RAB37 RAB37, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB37provided by HGNC
Official Full Name: RAB37, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:30268
See related: Ensembl:ENSG00000172794 MIM:609956; AllianceGenome:HGNC:30268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]
Expression: Broad expression in spleen (RPKM 9.4), bone marrow (RPKM 7.1) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (74671131..74747335)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (75561860..75639214)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (72667270..72743474)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Title: Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Low RAB37 expression is associated with lung cancer.
Title: Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
This study shows that RAB37 hypermethylation is involved in NPC metastasis and chemoresistance, and that our prognostic model can identify patients who are at a high risk of distant metastasis and might benefit from for docetaxel IC.
Title: RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Rab37-mediated SFRP1 secretion suppresses cancer stemness.
Title: Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
Findings indicate that patients with low vesicle associated membrane protein 8 (VAMP8)/low rab GTP-binding protein RAB37 (RAB37) expression profile showed significantly high risk of death even after adjusting for tumor metastasis parameter.
Title: VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
results demonstrate a role of RAB37 in autophagosome formation through a molecular connection of RAB37, ATG5-12, ATG16L1 up to LC3B, suggesting an organiser role of RAB37 during autophagosomal membrane biogenesis.
Title: RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly.
Our findings suggest that Rab37-mediated TSP1 secretion in cancer cells suppresses metastasis and angiogenesis via a cross-talk with endothelial cells and reveal a novel component of the vesicular exocytic machinery in tumor microenvironment and tumor progression
Title: Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Results identify Rab37 as an additional component of the machinery governing exocytosis of beta-cells and suggest that impaired expression of this GTPase may contribute to defective insulin release in pre-diabetic and diabetic conditions.
Title: The GTPase Rab37 Participates in the Control of Insulin Exocytosis.
RAB37 regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 migration axis in vitro and in vivo and to suppress tumor metastasis.
Title: Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
Rab37 mRNA was specifically expressed in some ESCC cell lines but its genetic polymorphisms were not associated with esophageal squamous cell carcinoma.
Title: An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RAB37, member RAS oncogene family by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92683 (e-PCR)
- UniSTS:88578

D17S625 (e-PCR)
- UniSTS:44076

G10539 (e-PCR)
- UniSTS:6231

RH122307 (e-PCR)
- UniSTS:137831

D17S1301 (e-PCR), detects polymorphism
- UniSTS:1213

D17S709 (e-PCR)
- UniSTS:28110

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras-related protein Rab-37

Names: RAB37, member of RAS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006638.3 → NP_001006639.1 ras-related protein Rab-37 isoform 2

See identical proteins and their annotated locations for NP_001006639.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (2) has a distinct and longer N-terminus, compared to isoform 3.

Source sequence(s)

AC016888, AK098068, BC016615

Consensus CDS

CCDS32722.1

UniProtKB/Swiss-Prot

A8MXF5, A8MYT0, Q8IWA7, Q96AX2

UniProtKB/TrEMBL

A8MTC6

Related

ENSP00000376389.5, ENST00000392613.10

Conserved Domains (1) summary

cd04112
Location:31 → 220

Rab26; Rab GTPase family 26 (Rab26)
NM_001163989.3 → NP_001157461.2 ras-related protein Rab-37 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents use of an alternate promoter, 5' UTR, and alternate start codon, and includes an alternate coding exon, compared to variant 3. The resulting isoform (4) has a distinct and longer N-terminus, compared to isoform 3.

Source sequence(s)

AC016888

Consensus CDS

CCDS54161.1

UniProtKB/TrEMBL

A0A9H3ZVF6

Related

ENSP00000376390.5, ENST00000392614.8
NM_001163990.2 → NP_001157462.1 ras-related protein Rab-37 isoform 5

See identical proteins and their annotated locations for NP_001157462.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents use of an alternate promoter, 5' UTR and alternate start codon, compared to variant 3. The resulting isoform (5) has a distinct and shorter N-terminus, compared to isoform 3.

Source sequence(s)

AC016888, AK296172, BC016615

Consensus CDS

CCDS54162.1

UniProtKB/TrEMBL

A8MTC6

Related

ENSP00000376388.3, ENST00000392612.7

Conserved Domains (1) summary

cd04112
Location:30 → 183

Rab26; Rab GTPase family 26 (Rab26)
NM_001330471.2 → NP_001317400.1 ras-related protein Rab-37 isoform 6

Status: VALIDATED

Source sequence(s)

AC016888, AK057069, AK098068, AK296062, BC016615

Consensus CDS

CCDS82198.1

UniProtKB/TrEMBL

A8MTC6, B7Z3L0

Related

ENSP00000432086.1, ENST00000528438.5
NM_175738.5 → NP_783865.1 ras-related protein Rab-37 isoform 3

See identical proteins and their annotated locations for NP_783865.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.

Source sequence(s)

AC016888, AK290202, BC016615, DA164538

Consensus CDS

CCDS11703.1

UniProtKB/TrEMBL

A8MSP2

Related

ENSP00000383934.4, ENST00000402449.8

Conserved Domains (2) summary

smart00175
Location:24 → 185

RAB; Rab subfamily of small GTPases

cd04112
Location:23 → 213

Rab26; Rab GTPase family 26 (Rab26)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

74671131..74747335

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

75561860..75639214

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001006637.1: Suppressed sequence

Description

NM_001006637.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.