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    Klk11 kallikrein related-peptidase 11 [ Mus musculus (house mouse) ]

    Gene ID: 56538, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klk11provided by MGI
    Official Full Name
    kallikrein related-peptidase 11provided by MGI
    Primary source
    MGI:MGI:1929977
    See related
    Ensembl:ENSMUSG00000067616 AllianceGenome:MGI:1929977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TLSP; Prss20; 2310015I08Rik
    Summary
    This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, May 2016]
    Expression
    Biased expression in stomach adult (RPKM 11.7), lung adult (RPKM 4.1) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klk11 in Genome Data Viewer
    Location:
    7 B3; 7 28.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43424041..43428687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43774617..43779263)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310002F09 gene Neighboring gene kallikrein related-peptidase 12 Neighboring gene kallikrein related-peptidase 10 Neighboring gene kallikrein related-peptidase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder. Gong Z, et al. Br J Dermatol, 2023 Jan 23. PMID 36689511
    2. KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy. Wang Y, et al. BMC Cardiovasc Disord, 2021 May 31. PMID 34059001, Free PMC Article
    3. Deficiency of KLF4 compromises the lung function in an acute mouse model of allergic asthma. Nimpong JA, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28867182, Free PMC Article
    4. cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20). Mitsui S, et al. Biochim Biophys Acta, 2000 Nov 15. PMID 11072088
    5. Differences in Kallikrein-related peptidase mRNA sequences and KLK6 enzyme activity between mouse strains. Murakami K, et al. Protein Pept Lett, 2014. PMID 25666037

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder.
      Title: Variants in KLK11, affecting signal peptide cleavage of kallikrein-related peptidase 11, cause an autosomal-dominant cornification disorder.
    2. KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
      Title: KLK11 promotes the activation of mTOR and protein synthesis to facilitate cardiac hypertrophy.
    3. Together, our results suggest that KLF4 regulates asthma development in a TSLP- and fibrocyte-dependent manner.
      Title: Deficiency of KLF4 compromises the lung function in an acute mouse model of allergic asthma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144345

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kallikrein-11
    Names
    hippostasin
    serine protease 20

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177373.1 → NP_001170844.1  kallikrein-11 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001170844.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB016226, AK009360
      Consensus CDS
      CCDS52227.1
      UniProtKB/Swiss-Prot
      Q9QYN3, Q9QYN4
      UniProtKB/TrEMBL
      A0A0B6VLT0
      Related
      ENSMUSP00000079101.6, ENSMUST00000080211.12
      Conserved Domains (2) summary
      smart00020
      Location:47 → 269
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:48 → 272
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_019974.2 → NP_064358.1  kallikrein-11 isoform 2

      See identical proteins and their annotated locations for NP_064358.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AB016226, AC151989
      Consensus CDS
      CCDS39935.1
      UniProtKB/TrEMBL
      A0A1R3UCI4
      Related
      ENSMUSP00000132721.2, ENSMUST00000171458.2
      Conserved Domains (1) summary
      smart00020
      Location:20 → 242
      Tryp_SPc; Trypsin-like serine protease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43424041..43428687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541006.5 → XP_006541069.1  kallikrein-11 isoform X2

      Conserved Domains (1) summary
      smart00020
      Location:3 → 156
      Tryp_SPc; Trypsin-like serine protease

    2. XM_017322379.2 → XP_017177868.2  kallikrein-11 isoform X1

      UniProtKB/TrEMBL
      A7E201
      Conserved Domains (1) summary
      cd00190
      Location:7 → 185
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYN3.1 GenPept UniProtKB/Swiss-Prot:Q9QYN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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