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    TMEM233 transmembrane protein 233 [ Homo sapiens (human) ]

    Gene ID: 387890, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM233provided by HGNC
    Official Full Name
    transmembrane protein 233provided by HGNC
    Primary source
    HGNC:HGNC:37219
    See related
    Ensembl:ENSG00000224982 MIM:618296; AllianceGenome:HGNC:37219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSPB2; IFITMD2
    Summary
    Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thyroid (RPKM 3.9), brain (RPKM 1.9) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM233 in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119593774..119654295)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119581202..119641838)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120031579..120080880)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr12:119745461-119745962 Neighboring gene long intergenic non-protein coding RNA 934 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:119807339-119808538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7114 Neighboring gene coiled-coil domain containing 60 Neighboring gene uncharacterized LOC105370027 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119828163-119828664 Neighboring gene NANOG hESC enhancer GRCh37_chr12:119861020-119861540 Neighboring gene MPRA-validated peak2000 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:119924434-119924986 Neighboring gene MPRA-validated peak2001 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120031567-120032140 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120106633-120107268 Neighboring gene uncharacterized LOC124903033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115207-120115708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115709-120116208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120125555-120126425 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene microRNA 1178 Neighboring gene citron rho-interacting serine/threonine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 233
    Names
    dispanin subfamily B member 2
    interferon induced transmembrane protein domain containing 2
    interferon-induced transmembrane domain-containing protein D2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136534.3 → NP_001130006.1  transmembrane protein 233

      See identical proteins and their annotated locations for NP_001130006.1

      Status: VALIDATED

      Source sequence(s)
      AA476740, AC002563, DC315309, GD264605
      Consensus CDS
      CCDS44995.1
      UniProtKB/Swiss-Prot
      B4DJY2
      Related
      ENSP00000403130.1, ENST00000426426.3
      Conserved Domains (1) summary
      pfam04505
      Location:33 → 88
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      119593774..119654295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538329.3 → XP_011536631.1  transmembrane protein 233 isoform X2

      See identical proteins and their annotated locations for XP_011536631.1

      Conserved Domains (1) summary
      pfam04505
      Location:33 → 88
      CD225; Interferon-induced transmembrane protein

    2. XM_011538330.3 → XP_011536632.1  transmembrane protein 233 isoform X3

      Conserved Domains (1) summary
      pfam04505
      Location:29 → 88
      CD225; Interferon-induced transmembrane protein

    3. XM_005253881.4 → XP_005253938.1  transmembrane protein 233 isoform X2

      See identical proteins and their annotated locations for XP_005253938.1

      Conserved Domains (1) summary
      pfam04505
      Location:33 → 88
      CD225; Interferon-induced transmembrane protein

    4. XM_011538328.4 → XP_011536630.1  transmembrane protein 233 isoform X2

      See identical proteins and their annotated locations for XP_011536630.1

      Conserved Domains (1) summary
      pfam04505
      Location:33 → 88
      CD225; Interferon-induced transmembrane protein

    5. XM_011538331.4 → XP_011536633.1  transmembrane protein 233 isoform X4

      Conserved Domains (1) summary
      pfam04505
      Location:29 → 88
      CD225; Interferon-induced transmembrane protein

    6. XM_005253880.4 → XP_005253937.1  transmembrane protein 233 isoform X1

      Conserved Domains (1) summary
      pfam04505
      Location:29 → 88
      CD225; Interferon-induced transmembrane protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      119581202..119641838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372039.1 → XP_054228014.1  transmembrane protein 233 isoform X3

    2. XM_054372038.1 → XP_054228013.1  transmembrane protein 233 isoform X2

    3. XM_054372036.1 → XP_054228011.1  transmembrane protein 233 isoform X2

    4. XM_054372037.1 → XP_054228012.1  transmembrane protein 233 isoform X2

    5. XM_054372040.1 → XP_054228015.1  transmembrane protein 233 isoform X4

    6. XM_054372035.1 → XP_054228010.1  transmembrane protein 233 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4DJY2.1 GenPept UniProtKB/Swiss-Prot:B4DJY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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