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    Myl4 myosin, light polypeptide 4 [ Mus musculus (house mouse) ]

    Gene ID: 17896, updated on 29-Oct-2024

    Summary

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    Official Symbol
    Myl4provided by MGI
    Official Full Name
    myosin, light polypeptide 4provided by MGI
    Primary source
    MGI:MGI:97267
    See related
    Ensembl:ENSMUSG00000061086 AllianceGenome:MGI:97267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ELC; GT1; ALC1; AMLC; Myla; ELC1a; MLC1a; MLC1EMB
    Summary
    Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in cardiac muscle contraction; positive regulation of ATP-dependent activity; and regulation of the force of heart contraction. Predicted to be part of myosin II complex. Predicted to be active in A band. Is expressed in several structures, including alimentary system; brain; great vessel of heart; heart; and limb. Human ortholog(s) of this gene implicated in cardiomyopathy and familial atrial fibrillation. Orthologous to human MYL4 (myosin light chain 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in heart adult (RPKM 169.8), limb E14.5 (RPKM 32.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myl4 in Genome Data Viewer
    Location:
    11 E1; 11 67.79 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104427604..104478041)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104546017..104587215)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene predicted gene, 22743 Neighboring gene STARR-seq mESC enhancer starr_30878 Neighboring gene STARR-seq mESC enhancer starr_30880 Neighboring gene STARR-seq mESC enhancer starr_30882 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:104286345-104286585 Neighboring gene STARR-seq mESC enhancer starr_30888 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104322909-104323210 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104330691-104330991 Neighboring gene STARR-seq mESC enhancer starr_30889 Neighboring gene cell division cycle 27 Neighboring gene STARR-seq mESC enhancer starr_30890 Neighboring gene STARR-positive B cell enhancer ABC_E5284 Neighboring gene predicted gene 11665 Neighboring gene STARR-positive B cell enhancer ABC_E7075 Neighboring gene TROVE domain family, member 2 pseudogene Neighboring gene lin-52 DREAM MuvB core complex component, pseudogene Neighboring gene STARR-seq mESC enhancer starr_30892 Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr11:104469193-104469494 Neighboring gene STARR-positive B cell enhancer mm9_chr11:104483926-104484227 Neighboring gene STARR-positive B cell enhancer ABC_E1434 Neighboring gene integrin beta 3 Neighboring gene ribosomal protein L3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Myosin essential light chain in health and disease. Hernandez OM, et al. Am J Physiol Heart Circ Physiol, 2007 Apr. PMID 17142342
    2. The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle. Miller MS, et al. J Biol Chem, 2005 Oct 14. PMID 16085933
    3. A skeletal muscle-specific enhancer regulated by factors binding to E and CArG boxes is present in the promoter of the mouse myosin light-chain 1A gene. Catala F, et al. Mol Cell Biol, 1995 Aug. PMID 7623850, Free PMC Article
    4. Functional significance of cardiac myosin essential light chain isoform switching in transgenic mice. Fewell JG, et al. J Clin Invest, 1998 Jun 15. PMID 9637696, Free PMC Article
    5. The role of the N-terminus of the myosin essential light chain in cardiac muscle contraction. Kazmierczak K, et al. J Mol Biol, 2009 Apr 3. PMID 19361417, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene expression of myosin light chain 1 atrial isoform is regulated by BOB.1/OBF.1 coactivator.
      Title: Myosin light chain 1 atrial isoform (MLC1A) is expressed in pre-B cells under control of the BOB.1/OBF.1 coactivator.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin monomer binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ATP-dependent activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in A band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in A band ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain 4
    Names
    myosin light chain, alkali, cardiac atria
    myosin, light polypeptide 4, alkali; atrial, embryonic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355754.1 → NP_001342683.1  myosin light chain 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA014929, AA230721, AK013098, AL603709, CO041482
      Consensus CDS
      CCDS25535.1
      UniProtKB/TrEMBL
      A2A6Q8, Q9CZ19
      Related
      ENSMUSP00000102570.2, ENSMUST00000106957.8
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    2. NM_001355755.1 → NP_001342684.1  myosin light chain 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA230721, AI893273, AK013098, AL603709, BY107860, CO041482
      Consensus CDS
      CCDS25535.1
      UniProtKB/TrEMBL
      A2A6Q8, Q9CZ19
      Related
      ENSMUSP00000102569.4, ENSMUST00000106956.10
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    3. NM_010858.5 → NP_034988.2  myosin light chain 4

      See identical proteins and their annotated locations for NP_034988.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA230721, AK013098, AL603709, CO041482
      Consensus CDS
      CCDS25535.1
      UniProtKB/TrEMBL
      A2A6Q8, Q9CZ19
      Related
      ENSMUSP00000018800.3, ENSMUST00000018800.9
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      104427604..104478041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245638.2 → XP_030101498.1  myosin light chain 4 isoform X2

      UniProtKB/TrEMBL
      A2A6Q8, Q9CZ19
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    2. XM_030245636.1 → XP_030101496.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A2A6Q8
      Conserved Domains (1) summary
      PTZ00184
      Location:62 → 204
      PTZ00184; calmodulin; Provisional

    3. XM_030245637.1 → XP_030101497.1  myosin light chain 4 isoform X2

      UniProtKB/TrEMBL
      A2A6Q8, Q9CZ19
      Related
      ENSMUSP00000114345.2, ENSMUST00000153761.8
      Conserved Domains (1) summary
      PTZ00184
      Location:45 → 192
      PTZ00184; calmodulin; Provisional

    4. XM_030245635.2 → XP_030101495.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A2A6Q8
      Conserved Domains (1) summary
      PTZ00184
      Location:62 → 204
      PTZ00184; calmodulin; Provisional

    5. XM_030245634.1 → XP_030101494.1  myosin light chain 4 isoform X1

      UniProtKB/TrEMBL
      A2A6Q8
      Conserved Domains (1) summary
      PTZ00184
      Location:62 → 204
      PTZ00184; calmodulin; Provisional

    6. XM_036156399.1 → XP_036012292.1  myosin light chain 4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09541.3 GenPept UniProtKB/Swiss-Prot:P09541

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