U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Smyd2 SET and MYND domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 226830, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Smyd2provided by MGI
    Official Full Name
    SET and MYND domain containing 2provided by MGI
    Primary source
    MGI:MGI:1915889
    See related
    Ensembl:ENSMUSG00000026603 AllianceGenome:MGI:1915889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT3C; Zmynd14; 4930402C15; 1110020E07Rik
    Summary
    Enables RNA polymerase II complex binding activity and histone H3K36 methyltransferase activity. Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Located in cytosol and nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; nasal cavity epithelium; and nervous system. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 31.3), heart adult (RPKM 30.2) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Smyd2 in Genome Data Viewer
    Location:
    1 H6; 1 95.03 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189612689..189654758, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189880492..189922495, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191654884-191655189 Neighboring gene STARR-seq mESC enhancer starr_03408 Neighboring gene STARR-seq mESC enhancer starr_03409 Neighboring gene predicted gene, 30280 Neighboring gene predicted gene, 26574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191691042-191691151 Neighboring gene STARR-seq mESC enhancer starr_03412 Neighboring gene STARR-seq mESC enhancer starr_03413 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191796963-191797263 Neighboring gene STARR-seq mESC enhancer starr_03414 Neighboring gene predicted gene, 39736 Neighboring gene predicted gene, 30446

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis. Liu L, et al. FASEB J, 2021 Jul. PMID 34143514, Free PMC Article
    2. Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide. Li J, et al. Oncogene, 2024 Mar. PMID 38243079
    3. SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin. Zhou Y, et al. Cell Mol Life Sci, 2023 Aug 24. PMID 37615725, Free PMC Article
    4. Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation. Su H, et al. Cell Death Dis, 2022 Oct 21. PMID 36270984, Free PMC Article
    5. Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke. Wang J, et al. Clin Transl Med, 2022 Mar. PMID 35297562, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMYD2-Methylated PPARgamma Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy.
      Title: SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy.
    2. Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
      Title: Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
    3. SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
      Title: SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
    4. Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
      Title: Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
    5. Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
      Title: Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
    6. SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
      Title: SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
    7. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
      Title: Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
    8. Our data indicate that Smyd2 has a critical role downstream of Myc in acute myeloid leukemia
      Title: Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
    9. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2.
      Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
    10. a pivotal role for SMYD2 in promoting pancreatic cancer.
      Title: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K36 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H3K4 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-lysine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heart development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-lysine dimethylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine monomethylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-lysine monomethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    N-lysine methyltransferase SMYD2
    Names
    SET and MYND domain-containing protein 2
    histone methyltransferase SMYD2
    NP_081072.1
    XP_006497209.1
    XP_006497210.1
    XP_017175675.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026796.2 → NP_081072.1  N-lysine methyltransferase SMYD2

      See identical proteins and their annotated locations for NP_081072.1

      Status: VALIDATED

      Source sequence(s)
      AC140250, AK003853, AK150857, W76826
      Consensus CDS
      CCDS35821.1
      UniProtKB/Swiss-Prot
      Q3UBQ2, Q8R5A0
      Related
      ENSMUSP00000027897.8, ENSMUST00000027897.8
      Conserved Domains (3) summary
      pfam13424
      Location:381 → 426
      TPR_12; Tetratricopeptide repeat
      cd19202
      Location:7 → 269
      SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins
      pfam01753
      Location:52 → 90
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      189612689..189654758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497146.5 → XP_006497209.1  N-lysine methyltransferase SMYD2 isoform X1

      Conserved Domains (2) summary
      pfam13424
      Location:344 → 389
      TPR_12; Tetratricopeptide repeat
      cd19202
      Location:7 → 232
      SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins

    2. XM_017320186.1 → XP_017175675.1  N-lysine methyltransferase SMYD2 isoform X3

      UniProtKB/TrEMBL
      Q9D177
      Conserved Domains (2) summary
      pfam13424
      Location:177 → 222
      TPR_12; Tetratricopeptide repeat
      cl40432
      Location:1 → 65
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

    3. XM_006497147.5 → XP_006497210.1  N-lysine methyltransferase SMYD2 isoform X2

      Conserved Domains (2) summary
      pfam01753
      Location:52 → 90
      zf-MYND; MYND finger
      cl40432
      Location:7 → 178
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R5A0.1 GenPept UniProtKB/Swiss-Prot:Q8R5A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous