Slc30a4 solute carrier family 30 (zinc transporter), member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a4provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 4provided by MGI
Primary source: MGI:MGI:1345282
See related: Ensembl:ENSMUSG00000005802 AllianceGenome:MGI:1345282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: lm; Znt4; znT-4
Summary: Enables zinc ion transmembrane transporter activity. Involved in zinc ion transmembrane transport. Acts upstream of or within zinc export across plasma membrane. Predicted to be located in endosome membrane and late endosome. Predicted to be active in plasma membrane. Is expressed in medulla oblongata basal plate mantle layer and placenta. Orthologous to human SLC30A4 (solute carrier family 30 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 14.9), placenta adult (RPKM 9.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (122523153..122544583, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (122681233..122702663, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
Title: MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway.
Loss of ZnT4 has profound consequences on mammary epithelial cell secretion and may promote tissue remodeling in the mammary gland during early lactation.
Title: ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.
It was shown that that ZnT4 transports Zn into the trans-Golgi network, which is critical for key secretory functions of the mammary cell.
Title: ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells.
Expression of zinc transporter ZnT4 in mouse choroid epithelial cells suggests that the choroid plexus plays an important role in regulation of zinc homeostasis in the brain.
Title: Dynamic zinc pools in mouse choroid plexus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Spontaneous (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a4 (e-PCR), detects polymorphism
- UniSTS:547333

AF003747 (e-PCR)
- UniSTS:178697

Slc30a4 (e-PCR), detects polymorphism
- UniSTS:462699

RH136936 (e-PCR)
- UniSTS:219025

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion import into lysosome	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable proton-coupled zinc antiporter SLC30A4

Names: lethal milk protein; solute carrier family 30 (zinc transporter), member 4; zinc transporter 4; solute carrier family 30 member 4; zinc transporter 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290993.1 → NP_001277922.1 probable proton-coupled zinc antiporter SLC30A4 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK134245, AL772253, AW125676, CO432407, CV556160

Consensus CDS

CCDS71131.1

UniProtKB/TrEMBL

A2AK40, Q3TM66

Related

ENSMUSP00000097056.4, ENSMUST00000099457.4

Conserved Domains (2) summary

TIGR01297
Location:131 → 365

CDF; cation diffusion facilitator family transporter

pfam01545
Location:130 → 284

Cation_efflux; Cation efflux family
NM_011774.3 → NP_035904.2 probable proton-coupled zinc antiporter SLC30A4 isoform a

See identical proteins and their annotated locations for NP_035904.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK134245, AL772253, AW125676, CO432407, CV556160

Consensus CDS

CCDS16667.1

UniProtKB/Swiss-Prot

O35149, O35154, Q3UYZ9

UniProtKB/TrEMBL

Q3TM66

Related

ENSMUSP00000005952.5, ENSMUST00000005952.11

Conserved Domains (2) summary

TIGR01297
Location:123 → 414

CDF; cation diffusion facilitator family transporter

pfam01545
Location:123 → 333

Cation_efflux; Cation efflux family