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    Prmt5 protein arginine N-methyltransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 27374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prmt5provided by MGI
    Official Full Name
    protein arginine N-methyltransferase 5provided by MGI
    Primary source
    MGI:MGI:1351645
    See related
    Ensembl:ENSMUSG00000023110 AllianceGenome:MGI:1351645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jbp1; Skb1
    Summary
    This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation and the assembly of small nuclear ribonucleoproteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 31.6), CNS E14 (RPKM 26.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prmt5 in Genome Data Viewer
    Location:
    14 C2; 14 27.82 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54744639..54754927, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54507182..54517470, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene rad and gem related GTP binding protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr14:55113133-55113433 Neighboring gene predicted gene, 41153 Neighboring gene nuclear encoded tRNA arginine 6 (anticodon ACG) Neighboring gene predicted gene, 53858

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRMT5 Is Involved in Spermatogonial Stem Cells Maintenance by Regulating Plzf Expression via Modulation of Lysine Histone Modifications. Dong F, et al. Front Cell Dev Biol, 2021. PMID 34113620, Free PMC Article
    2. Endothelial PRMT5 plays a crucial role in angiogenesis after acute ischemic injury. Ye Q, et al. JCI Insight, 2022 May 9. PMID 35531958, Free PMC Article
    3. Inhibition of PRMT5 suppresses osteoclast differentiation and partially protects against ovariectomy-induced bone loss through downregulation of CXCL10 and RSAD2. Dong Y, et al. Cell Signal, 2017 Jun. PMID 28302565
    4. PRMT5 critically mediates TMAO-induced inflammatory response in vascular smooth muscle cells. Liu H, et al. Cell Death Dis, 2022 Apr 4. PMID 35379776, Free PMC Article
    5. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. Lewis BW, et al. J Immunol, 2022 Apr 1. PMID 35288471, Free PMC Article

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets.
      Title: Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets.
    2. Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
      Title: Excessive fatty acids activate PRMT5/MDM2/Drosha pathway to regulate miRNA biogenesis and lipid metabolism.
    3. PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
      Title: PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.
    4. Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
      Title: Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice.
    5. PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
      Title: PRMT5-mediated homologous recombination repair is essential to maintain genomic integrity of neural progenitor cells.
    6. Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
      Title: Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.
    7. PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
      Title: PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment.
    8. PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
      Title: PRMT5 mediates FoxO1 methylation and subcellular localization to regulate lipophagy in myogenic progenitors.
    9. Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
      Title: Prmt5 deficient mouse B cells display RNA processing complexity and slower colorectal tumor progression.
    10. The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
      Title: The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine.
    Submit: New GeneRIF Correction See all GeneRIFs (79)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H2AR3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4R3 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4R3 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4R3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H4R3 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone arginine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein-arginine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-arginine omega-N symmetric methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-arginine omega-N symmetric methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA-templated transcription termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi ribbon formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endothelial cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression via chromosomal CpG island methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-arginine N-methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidyl-arginine N-methylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in peptidyl-arginine methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-arginine methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spliceosomal snRNP assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spliceosomal snRNP assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of methylosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of methylosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein arginine N-methyltransferase 5
    Names
    Jak-binding protein 1
    SKB1 homolog
    histone-arginine N-methyltransferase PRMT5
    shk1 kinase-binding protein 1 homolog
    NP_001300835.1
    NP_001300836.1
    NP_038796.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313906.1 → NP_001300835.1  protein arginine N-methyltransferase 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK076346, AK084106, AK165165, CF726158
      UniProtKB/Swiss-Prot
      Q3TNN1, Q8CIG8, Q9QZS9
      Conserved Domains (2) summary
      pfam05185
      Location:164 → 600
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:165 → 446
      SAMBD; SAM-binding_domain

    2. NM_001313907.1 → NP_001300836.1  protein arginine N-methyltransferase 5 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK076346, AK084106, AK165165, BY101080
      UniProtKB/Swiss-Prot
      Q3TNN1, Q8CIG8, Q9QZS9
      Conserved Domains (2) summary
      pfam05185
      Location:77 → 513
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:78 → 359
      SAMBD; SAM-binding_domain

    3. NM_013768.3 → NP_038796.2  protein arginine N-methyltransferase 5 isoform 1

      See identical proteins and their annotated locations for NP_038796.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK076346, AK165165, BY064945
      Consensus CDS
      CCDS27091.1
      UniProtKB/Swiss-Prot
      Q3TNN1, Q8CIG8, Q9QZS9
      UniProtKB/TrEMBL
      A0A0R4J049
      Related
      ENSMUSP00000023873.6, ENSMUST00000023873.12
      Conserved Domains (2) summary
      pfam05185
      Location:183 → 619
      PRMT5; PRMT5 arginine-N-methyltransferase
      pfam16950
      Location:184 → 465
      SAMBD; SAM-binding_domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54744639..54754927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIG8.3 GenPept UniProtKB/Swiss-Prot:Q8CIG8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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