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    Bpifb3 BPI fold containing family B, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 378700, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bpifb3provided by MGI
    Official Full Name
    BPI fold containing family B, member 3provided by MGI
    Primary source
    MGI:MGI:2675077
    See related
    Ensembl:ENSMUSG00000068008 AllianceGenome:MGI:2675077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rya3; Lplunc3
    Summary
    Predicted to enable lipid binding activity. Predicted to be located in cytoplasm. Is expressed in testis. Orthologous to human BPIFB3 (BPI fold containing family B member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 2.3), mammary gland adult (RPKM 0.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bpifb3 in Genome Data Viewer
    Location:
    2 H1; 2 75.99 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153760118..153774916)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (153918198..153932996)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BPI fold containing family B, member 2 Neighboring gene BPI fold containing family B, member 6 Neighboring gene BPI fold containing family B, member 4 Neighboring gene BPI fold containing family A, member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expansion of the BPI family by duplication on human chromosome 20: characterization of the RY gene cluster in 20q11.21 encoding olfactory transporters/antimicrobial-like peptides. Andrault JB, et al. Genomics, 2003 Aug. PMID 12837268
    2. Phylogenetic and evolutionary analysis of the PLUNC gene family. Bingle CD, et al. Protein Sci, 2004 Feb. PMID 14739326, Free PMC Article
    3. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Bingle CD, et al. Biochem Soc Trans, 2011 Aug. PMID 21787333, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPI fold-containing family B member 3
    Names
    antimicrobial peptide RYA3
    ligand-binding protein RYA3
    long palate, lung and nasal epithelium carcinoma-associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379473.1 → NP_001366402.1  BPI fold-containing family B member 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL833803
      UniProtKB/Swiss-Prot
      A2APD1, Q80ZU7
      Related
      ENSMUSP00000105382.2, ENSMUST00000109760.2
      Conserved Domains (2) summary
      smart00329
      Location:273 → 471
      BPI2; BPI/LBP/CETP C-terminal domain
      cl00188
      Location:26 → 249
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

    2. NM_194357.2 → NP_919338.2  BPI fold-containing family B member 3 precursor

      See identical proteins and their annotated locations for NP_919338.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL833803
      Consensus CDS
      CCDS16921.1
      UniProtKB/Swiss-Prot
      A2APD1, Q80ZU7
      Related
      ENSMUSP00000086342.2, ENSMUST00000088950.8
      Conserved Domains (2) summary
      smart00329
      Location:273 → 471
      BPI2; BPI/LBP/CETP C-terminal domain
      cl00188
      Location:26 → 249
      BPI; BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153760118..153774916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZU7.2 GenPept UniProtKB/Swiss-Prot:Q80ZU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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