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    Ehbp1 EH domain binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 216565, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ehbp1provided by MGI
    Official Full Name
    EH domain binding protein 1provided by MGI
    Primary source
    MGI:MGI:2667252
    See related
    Ensembl:ENSMUSG00000042302 AllianceGenome:MGI:2667252
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NACSIN; Flj21950
    Summary
    Predicted to be involved in endocytosis and protein transport. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Is expressed in brain. Orthologous to human EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 12.7), CNS E14 (RPKM 11.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ehbp1 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.1 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (21955825..22237086, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (22005825..22287083, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28856 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene predicted gene, 53673 Neighboring gene orthodenticle homeobox 1 Neighboring gene predicted gene, 51938 Neighboring gene STARR-seq mESC enhancer starr_28857 Neighboring gene STARR-positive B cell enhancer ABC_E584 Neighboring gene predicted gene, 53674 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28858 Neighboring gene STARR-seq mESC enhancer starr_28859 Neighboring gene ribosomal protein SA, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton. Guilherme A, et al. J Biol Chem, 2004 Mar 12. PMID 14676205
    2. Genetic predisposition to tinnitus in the UK Biobank population. Urbanek ME, et al. Sci Rep, 2021 Sep 13. PMID 34518561, Free PMC Article
    3. EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Nakajo A, et al. J Cell Biol, 2016 Feb 1. PMID 26833786, Free PMC Article
    4. Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes. Guilherme A, et al. J Biol Chem, 2004 Sep 17. PMID 15247266
    5. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. Fuchs S, et al. BMC Genet, 2002 Aug 13. PMID 12174196, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EHD1 and EHBP1, but not EHD2, are required for perinuclear localization of GLUT4 and reveal that loss of EHBP1 disrupts insulin-regulated GLUT4 recycling in cultured adipocytes.
      Title: Role of EHD1 and EHBP1 in perinuclear sorting and insulin-regulated GLUT4 recycling in 3T3-L1 adipocytes.
    2. EHBP1 is an EH domain binding protein that, along with EHD2, has a role in coupling endocytosis to the actin cytoskeleton [EHBP1]
      Title: EHD2 and the novel EH domain binding protein EHBP1 couple endocytosis to the actin cytoskeleton.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EH domain-binding protein 1
    Names
    DNA sequence AF424697

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252515.1 → NP_001239444.1  EH domain-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001239444.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF424697, AK173055, BC037023
      Consensus CDS
      CCDS56762.1
      UniProtKB/Swiss-Prot
      E9QMJ9, Q5SQK3, Q69ZW3, Q91ZJ6
      Related
      ENSMUSP00000105191.3, ENSMUST00000109563.9
      Conserved Domains (3) summary
      pfam00307
      Location:457 → 553
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1070 → 1210
      DUF3585; Protein of unknown function (DUF3585)

    2. NM_153078.4 → NP_694718.4  EH domain-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_694718.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AF424697, AK173055, BC037023
      Consensus CDS
      CCDS24469.1
      UniProtKB/Swiss-Prot
      Q69ZW3
      Related
      ENSMUSP00000136697.2, ENSMUST00000180360.8
      Conserved Domains (4) summary
      COG0419
      Location:872 → 1202
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1052 → 1180
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      21955825..22237086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156528.1 → XP_036012421.1  EH domain-binding protein 1 isoform X14

      Related
      ENSMUSP00000037489.5, ENSMUST00000045167.11
      Conserved Domains (4) summary
      COG0419
      Location:872 → 1202
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1052 → 1180
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    2. XM_011243681.4 → XP_011241983.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241983.1

      Conserved Domains (4) summary
      COG0419
      Location:920 → 1253
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1100 → 1236
      DUF3585; Protein of unknown function (DUF3585)

    3. XM_011243684.4 → XP_011241986.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241986.1

      Conserved Domains (4) summary
      COG0419
      Location:920 → 1253
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1100 → 1236
      DUF3585; Protein of unknown function (DUF3585)

    4. XM_030245788.2 → XP_030101648.1  EH domain-binding protein 1 isoform X7

      Conserved Domains (4) summary
      COG0419
      Location:885 → 1218
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1068 → 1196
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:419 → 525
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    5. XM_017314437.3 → XP_017169926.1  EH domain-binding protein 1 isoform X5

