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    Tars3 threonyl-tRNA synthetase 3 [ Mus musculus (house mouse) ]

    Gene ID: 272396, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tars3provided by MGI
    Official Full Name
    threonyl-tRNA synthetase 3provided by MGI
    Primary source
    MGI:MGI:2444486
    See related
    Ensembl:ENSMUSG00000030515 AllianceGenome:MGI:2444486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tarsl2; A530046H20Rik
    Summary
    Enables threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Orthologous to human TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 7.7), liver E14.5 (RPKM 6.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tars3 in Genome Data Viewer
    Location:
    7 C; 7 35.23 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (65294610..65341841)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (65644898..65692093)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene tight junction protein 1 Neighboring gene STARR-seq mESC enhancer starr_19058 Neighboring gene STARR-seq mESC enhancer starr_19059 Neighboring gene STARR-seq mESC enhancer starr_19061 Neighboring gene cDNA sequence BC046251 Neighboring gene STARR-positive B cell enhancer ABC_E1341 Neighboring gene predicted gene, 51484 Neighboring gene predicted gene, 33234 Neighboring gene TM2 domain containing 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development. Zeng QY, et al. J Biol Chem, 2023 May. PMID 37059185, Free PMC Article
    2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex. Zhou XL, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287872, Free PMC Article
    3. A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities. Chen Y, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29579307, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.
      Title: Loss of threonyl-tRNA synthetase-like protein Tarsl2 has little impact on protein synthesis but affects mouse development.
    2. Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
      Title: Newly acquired N-terminal extension targets threonyl-tRNA synthetase-like protein into the multiple tRNA synthetase complex.
    3. Our results provided the first analysis of the aminoacylation and editing activities of ThrRS-L, and improved our understanding of Tarsl2.
      Title: A threonyl-tRNA synthetase-like protein has tRNA aminoacylation and editing activities.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31414

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables threonine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables threonine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in threonyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in threonyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    threonine--tRNA ligase 2, cytoplasmic
    Names
    probable threonine--tRNA ligase 2, cytoplasmic
    probable threonyl-tRNA synthetase 2, cytoplasmic
    thrRS
    threonyl-tRNA synthetase protein 3
    threonyl-tRNA synthetase-like 2
    threonyl-tRNA synthetase-like protein 2
    NP_758514.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172310.2 → NP_758514.2  threonine--tRNA ligase 2, cytoplasmic

      See identical proteins and their annotated locations for NP_758514.2

      Status: VALIDATED

      Source sequence(s)
      AK040927, AV355827, BB642214
      Consensus CDS
      CCDS21339.1
      UniProtKB/Swiss-Prot
      Q8BLY2, Q8CHT2
      Related
      ENSMUSP00000032728.9, ENSMUST00000032728.9
      Conserved Domains (6) summary
      cd01667
      Location:150 → 211
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
      PLN02908
      Location:108 → 783
      PLN02908; threonyl-tRNA synthetase
      smart00863
      Location:317 → 364
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      cd00771
      Location:388 → 685
      ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
      cd00860
      Location:685 → 776
      ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
      cl23720
      Location:14 → 107
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      65294610..65341841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004934116.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLY2.1 GenPept UniProtKB/Swiss-Prot:Q8BLY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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