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    Ap1b1 adaptor protein complex AP-1, beta 1 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11764, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ap1b1provided by MGI
    Official Full Name
    adaptor protein complex AP-1, beta 1 subunitprovided by MGI
    Primary source
    MGI:MGI:1096368
    See related
    Ensembl:ENSMUSG00000009090 AllianceGenome:MGI:1096368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adtb1; b2b1660Clo
    Summary
    Enables protein kinase binding activity. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Is active in synaptic vesicle. Is expressed in primary sex cord. Used to study Kartagener syndrome; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 38.3), large intestine adult (RPKM 36.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ap1b1 in Genome Data Viewer
    Location:
    11 A1; 11 3.15 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4897320..4992731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4947320..5042794)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene THO complex 5 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 35321 Neighboring gene STARR-seq mESC enhancer starr_28417 Neighboring gene neurofilament, heavy polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5205 Neighboring gene predicted gene, 24958 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene Ewing sarcoma breakpoint region 1 Neighboring gene STARR-positive B cell enhancer ABC_E8383 Neighboring gene rhomboid domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Guilbaud C, et al. Mamm Genome, 1997 Sep. PMID 9271666
    2. The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Gan Y, et al. Nat Cell Biol, 2002 Aug. PMID 12105417
    3. Beta-adaptin: key molecule for microglial scavenger receptor function under oxidative stress. Manzano-León N, et al. Biochem Biophys Res Commun, 2006 Dec 22. PMID 17092488
    4. Coronary anomalies in mice with congenital heart defects. Tomanek RJ, et al. Anat Rec (Hoboken), 2015 Feb. PMID 25266175
    5. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Doray B, et al. Mol Biol Cell, 2007 May. PMID 17360967, Free PMC Article

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in basolateral protein secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in clathrin coat assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in melanosome assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet dense granule organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synaptic vesicle EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in trans-Golgi network membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AP-1 complex subunit beta-1
    Names
    adaptor protein complex AP-1 subunit beta-1
    adaptor-related protein complex AP-1, beta 1 subunit
    beta-adaptin 1
    beta-prime adaptin
    clathrin assembly protein complex 1 beta large chain
    golgi adaptor HA1/AP1 adaptin beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243043.2 → NP_001229972.1  AP-1 complex subunit beta-1 isoform 1

      See identical proteins and their annotated locations for NP_001229972.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
      Source sequence(s)
      AL645522
      UniProtKB/TrEMBL
      Q3TVN4, Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. NM_001243044.2 → NP_001229973.1  AP-1 complex subunit beta-1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL645522
      UniProtKB/TrEMBL
      Q3TVN4
      Conserved Domains (4) summary
      smart00809
      Location:723 → 823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832 → 945
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    3. NM_001355659.2 → NP_001342588.1  AP-1 complex subunit beta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645522
      UniProtKB/TrEMBL
      Q3TVN4, Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    4. NM_001355660.2 → NP_001342589.1  AP-1 complex subunit beta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645522
      UniProtKB/TrEMBL
      Q3TVN4
      Related
      ENSMUSP00000099134.3, ENSMUST00000101613.3
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 949
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    5. NM_001417314.1 → NP_001404243.1  AP-1 complex subunit beta-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645522

    6. NM_007454.4 → NP_031480.2  AP-1 complex subunit beta-1 isoform 2

      See identical proteins and their annotated locations for NP_031480.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL645522
      Consensus CDS
      CCDS36100.1
      UniProtKB/Swiss-Prot
      O35643, Q3TXG4, Q922E2
      UniProtKB/TrEMBL
      Q3TVN4
      Related
      ENSMUSP00000009234.10, ENSMUST00000009234.16
      Conserved Domains (4) summary
      smart00809
      Location:723 → 823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832 → 942
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4897320..4992731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245487.1 → XP_030101347.1  AP-1 complex subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3TVN4
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 949
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    2. XM_030245485.2 → XP_030101345.1  AP-1 complex subunit beta-1 isoform X1

      UniProtKB/TrEMBL
      Q3TVN4, Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    3. XM_030245486.2 → XP_030101346.1  AP-1 complex subunit beta-1 isoform X2

      UniProtKB/TrEMBL
      Q3TVN4
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 949
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    4. XM_030245488.2 → XP_030101348.1  AP-1 complex subunit beta-1 isoform X3

      UniProtKB/TrEMBL
      Q3TVN4
      Conserved Domains (4) summary
      smart00809
      Location:723 → 823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832 → 945
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    5. XM_030245489.2 → XP_030101349.1  AP-1 complex subunit beta-1 isoform X4

      UniProtKB/Swiss-Prot
      O35643, Q3TXG4, Q922E2
      UniProtKB/TrEMBL
      Q3TVN4
      Conserved Domains (4) summary
      smart00809
      Location:723 → 823
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:832 → 942
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region

    6. XM_006514462.4 → XP_006514525.1  AP-1 complex subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006514525.1

      UniProtKB/TrEMBL
      Q3TVN4, Q8CC13
      Conserved Domains (4) summary
      smart00809
      Location:730 → 830
      Alpha_adaptinC2; Adaptin C-terminal domain
      smart01020
      Location:839 → 952
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:51 → 75
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:11 → 534
      Adaptin_N; Adaptin N terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35643.2 GenPept UniProtKB/Swiss-Prot:O35643

    Gene LinkOut

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