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    Cipc CLOCK interacting protein, circadian [ Mus musculus (house mouse) ]

    Gene ID: 217732, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Cipcprovided by MGI
    Official Full Name
    CLOCK interacting protein, circadianprovided by MGI
    Primary source
    MGI:MGI:1919185
    See related
    Ensembl:ENSMUSG00000034157 AllianceGenome:MGI:1919185
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310044G17Rik
    Summary
    Involved in negative regulation of DNA-templated transcription and negative regulation of circadian rhythm. Located in nucleus. Orthologous to human CIPC (CLOCK interacting pacemaker). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 17.1), colon adult (RPKM 12.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cipc in Genome Data Viewer
    Location:
    12 D2; 12 41.13 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86993817..87012138)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86944741..86965364)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88233078-88233265 Neighboring gene STARR-positive B cell enhancer ABC_E7164 Neighboring gene STARR-seq mESC enhancer starr_32856 Neighboring gene predicted gene, 26698 Neighboring gene predicted gene, 53735 Neighboring gene STARR-seq mESC enhancer starr_32861 Neighboring gene STARR-seq mESC enhancer starr_32863 Neighboring gene STARR-seq mESC enhancer starr_32864 Neighboring gene STARR-positive B cell enhancer ABC_E10769 Neighboring gene predicted gene, 32934 Neighboring gene zinc finger, DHHC-type containing 22 Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice. Qu Z, et al. Sci China Life Sci, 2015 Apr. PMID 25862660
    2. Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice. Zheng J, et al. Cell Rep, 2022 Jun 14. PMID 35705041
    3. Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription. Yoshitane H, et al. Mol Cell Biol, 2009 Jul. PMID 19414601, Free PMC Article
    4. CIPC is a mammalian circadian clock protein without invertebrate homologues. Zhao WN, et al. Nat Cell Biol, 2007 Mar. PMID 17310242
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice.
      Title: Satellite cell-specific deletion of Cipc alleviates myopathy in mdx mice.
    2. mRNA expression profiles of core clock genes in the liver of Cipc (-/-) mice showed no significant differences from that in wild-type mice except for Per1
      Title: Inactivation of Cipc alters the expression of Per1 but not circadian rhythms in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1737, Kiaa1737

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLOCK-interacting pacemaker
    Names
    CLOCK-interacting circadian protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289429.2 → NP_001276358.1  CLOCK-interacting pacemaker isoform b

      See identical proteins and their annotated locations for NP_001276358.1

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    2. NM_001289430.2 → NP_001276359.1  CLOCK-interacting pacemaker isoform a

      See identical proteins and their annotated locations for NP_001276359.1

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Consensus CDS
      CCDS56849.1
      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      UniProtKB/TrEMBL
      A0A087WQN1, Z4YJJ0
      Related
      ENSMUSP00000140266.3, ENSMUST00000189246.7
      Conserved Domains (1) summary
      pfam15800
      Location:52 → 388
      CiPC; Clock interacting protein circadian

    3. NM_001289431.2 → NP_001276360.1  CLOCK-interacting pacemaker isoform b

      See identical proteins and their annotated locations for NP_001276360.1

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    4. NM_001289432.2 → NP_001276361.1  CLOCK-interacting pacemaker isoform b

      See identical proteins and their annotated locations for NP_001276361.1

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    5. NM_001364274.2 → NP_001351203.1  CLOCK-interacting pacemaker isoform b

      Status: VALIDATED

      Source sequence(s)
      AC153147
      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    6. NM_173735.3 → NP_776096.2  CLOCK-interacting pacemaker isoform a

      See identical proteins and their annotated locations for NP_776096.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC153147, AK122546, BI202419, CF530959
      Consensus CDS
      CCDS56849.1
      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      UniProtKB/TrEMBL
      A0A087WQN1, Z4YJJ0
      Related
      ENSMUSP00000038630.5, ENSMUST00000038369.11
      Conserved Domains (1) summary
      pfam15800
      Location:52 → 388
      CiPC; Clock interacting protein circadian

    RNA

    1. NR_157110.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153147

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86993817..87012138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157332.1 → XP_036013225.1  CLOCK-interacting pacemaker isoform X1

      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      Conserved Domains (1) summary
      pfam15800
      Location:118 → 454
      CiPC; Clock interacting protein circadian

    2. XM_011244079.4 → XP_011242381.1  CLOCK-interacting pacemaker isoform X3

      See identical proteins and their annotated locations for XP_011242381.1

      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    3. XM_006515713.5 → XP_006515776.1  CLOCK-interacting pacemaker isoform X3

      See identical proteins and their annotated locations for XP_006515776.1

      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    4. XM_036157334.1 → XP_036013227.1  CLOCK-interacting pacemaker isoform X3

      Conserved Domains (1) summary
      pfam15800
      Location:1 → 317
      CiPC; Clock interacting protein circadian

    5. XM_017315031.3 → XP_017170520.1  CLOCK-interacting pacemaker isoform X2

      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      UniProtKB/TrEMBL
      A0A087WQN1, Z4YJJ0
      Conserved Domains (1) summary
      pfam15800
      Location:52 → 388
      CiPC; Clock interacting protein circadian

    6. XM_036157333.1 → XP_036013226.1  CLOCK-interacting pacemaker isoform X2

      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      UniProtKB/TrEMBL
      A0A087WQN1, Z4YJJ0
      Conserved Domains (1) summary
      pfam15800
      Location:52 → 388
      CiPC; Clock interacting protein circadian

    7. XM_006515712.5 → XP_006515775.1  CLOCK-interacting pacemaker isoform X2

      See identical proteins and their annotated locations for XP_006515775.1

      UniProtKB/Swiss-Prot
      Q3TUN6, Q3U423, Q3UFM0, Q80T99, Q8C680, Q8R0W1
      UniProtKB/TrEMBL
      A0A087WQN1, Z4YJJ0
      Conserved Domains (1) summary
      pfam15800
      Location:52 → 388
      CiPC; Clock interacting protein circadian
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0W1.4 GenPept UniProtKB/Swiss-Prot:Q8R0W1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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