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    Snrnp200 small nuclear ribonucleoprotein 200 (U5) [ Mus musculus (house mouse) ]

    Gene ID: 320632, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Snrnp200provided by MGI
    Official Full Name
    small nuclear ribonucleoprotein 200 (U5)provided by MGI
    Primary source
    MGI:MGI:2444401
    See related
    Ensembl:ENSMUSG00000003660 AllianceGenome:MGI:2444401
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HELIC2; Ascc3l1; U5-200KD; U5-200-KD; A330064G03Rik
    Summary
    On February 19, 2002, this locus was switched from human to mouse. The source accession, Z70200.1, is almost identical to the mouse BAC clone AC074224, and it matches the mouse cDNA accession BC011390 as well. The human gene is LocusID 23020. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thymus adult (RPKM 28.4), CNS E11.5 (RPKM 26.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Snrnp200 in Genome Data Viewer
    Location:
    2 F1; 2 61.84 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127050306..127082373)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127208386..127240453)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E8792 Neighboring gene STARR-seq mESC enhancer starr_05621 Neighboring gene RIKEN cDNA 1810024B03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3401 Neighboring gene STARR-positive B cell enhancer ABC_E642 Neighboring gene cytosolic iron-sulfur protein assembly 1 Neighboring gene transmembrane protein 127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases. Lauber J, et al. EMBO J, 1996 Aug 1. PMID 8670905, Free PMC Article
    2. Comparative sequence analysis of a single-gene conserved segment in mouse and human. Thomas JW, et al. Mamm Genome, 2003 Oct. PMID 14694903
    3. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
    4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0788

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 1 spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U5 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U5 snRNP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U5 small nuclear ribonucleoprotein 200 kDa helicase
    Names
    BRR2 homolog
    U5 snRNP-specific protein, 200 kDa (DEXH RNA helicase family)
    activating signal cointegrator 1 complex subunit 3-like 1
    NP_796188.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177214.5 → NP_796188.2  U5 small nuclear ribonucleoprotein 200 kDa helicase

      See identical proteins and their annotated locations for NP_796188.2

      Status: VALIDATED

      Source sequence(s)
      AL845368
      Consensus CDS
      CCDS16695.1
      UniProtKB/Swiss-Prot
      Q69ZZ3, Q6P4T2
      Related
      ENSMUSP00000099509.4, ENSMUST00000103220.4
      Conserved Domains (7) summary
      smart00490
      Location:1616 → 1694
      HELICc; helicase superfamily c-terminal domain
      smart00487
      Location:1320 → 1508
      DEXDc; DEAD-like helicases superfamily
      smart00611
      Location:1809 → 2125
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:452 → 1241
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd00079
      Location:684 → 870
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:1329 → 1500
      DEAD; DEAD/DEAH box helicase
      pfam02889
      Location:982 → 1285
      Sec63; Sec63 Brl domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      127050306..127082373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4T2.1 GenPept UniProtKB/Swiss-Prot:Q6P4T2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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