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    Asb8 ankyrin repeat and SOCS box-containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 78541, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Asb8provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 8provided by MGI
    Primary source
    MGI:MGI:1925791
    See related
    Ensembl:ENSMUSG00000048175 AllianceGenome:MGI:1925791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930539L19Rik; C430011H06Rik
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human ASB8 (ankyrin repeat and SOCS box containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 37.0), heart adult (RPKM 27.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb8 in Genome Data Viewer
    Location:
    15 F1; 15 54.13 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98032518..98063476, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98134637..98165596, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SUMO1/sentrin specific peptidase 1 Neighboring gene predicted gene, 25668 Neighboring gene STARR-seq mESC enhancer starr_39649 Neighboring gene STARR-positive B cell enhancer ABC_E10879 Neighboring gene STARR-positive B cell enhancer ABC_E5514 Neighboring gene STARR-seq mESC enhancer starr_39650 Neighboring gene phosphofructokinase, muscle Neighboring gene STARR-seq mESC enhancer starr_39651 Neighboring gene STARR-seq mESC enhancer starr_39652 Neighboring gene STARR-seq mESC enhancer starr_39654 Neighboring gene STARR-positive B cell enhancer ABC_E5515 Neighboring gene coiled-coil domain containing 184 Neighboring gene predicted gene, 33909 Neighboring gene olfactory receptor family 10 subfamily AD member 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. Liu Y, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559969
    2. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 8
    Names
    ASB-8
    ankyrin repeat and SOCS box-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170710.1 → NP_001164181.1  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_001164181.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168, AK087299, BY240190
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000121383.2, ENSMUST00000123626.8
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    2. NM_001170711.1 → NP_001164182.1  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_001164182.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000115813.2, ENSMUST00000143400.8
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    3. NM_030121.4 → NP_084397.3  ankyrin repeat and SOCS box protein 8

      See identical proteins and their annotated locations for NP_084397.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK016001, AK030168, BY240190
      Consensus CDS
      CCDS27787.1
      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000057864.6, ENSMUST00000059112.12
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98032518..98063476 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521542.5 → XP_006521605.1  ankyrin repeat and SOCS box protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006521605.1

      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    2. XM_030248819.2 → XP_030104679.1  ankyrin repeat and SOCS box protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    3. XM_011245775.4 → XP_011244077.1  ankyrin repeat and SOCS box protein 8 isoform X1

      See identical proteins and their annotated locations for XP_011244077.1

      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Related
      ENSMUSP00000119481.2, ENSMUST00000123922.2
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]

    4. XM_030248820.2 → XP_030104680.1  ankyrin repeat and SOCS box protein 8 isoform X1

      UniProtKB/Swiss-Prot
      Q8R178, Q91ZT9
      UniProtKB/TrEMBL
      A0A0R4J1W1, Q8CDF0, Q9D4Y2
      Conserved Domains (3) summary
      PHA02876
      Location:26 → 215
      PHA02876; ankyrin repeat protein; Provisional
      cd03727
      Location:245 → 287
      SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
      sd00045
      Location:56 → 83
      ANK; ANK repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZT9.1 GenPept UniProtKB/Swiss-Prot:Q91ZT9

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