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    MKNK1 MAPK interacting serine/threonine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 8569, updated on 14-Nov-2024

    Summary

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    Official Symbol
    MKNK1provided by HGNC
    Official Full Name
    MAPK interacting serine/threonine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:7110
    See related
    Ensembl:ENSG00000079277 MIM:606724; AllianceGenome:HGNC:7110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MNK1
    Summary
    This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
    Expression
    Ubiquitous expression in appendix (RPKM 4.8), pancreas (RPKM 4.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MKNK1 in Genome Data Viewer
    Location:
    1p33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (46557407..46604268, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (46434628..46481501, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47023079..47069940, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 847 Neighboring gene CRISPRi-validated cis-regulatory element chr1.5857 Neighboring gene transmembrane protein 275 Neighboring gene MKNK1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013004-47013504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47013505-47014005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47015442-47016081 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47021539-47022040 Neighboring gene kinocilin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:47022041-47022540 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:47024335-47024504 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:47069254-47069754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:47078933-47079556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 849 Neighboring gene MOB kinase activator 3C Neighboring gene uncharacterized LOC105378697

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MNK1 kinase activity is required for abscission. Rannou Y, et al. J Cell Sci, 2012 Jun 15. PMID 22454512
    2. Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials. Berger MD, et al. Ann Oncol, 2017 Nov 1. PMID 29045529, Free PMC Article
    3. MAP Kinase-Interacting Kinase 1 Promotes Proliferation and Invasion of Hepatocellular Carcinoma and Is an Unfavorable Prognostic Biomarker. Wang X, et al. Med Sci Monit, 2018 Mar 26. PMID 29576605, Free PMC Article
    4. Role of MAPK/MNK1 signaling in virus replication. Kumar R, et al. Virus Res, 2018 Jul 15. PMID 29864503, Free PMC Article
    5. Differential Response of Glioma Stem Cells to Arsenic Trioxide Therapy Is Regulated by MNK1 and mRNA Translation. Bell JB, et al. Mol Cancer Res, 2018 Jan. PMID 29042487, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis.
      Title: Blocking tumor-intrinsic MNK1 kinase restricts metabolic adaptation and diminishes liver metastasis.
    2. MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.
      Title: MNK1 and MNK2 Expression in the Human Dorsal Root and Trigeminal Ganglion.
    3. miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
      Title: miR-370-3p Regulates Adipogenesis through Targeting Mknk1.
    4. MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
      Title: MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis.
    5. MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.
      Title: MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.
    6. Identification of potential autophagy-associated lncRNA in prostate cancer.
      Title: Identification of potential autophagy-associated lncRNA in prostate cancer.
    7. MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.
      Title: MNK1 signaling induces an ANGPTL4-mediated gene signature to drive melanoma progression.
    8. FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.
      Title: FLI1 promotes protein translation via the transcriptional regulation of MKNK1 expression.
    9. phosphorylation pattern of eIF4E responds faithfully to Rapamycin inhibition, the prolonged exposure to Rapamycin rescues the loss of eIF4E phosphorylation through Mnk1 activation.
      Title: Eukaryotic initiation factor 4E is a novel effector of mTORC1 signaling pathway in cross talk with Mnk1.
    10. Loss of MNK1 repressed NODAL expression, inhibited ductal carcinoma in situ to invasive ductal carcinoma conversion, and decreased tumor relapse and metastasis
      Title: MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase 1
    Names
    MAP kinase interacting serine/threonine kinase 1
    MAP kinase signal-integrating kinase 1
    MAPK signal-integrating kinase 1
    NP_001129025.2
    NP_001364266.1
    NP_001364267.1
    NP_001364270.1
    NP_001364271.1
    NP_001364272.1
    NP_001364302.1
    NP_001364303.1
    NP_001364304.1
    NP_003675.3
    NP_945324.2
    XP_006711065.1
    XP_016858149.1
    XP_024306278.1
    XP_047288978.1
    XP_047288980.1
    XP_047288981.1
    XP_047288982.1
    XP_047288995.1
    XP_047288998.1
    XP_047289003.1
    XP_047289009.1
    XP_047289015.1
    XP_047289022.1
    XP_047289035.1
    XP_047289037.1
    XP_054195308.1
    XP_054195309.1
    XP_054195310.1
    XP_054195311.1
    XP_054195312.1
    XP_054195313.1
    XP_054195314.1
    XP_054195315.1
    XP_054195316.1
    XP_054195317.1
    XP_054195318.1
    XP_054195319.1
    XP_054195320.1
    XP_054195321.1
    XP_054195322.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032029.2 RefSeqGene