      Conserved Domains (4) summary
      COG0419
      Location:895 → 1228
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1078 → 1206
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    6. XM_011243683.4 → XP_011241985.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241985.1

      Conserved Domains (4) summary
      COG0419
      Location:920 → 1253
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1100 → 1236
      DUF3585; Protein of unknown function (DUF3585)

    7. XM_036156526.1 → XP_036012419.1  EH domain-binding protein 1 isoform X7

      Conserved Domains (4) summary
      COG0419
      Location:885 → 1218
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1068 → 1196
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:419 → 525
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    8. XM_036156530.1 → XP_036012423.1  EH domain-binding protein 1 isoform X21

      Conserved Domains (4) summary
      COG1196
      Location:900 → 1186
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1035 → 1163
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    9. XM_036156524.1 → XP_036012417.1  EH domain-binding protein 1 isoform X5

      Conserved Domains (4) summary
      COG0419
      Location:895 → 1228
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1078 → 1206
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    10. XM_036156523.1 → XP_036012416.1  EH domain-binding protein 1 isoform X3

      Conserved Domains (4) summary
      COG0419
      Location:897 → 1230
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1080 → 1208
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    11. XM_011243682.3 → XP_011241984.1  EH domain-binding protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241984.1

      Conserved Domains (4) summary
      COG0419
      Location:920 → 1253
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1100 → 1236
      DUF3585; Protein of unknown function (DUF3585)

    12. XM_036156535.1 → XP_036012428.1  EH domain-binding protein 1 isoform X30

      Conserved Domains (4) summary
      COG1196
      Location:837 → 1109
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:980 → 1108
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:394 → 500
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    13. XM_036156534.1 → XP_036012427.1  EH domain-binding protein 1 isoform X29

      Conserved Domains (4) summary
      COG1196
      Location:840 → 1135
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:984 → 1112
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:394 → 500
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    14. XM_030245791.2 → XP_030101651.1  EH domain-binding protein 1 isoform X17

      Conserved Domains (4) summary
      COG0419
      Location:860 → 1193
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:397 → 499
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1040 → 1176
      DUF3585; Protein of unknown function (DUF3585)

    15. XM_030245796.2 → XP_030101656.1  EH domain-binding protein 1 isoform X26

      Conserved Domains (4) summary
      COG1196
      Location:864 → 1159
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:422 → 524
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1005 → 1141
      DUF3585; Protein of unknown function (DUF3585)

    16. XM_036156532.1 → XP_036012425.1  EH domain-binding protein 1 isoform X27

      Conserved Domains (4) summary
      COG1196
      Location:760 → 1135
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1006 → 1134
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:419 → 525
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    17. XM_017314440.3 → XP_017169929.1  EH domain-binding protein 1 isoform X25

      Conserved Domains (4) summary
      COG1196
      Location:760 → 1138
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:422 → 524
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1006 → 1142
      DUF3585; Protein of unknown function (DUF3585)

    18. XM_011243693.4 → XP_011241995.1  EH domain-binding protein 1 isoform X15

      Conserved Domains (4) summary
      COG0419
      Location:862 → 1195
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:422 → 524
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1042 → 1178
      DUF3585; Protein of unknown function (DUF3585)

    19. XM_011243689.4 → XP_011241991.1  EH domain-binding protein 1 isoform X7

      Conserved Domains (4) summary
      COG0419
      Location:885 → 1218
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1068 → 1196
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:419 → 525
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    20. XM_036156531.1 → XP_036012424.1  EH domain-binding protein 1 isoform X22

      Conserved Domains (4) summary
      COG0419
      Location:782 → 1182
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1032 → 1160
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    21. XM_030245789.2 → XP_030101649.1  EH domain-binding protein 1 isoform X13

      Conserved Domains (4) summary
      COG0419
      Location:872 → 1205
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:432 → 534
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1052 → 1188
      DUF3585; Protein of unknown function (DUF3585)

