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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_042857.2 RefSeqGene
- Range
-
5002..59168
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001282424.3 → NP_001269353.2 alpha-2-macroglobulin-like protein 1 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) represents use of an alternate promoter, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate AUG, and the resulting isoform (2) has a distinct and shorter N-terminus compared to isoform 1.
- Source sequence(s)
-
AC006513, AC006581
- Consensus CDS
-
CCDS73439.1
- UniProtKB/TrEMBL
-
H0YGG5
- Related
- ENSP00000438292.1, ENST00000539547.5
- Conserved Domains (4) summary
-
- cd02897
Location:465 → 760
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:245 → 335
- A2M; Alpha-2-macroglobulin family
- pfam07677
Location:871 → 958
- A2M_recep; A-macroglobulin receptor
- pfam07703
Location:1 → 110
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
-
NM_144670.6 → NP_653271.3 alpha-2-macroglobulin-like protein 1 isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AC006513, AC006581
- Consensus CDS
-
CCDS8596.2
- UniProtKB/Swiss-Prot
- A8K2U0, B5MDD1, B7Z7V4, D3DUV3, F5H2Z2, Q2M224, Q6ZW52, Q6ZW53, Q8N1M4, Q96LQ8
- UniProtKB/TrEMBL
-
B3KVV6
- Related
- ENSP00000299698.7, ENST00000299698.12
- Conserved Domains (5) summary
-
- cd02897
Location:956 → 1251
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:736 → 826
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:122 → 211
- A2M_N; MG2 domain
- pfam07677
Location:1362 → 1449
- A2M_recep; A-macroglobulin receptor
- pfam07703
Location:459 → 601
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000012.12 Reference GRCh38.p14 Primary Assembly
- Range
-
8822621..8887459
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_011520566.3 → XP_011518868.1 alpha-2-macroglobulin-like protein 1 isoform X1
- UniProtKB/TrEMBL
-
B3KVV6
- Conserved Domains (7) summary
-
- COG2373
Location:123 → 1055
- YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
- cd02897
Location:969 → 1264
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:749 → 839
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:122 → 211
- A2M_N; MG2 domain
- pfam07677
Location:1375 → 1462
- A2M_recep; A-macroglobulin receptor
- pfam07678
Location:1021 → 1266
- A2M_comp; A-macroglobulin complement component
- pfam07703
Location:455 → 613
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
-
XM_047428387.1 → XP_047284343.1 alpha-2-macroglobulin-like protein 1 isoform X4
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_011520567.3 → XP_011518869.1 alpha-2-macroglobulin-like protein 1 isoform X1
- UniProtKB/TrEMBL
-
B3KVV6
- Conserved Domains (7) summary
-
- COG2373
Location:123 → 1055
- YfaS; Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]
- cd02897
Location:969 → 1264
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:749 → 839
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:122 → 211
- A2M_N; MG2 domain
- pfam07677
Location:1375 → 1462
- A2M_recep; A-macroglobulin receptor
- pfam07678
Location:1021 → 1266
- A2M_comp; A-macroglobulin complement component
- pfam07703
Location:455 → 613
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
-
XM_017018869.2 → XP_016874358.1 alpha-2-macroglobulin-like protein 1 isoform X2
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_017018870.2 → XP_016874359.1 alpha-2-macroglobulin-like protein 1 isoform X3
- UniProtKB/Swiss-Prot
- A8K2U0, B5MDD1, B7Z7V4, D3DUV3, F5H2Z2, Q2M224, Q6ZW52, Q6ZW53, Q8N1M4, Q96LQ8
- UniProtKB/TrEMBL
-
B3KVV6
- Conserved Domains (5) summary
-
- cd02897
Location:956 → 1251
- A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
- pfam00207
Location:736 → 826
- A2M; Alpha-2-macroglobulin family
- pfam01835
Location:122 → 211
- A2M_N; MG2 domain
- pfam07677
Location:1362 → 1449
- A2M_recep; A-macroglobulin receptor
- pfam07703
Location:459 → 601
- A2M_N_2; Alpha-2-macroglobulin family N-terminal region
RNA
-
XR_931275.2 RNA Sequence
-
XR_001748594.2 RNA Sequence
Alternate T2T-CHM13v2.0
Genomic
-
NC_060936.1 Alternate T2T-CHM13v2.0
- Range
-
8805910..8869474
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
XM_054371194.1 → XP_054227169.1 alpha-2-macroglobulin-like protein 1 isoform X1
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_054371198.1 → XP_054227173.1 alpha-2-macroglobulin-like protein 1 isoform X4
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_054371195.1 → XP_054227170.1 alpha-2-macroglobulin-like protein 1 isoform X1
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_054371196.1 → XP_054227171.1 alpha-2-macroglobulin-like protein 1 isoform X2
- UniProtKB/TrEMBL
-
B3KVV6
-
XM_054371197.1 → XP_054227172.1 alpha-2-macroglobulin-like protein 1 isoform X3
- UniProtKB/TrEMBL
-
B3KVV6
RNA
-
XR_008488540.1 RNA Sequence
-
XR_008488539.1 RNA Sequence