      Range
      5027..51888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135553.4 → NP_001129025.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal protein segment compared to isoform 1.
      Source sequence(s)
      AB000409, BC002755, BG722049, BM665342, DA502363
      Consensus CDS
      CCDS44134.2
      UniProtKB/TrEMBL
      A0A499FJN1, B5BU64, B5BUJ6
      Related
      ENSP00000361013.5, ENST00000371945.10
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    2. NM_001377337.1 → NP_001364266.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      UniProtKB/TrEMBL
      B5BU64, B5BUJ6
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    3. NM_001377338.1 → NP_001364267.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      UniProtKB/TrEMBL
      B5BU64, B5BUJ6
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    4. NM_001377341.1 → NP_001364270.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      UniProtKB/TrEMBL
      A8K341
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    5. NM_001377342.1 → NP_001364271.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      UniProtKB/TrEMBL
      A8K341
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    6. NM_001377343.1 → NP_001364272.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      Conserved Domains (1) summary
      cl21453
      Location:21 → 279
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001377373.1 → NP_001364302.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      Consensus CDS
      CCDS44134.2
      UniProtKB/TrEMBL
      A0A499FJN1, B5BU64, B5BUJ6
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    8. NM_001377374.1 → NP_001364303.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      Consensus CDS
      CCDS30705.2
      UniProtKB/TrEMBL
      A0A499FJS1, A8K341
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    9. NM_001377375.1 → NP_001364304.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523
      Consensus CDS
      CCDS30705.2
      UniProtKB/TrEMBL
      A0A499FJS1, A8K341
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    10. NM_003684.7 → NP_003675.3  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC002755, BM665342, DA435648, DC366212
      Consensus CDS
      CCDS538.2
      UniProtKB/Swiss-Prot
      D3DQ20, D3DQ21, O00312, Q5TC06, Q5TC07, Q6V0N6, Q9BUB5
      UniProtKB/TrEMBL
      A0A499FIS5
      Related
      ENSP00000361014.5, ENST00000371946.9
      Conserved Domains (1) summary
      cd14174
      Location:34 → 363
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    11. NM_198973.5 → NP_945324.2  MAP kinase-interacting serine/threonine-protein kinase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two coding exons, and uses an alternate donor splice site at the 5' non-coding exon compared to variant 1. The second missing exon results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK290456, BC002755, BG722049, BM665342, DC376088
      Consensus CDS
      CCDS30705.2
      UniProtKB/TrEMBL
      A0A499FJS1, A8K341
      Related
      ENSP00000411135.3, ENST00000428112.7
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    RNA

    1. NR_024174.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK298839, BC002755, BM665342

    2. NR_024176.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an additional exon, and lacks two non-consecutive exons compared to variant 1. It is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AB000409, AK096423, BG722049, BM665342, BX538193
      Related
      ENST00000342571.7

    3. NR_146512.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in its 5' terminal exon, and contains multiple differences in internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK290456, AL136373, BC002755, BM665342, DB273771

    4. NR_165250.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136373, KF459523

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      46557407..46604268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433047.1 → XP_047289003.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

      Related
      ENSP00000339573.6, ENST00000341183.9

    2. XM_047433024.1 → XP_047288980.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

      Related
      ENSP00000498143.1, ENST00000650508.1

    3. XM_047433026.1 → XP_047288982.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    4. XM_047433025.1 → XP_047288981.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    5. XM_047433053.1 → XP_047289009.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    6. XM_006711002.4 → XP_006711065.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

      See identical proteins and their annotated locations for XP_006711065.1

      UniProtKB/TrEMBL
      B5BU64, B5BUJ6
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    7. XM_047433059.1 → XP_047289015.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    8. XM_017002660.3 → XP_016858149.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

      UniProtKB/TrEMBL
      A8K341
      Conserved Domains (1) summary
      cd14174
      Location:40 → 328
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    9. XM_047433039.1 → XP_047288995.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1

    10. XM_047433042.1 → XP_047288998.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1

    11. XM_047433066.1 → XP_047289022.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

    12. XM_047433022.1 → XP_047288978.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    13. XM_024450510.2 → XP_024306278.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1, B5BU64, B5BUJ6
      Conserved Domains (1) summary
      cd14174
      Location:34 → 322
      STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

    14. XM_047433079.1 → XP_047289035.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    15. XM_047433081.1 → XP_047289037.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      46434628..46481501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339341.1 → XP_054195316.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    2. XM_054339334.1 → XP_054195309.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    3. XM_054339336.1 → XP_054195311.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    4. XM_054339335.1 → XP_054195310.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

    5. XM_054339342.1 → XP_054195317.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    6. XM_054339337.1 → XP_054195312.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

    7. XM_054339343.1 → XP_054195318.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

    8. XM_054339345.1 → XP_054195320.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

    9. XM_054339339.1 → XP_054195314.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1

    10. XM_054339340.1 → XP_054195315.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1

    11. XM_054339344.1 → XP_054195319.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

    12. XM_054339333.1 → XP_054195308.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

    13. XM_054339338.1 → XP_054195313.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

      UniProtKB/TrEMBL
      A0A499FJN1

    14. XM_054339346.1 → XP_054195321.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8

    15. XM_054339347.1 → XP_054195322.1  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_024175.1: Suppressed sequence

      Description
      NR_024175.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BUB5.1 GenPept UniProtKB/Swiss-Prot:Q9BUB5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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