    22. XM_011243688.4 → XP_011241990.1  EH domain-binding protein 1 isoform X5

      Conserved Domains (4) summary
      COG0419
      Location:895 → 1228
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1078 → 1206
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:429 → 535
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    23. XM_011243692.4 → XP_011241994.1  EH domain-binding protein 1 isoform X11

      Conserved Domains (4) summary
      COG0419
      Location:807 → 1209
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1056 → 1192
      DUF3585; Protein of unknown function (DUF3585)

    24. XM_030245795.2 → XP_030101655.1  EH domain-binding protein 1 isoform X24

      Conserved Domains (4) summary
      COG1196
      Location:752 → 1150
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1018 → 1154
      DUF3585; Protein of unknown function (DUF3585)

    25. XM_030245794.2 → XP_030101654.1  EH domain-binding protein 1 isoform X23

      Conserved Domains (4) summary
      COG1196
      Location:752 → 1153
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1021 → 1157
      DUF3585; Protein of unknown function (DUF3585)

    26. XM_017314438.3 → XP_017169927.1  EH domain-binding protein 1 isoform X12

      Conserved Domains (4) summary
      COG0419
      Location:807 → 1207
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1054 → 1190
      DUF3585; Protein of unknown function (DUF3585)

    27. XM_011243691.4 → XP_011241993.1  EH domain-binding protein 1 isoform X10

      Conserved Domains (4) summary
      COG0419
      Location:807 → 1210
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1057 → 1193
      DUF3585; Protein of unknown function (DUF3585)

    28. XM_030245792.2 → XP_030101652.1  EH domain-binding protein 1 isoform X20

      Conserved Domains (4) summary
      COG1196
      Location:897 → 1169
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1037 → 1173
      DUF3585; Protein of unknown function (DUF3585)

    29. XM_036156529.1 → XP_036012422.1  EH domain-binding protein 1 isoform X18

      Conserved Domains (4) summary
      COG1196
      Location:899 → 1194
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1043 → 1171
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    30. XM_036156525.1 → XP_036012418.1  EH domain-binding protein 1 isoform X6

      Conserved Domains (4) summary
      COG0419
      Location:896 → 1226
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1076 → 1204
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    31. XM_011243687.4 → XP_011241989.1  EH domain-binding protein 1 isoform X4

      Conserved Domains (4) summary
      COG0419
      Location:896 → 1229
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1076 → 1212
      DUF3585; Protein of unknown function (DUF3585)

    32. XM_017314439.3 → XP_017169928.1  EH domain-binding protein 1 isoform X19

      Conserved Domains (4) summary
      COG1196
      Location:795 → 1170
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1038 → 1174
      DUF3585; Protein of unknown function (DUF3585)

    33. XM_030245790.2 → XP_030101650.1  EH domain-binding protein 1 isoform X16

      Conserved Domains (4) summary
      COG1196
      Location:795 → 1173
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1041 → 1177
      DUF3585; Protein of unknown function (DUF3585)

    34. XM_011243686.4 → XP_011241988.1  EH domain-binding protein 1 isoform X3

      Conserved Domains (4) summary
      COG0419
      Location:897 → 1230
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1080 → 1208
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    35. XM_036156527.1 → XP_036012420.1  EH domain-binding protein 1 isoform X9

      Conserved Domains (4) summary
      COG1196
      Location:921 → 1193
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1064 → 1192
      DUF3585; Protein of unknown function (DUF3585)
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins

    36. XM_011243690.4 → XP_011241992.1  EH domain-binding protein 1 isoform X8

      Conserved Domains (4) summary
      COG1196
      Location:923 → 1218
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1064 → 1200
      DUF3585; Protein of unknown function (DUF3585)

    37. XM_011243685.4 → XP_011241987.1  EH domain-binding protein 1 isoform X2

      Conserved Domains (4) summary
      COG0419
      Location:920 → 1250
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam00307
      Location:457 → 559
      CH; Calponin homology (CH) domain
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1097 → 1233
      DUF3585; Protein of unknown function (DUF3585)

    38. XM_036156533.1 → XP_036012426.1  EH domain-binding protein 1 isoform X28

      Conserved Domains (2) summary
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      cd21254
      Location:454 → 560
      CH_EHBP1; calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZW3.3 GenPept UniProtKB/Swiss-Prot:Q69ZW3

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