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    FAM149A family with sequence similarity 149 member A [ Homo sapiens (human) ]

    Gene ID: 25854, updated on 17-Sep-2024

    Summary

    Official Symbol
    FAM149Aprovided by HGNC
    Official Full Name
    family with sequence similarity 149 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:24527
    See related
    Ensembl:ENSG00000109794 AllianceGenome:HGNC:24527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MST119; MSTP119
    Expression
    Broad expression in kidney (RPKM 4.2), liver (RPKM 2.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FAM149A in Genome Data Viewer
    Location:
    4q35.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (186104704..186175337)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (189445101..189515714)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (187025858..187096491)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:186948264-186949463 Neighboring gene RNA, U4 small nuclear 64, pseudogene Neighboring gene toll like receptor 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15857 Neighboring gene uncharacterized LOC124900171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22266 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187064906-187065406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187065407-187065907 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:187069874-187071073 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:187071092-187071287 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:187079637-187080136 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:187091342-187092541 Neighboring gene ribosomal protein SA pseudogene 70 Neighboring gene LTO1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22267 Neighboring gene uncharacterized LOC651430 Neighboring gene cytochrome P450 family 4 subfamily V member 2 Neighboring gene kallikrein B1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of family with sequence similarity 149, member A (FAM149A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp564J102

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006655.3NP_001006656.1  protein FAM149A isoform 1

      See identical proteins and their annotated locations for NP_001006656.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC110771, AF173894, BC142992, BU609191, CD516421
      Consensus CDS
      CCDS34117.1
      UniProtKB/TrEMBL
      B9EGU9
      Related
      ENSP00000424380.1, ENST00000514153.5
      Conserved Domains (1) summary
      pfam12516
      Location:266
      DUF3719; Protein of unknown function (DUF3719)
    2. NM_001350178.1NP_001337107.1  protein FAM149A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
      Source sequence(s)
      AK309233, BC142992, BC144411, BU609191, CD516421
      UniProtKB/TrEMBL
      B7ZMB5
      Conserved Domains (1) summary
      pfam12516
      Location:266
      DUF3719; Protein of unknown function (DUF3719)
    3. NM_001350179.1NP_001337108.1  protein FAM149A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
      Source sequence(s)
      AK309233, BC142992, BC144411, BU609191, CD516421, DA159632
      UniProtKB/TrEMBL
      B7ZMB5
      Conserved Domains (1) summary
      pfam12516
      Location:266
      DUF3719; Protein of unknown function (DUF3719)
    4. NM_001367768.3NP_001354697.1  protein FAM149A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, uses multiple alternate splice sites, and extends the 5' coding region compared to variant 1. It encodes isoform 3 which is longer than isoform 1.
      Source sequence(s)
      AC104070, AC110771
      Consensus CDS
      CCDS93680.1
      UniProtKB/Swiss-Prot
      A5PLN7, B5MDB8, Q2TAN6, Q7Z2S5, Q9Y4T9
      UniProtKB/TrEMBL
      A0A0A0MRZ3
      Related
      ENSP00000374005.7, ENST00000389354.7
    5. NM_001395294.1NP_001382223.1  protein FAM149A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104070, AC110771
      UniProtKB/Swiss-Prot
      A5PLN7, B5MDB8, Q2TAN6, Q7Z2S5, Q9Y4T9
      Related
      ENSP00000516649.1, ENST00000706927.1
      Conserved Domains (1) summary
      PHA03247
      Location:18144
      PHA03247; large tegument protein UL36; Provisional
    6. NM_015398.4NP_056213.1  protein FAM149A isoform 1

      See identical proteins and their annotated locations for NP_056213.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer isoform (1). Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC110771, AF173894, BC110816, BU609191
      Consensus CDS
      CCDS34117.1
      UniProtKB/TrEMBL
      B9EGU9
      Related
      ENSP00000227065.4, ENST00000227065.8
      Conserved Domains (1) summary
      pfam12516
      Location:266
      DUF3719; Protein of unknown function (DUF3719)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      186104704..186175337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      189445101..189515714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)