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    Galnt6 polypeptide N-acetylgalactosaminyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 207839, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Galnt6provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 6provided by MGI
    Primary source
    MGI:MGI:1891640
    See related
    Ensembl:ENSMUSG00000037280 AllianceGenome:MGI:1891640
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GalNAc-T6; 4632410F13
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus. Is expressed in exocrine system; paravertebral ganglion; and skeleton. Orthologous to human GALNT6 (polypeptide N-acetylgalactosaminyltransferase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in large intestine adult (RPKM 18.2), small intestine adult (RPKM 15.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt6 in Genome Data Viewer
    Location:
    15 F1; 15 56.39 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100587796..100627257, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100689915..100729376, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene bridging integrator 2 Neighboring gene microRNA 6961 Neighboring gene STARR-positive B cell enhancer ABC_E311 Neighboring gene chymotrypsin-like elastase family, member 1 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E10882 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5518 Neighboring gene STARR-positive B cell enhancer ABC_E2451 Neighboring gene predicted gene, 52175 Neighboring gene solute carrier family 4 (anion exchanger), member 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. Bennett EP, et al. J Biol Chem, 1999 Sep 3. PMID 10464263
    2. Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans. Yoshida CA, et al. J Biol Chem, 2014 Sep 19. PMID 25107907, Free PMC Article
    3. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    4. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article
    5. Galnt1 is required for normal heart valve development and cardiac function. Tian E, et al. PLoS One, 2015. PMID 25615642, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This paper describes the identification and cloning of the orthologous human enzyme of mouse UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6.
      Title: Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 6
    Names
    N-acetylgalactosaminyltransferase T-6
    Protein-UDP acetylgalactosaminyltransferase 6
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 6
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6
    polypeptide GalNAc transferase 6
    pp-GaNTase 6
    NP_001155239.1
    NP_001155240.1
    NP_766039.2
    XP_030104297.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161767.1 → NP_001155239.1  polypeptide N-acetylgalactosaminyltransferase 6

      See identical proteins and their annotated locations for NP_001155239.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC123724, AK159721, BQ175003, BY196827
      Consensus CDS
      CCDS27843.1
      UniProtKB/Swiss-Prot
      Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
      Related
      ENSMUSP00000056705.6, ENSMUST00000052069.12
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001161768.1 → NP_001155240.1  polypeptide N-acetylgalactosaminyltransferase 6

      See identical proteins and their annotated locations for NP_001155240.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC123724, AK049222, BQ175003
      Consensus CDS
      CCDS27843.1
      UniProtKB/Swiss-Prot
      Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
      Related
      ENSMUSP00000124793.2, ENSMUST00000161514.2
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_172451.3 → NP_766039.2  polypeptide N-acetylgalactosaminyltransferase 6

      See identical proteins and their annotated locations for NP_766039.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC123724, AK028506, AK159721, BQ175003
      Consensus CDS
      CCDS27843.1
      UniProtKB/Swiss-Prot
      Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
      Related
      ENSMUSP00000123848.2, ENSMUST00000159715.8
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100587796..100627257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248437.2 → XP_030104297.1  polypeptide N-acetylgalactosaminyltransferase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q0VE84, Q3TWF0, Q8C7U7, Q8CED2, Q9QZ16
      Conserved Domains (2) summary
      cd02510
      Location:180 → 485
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:497 → 619
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C7U7.1 GenPept UniProtKB/Swiss-Prot:Q8C7U7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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