Or6c74 olfactory receptor family 6 subfamily C member 74 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or6c74provided by MGI
Official Full Name: olfactory receptor family 6 subfamily C member 74provided by MGI
Primary source: MGI:MGI:3030655
See related: Ensembl:ENSMUSG00000044897 AllianceGenome:MGI:3030655
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Olfr821; MOR109-1
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 10 D3; 10 77.67 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (129869497..129870429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (130033628..130034560)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that Olfr15 and Olfr821 in pancreatic beta-cells has a chemo-sensor function allowing recognition of environmental substances obtained from food, and potentiates insulin secretion in a cell-autonomous manner, thereby modulating systemic glucose metabolism.
Title: Olfactory receptors are expressed in pancreatic β-cells and promote glucose-stimulated insulin secretion.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:494350

NoName (e-PCR)
- UniSTS:485160

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed

General protein information

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Preferred Names: olfactory receptor family 6 subfamily C member 74

Names: GA_x6K02T2PULF-11704843-11705775; olfactory receptor 821; olfactory receptor MOR109-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146776.1 → NP_666987.1 olfactory receptor family 6 subfamily C member 74

See identical proteins and their annotated locations for NP_666987.1

Status: PROVISIONAL

Source sequence(s)

AY073318

Consensus CDS

CCDS24346.1

UniProtKB/TrEMBL

Q8VG45

Related

ENSMUSP00000056626.2, ENSMUST00000054364.2

Conserved Domains (2) summary

pfam00001
Location:39 → 288

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:31 → 302

7tm_4; Olfactory receptor