus musculus (house mouse) ]

    Gene ID: 56451, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Suclg1provided by MGI
    Official Full Name
    succinate-CoA ligase, GDP-forming, alpha subunitprovided by MGI
    Primary source
    MGI:MGI:1927234
    See related
    Ensembl:ENSMUSG00000052738 AllianceGenome:MGI:1927234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sucla1; 1500000I01Rik
    Summary
    Predicted to enable GDP binding activity; succinate-CoA ligase (ADP-forming) activity; and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 105.3), heart adult (RPKM 103.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Suclg1 in Genome Data Viewer
    Location:
    6 C1; 6 32.4 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (73225488..73253890)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (73248505..73276907)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 6 Neighboring gene predicted gene, 24533 Neighboring gene STARR-seq mESC enhancer starr_16331 Neighboring gene STARR-positive B cell enhancer mm9_chr6:73171622-73171923 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:73198236-73198345 Neighboring gene predicted gene, 40377 Neighboring gene predicted gene, 38834 Neighboring gene predicted gene, 40378 Neighboring gene STARR-seq mESC enhancer starr_16336 Neighboring gene olfactory receptor family 6 subfamily G member 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant. Donti TR, et al. Mol Genet Metab, 2016 Sep. PMID 27484306, Free PMC Article
    2. Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues. Lambeth DO, et al. J Biol Chem, 2004 Aug 27. PMID 15234968
    3. SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression. Yan W, et al. EMBO J, 2024 Jun. PMID 38649537, Free PMC Article
    4. Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. Johnson JD, et al. J Biol Chem, 1998 Oct 16. PMID 9765291
    5. Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. Mattebo A, et al. Sci Rep, 2021 Aug 5. PMID 34354145, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
      Title: SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.
    2. ADP and GDP succinyl-CoA synthetases have different expression patterns and specificity
      Title: Expression of two succinyl-CoA synthetases with different nucleotide specificities in mammalian tissues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (ADP-forming) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables succinate-CoA ligase (GDP-forming) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in succinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of succinate-CoA ligase complex (ADP-forming) ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of succinate-CoA ligase complex (GDP-forming) ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    Names
    SCS-alpha
    succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
    succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
    succinyl-CoA synthetase subunit alpha
    NP_063932.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019879.3 → NP_063932.2  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

      See identical proteins and their annotated locations for NP_063932.2

      Status: VALIDATED

      Source sequence(s)
      AI840979, AK005080, BY061062
      Consensus CDS
      CCDS20246.2
      UniProtKB/Swiss-Prot
      Q8C2C3, Q9DBA3, Q9DCI8, Q9WUM5
      Related
      ENSMUSP00000065113.7, ENSMUST00000064740.9
      Conserved Domains (1) summary
      PTZ00187
      Location:19 → 344
      PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      73225488..73253890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUM5.4 GenPept UniProtKB/Swiss-Prot:Q9WUM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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