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    Amy2a4 amylase 2a4 [ Mus musculus (house mouse) ]

    Gene ID: 100043684, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Amy2a4provided by MGI
    Official Full Name
    amylase 2a4provided by MGI
    Primary source
    MGI:MGI:3711258
    See related
    Ensembl:ENSMUSG00000096770 AllianceGenome:MGI:3711258
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PA; Amy2; Amy2a; mAmy2-3
    Expression
    Biased expression in spleen adult (RPKM 523.5), small intestine adult (RPKM 403.8) and 2 other tissues See more
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    Genomic context

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    See Amy2a4 in Genome Data Viewer
    Location:
    3 F3; 3 49.35 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113187153..113198765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113279837..113291449, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2, pseudogene 1 Neighboring gene amylase 2a5 Neighboring gene amylase 2a3 Neighboring gene amylase 2a2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland. Hagenbüchle O, et al. Cell, 1980 Aug. PMID 6157477
    2. Comparative genomic analysis of the mouse and rat amylase multigene family. Sugino H. FEBS Lett, 2007 Feb 6. PMID 17223109
    3. The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver. Schibler U, et al. J Mol Biol, 1982 Mar 5. PMID 6176715
    4. Termination of transcription in the mouse alpha-amylase gene Amy-2a occurs at multiple sites downstream of the polyadenylation site. Hagenbüchle O, et al. Cell, 1984 Oct. PMID 6091898
    5. Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters. Hagenbüchle O, et al. J Mol Biol, 1985 Sep 20. PMID 3877171

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-amylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amylase 2a4
    Names
    1,4-alpha-D-glucan glucanohydrolase
    Pancreatic alpha-amylase
    amylase 2a4, pancreatic
    NP_001153622.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160150.1 → NP_001153622.1  amylase 2a4 precursor

      See identical proteins and their annotated locations for NP_001153622.1

      Status: INFERRED

      Source sequence(s)
      AC161580
      Consensus CDS
      CCDS51054.1
      UniProtKB/Swiss-Prot
      P00688, Q4VBW6, Q61295, Q61296, Q64301
      Related
      ENSMUSP00000137025.2, ENSMUST00000179568.3
      Conserved Domains (3) summary
      cd11317
      Location:25 → 413
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:420 → 507
      Aamy_C; Aamy_C domain
      COG0366
      Location:46 → 344
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      113187153..113198765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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